Flexible and oriented composite electrospun fiber membrane based on poly(L-lactic acid) for self-powered sensing DOI

Yongxian Wen,

Menghan Xu,

Yang Hu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161795 - 161795

Published: March 1, 2025

Language: Английский

Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications DOI
Yuan Xue, Jiacheng Shi, Yong Kang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

Citations

76

A 3D printable gelatin methacryloyl/chitosan hydrogel assembled with conductive PEDOT for neural tissue engineering DOI
Ying Han, Mouyuan Sun, Xingchen Lu

et al.

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 273, P. 111241 - 111241

Published: Jan. 24, 2024

Language: Английский

Citations

36

Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review DOI Creative Commons
Lada E. Shlapakova,

Maria A. Surmeneva,

Andréi L. Kholkin

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100950 - 100950

Published: Jan. 11, 2024

Nerve injuries pose a drastic threat to nerve mobility and sensitivity lead permanent dysfunction due low regenerative capacity of mature neurons. The electrical stimuli that can be provided by electroactive materials are some the most effective tools for formation soft tissues, including nerves. Electric output provide distinctly favorable bioelectrical microenvironment, which is especially relevant nervous system. Piezoelectric biomaterials have attracted attention in field neural tissue engineering owing their biocompatibility ability generate piezoelectric surface charges. In this review, an outlook recent achievements described with emphasis on polymers engineering. First, general recommendations design optimal scaffold discussed. Then, specific mechanisms determining regeneration via stimulation considered. Activation responses natural body movements, ultrasound, magnetic fillers also examined. use magnetoelectric combination alternating fields thought promising controllable reproducible cyclic deformations deep permeation without heating.

Language: Английский

Citations

28

Sea Cucumber-Inspired Microneedle Nerve Guidance Conduit for Synergistically Inhibiting Muscle Atrophy and Promoting Nerve Regeneration DOI

Cewen Hu,

Bin Liu,

Xinyue Huang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14427 - 14440

Published: May 22, 2024

Muscle atrophy resulting from peripheral nerve injury (PNI) poses a threat to patient's mobility and sensitivity. However, an effective method inhibit muscle following PNI remains elusive. Drawing inspiration the sea cucumber, we have integrated microneedles (MNs) microchannel technology into guidance conduits (NGCs) develop bionic microneedle NGCs (MNGCs) that emulate structure piezoelectric function of cucumbers. Morphologically, MNGCs feature outer surface with outward-pointing needle tips capable applying electrical stimulation denervated muscles. Simultaneously, interior contains microchannels designed guide migration Schwann cells (SCs). Physiologically, incorporation conductive reduced graphene oxide zinc nanoparticles polycaprolactone scaffold enhances conductivity properties, facilitating SCs' migration, myelin regeneration, axon growth, restoration neuromuscular function. These combined effects ultimately lead inhibition Consequently, concept synergistic effect inhibiting promoting regeneration has capacity transform traditional approach repair find broad applications in repair.

Language: Английский

Citations

22

From emerging modalities to advanced applications of hydrogel piezoelectrics based on chitosan, gelatin and related biological macromolecules: A review DOI
Peng Fan,

Hengwei Fan,

Shige Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129691 - 129691

Published: Jan. 24, 2024

Language: Английский

Citations

20

Flexible Organic Photovoltaic‐Powered Hydrogel Bioelectronic Dressing With Biomimetic Electrical Stimulation for Healing Infected Diabetic Wounds DOI Creative Commons
Yiwei Hu, Yuheng Wang, Fang Yang

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(10)

Published: Dec. 25, 2023

Abstract Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption limited by the requirement of additional extracorporeal devices to power ES‐based wound dressings. In this study, novel sandwich‐structured photovoltaic microcurrent hydrogel dressing (PMH dressing) designed treating diabetic This innovative comprises flexible organic (OPV) cells, micro–electro–mechanical systems (MEMS) electrode, and multifunctional serving an electrode–tissue interface. The PMH engineered administer ES, mimicking physiological injury current occurring naturally in wounds when exposed light; thus, facilitating healing. vitro experiments are performed validate dressing's exceptional biocompatibility robust antibacterial properties. vivo proteomic analysis reveal that significantly accelerates healing infected enhancing extracellular matrix regeneration, eliminating bacteria, regulating inflammatory responses, modulating vascular functions. Therefore, potent, versatile, effective care, paving way advancements wireless ES

Language: Английский

Citations

27

Filler‐Enhanced Piezoelectricity of Poly‐L‐Lactide and Its Use as a Functional Ultrasound‐Activated Biomaterial DOI Creative Commons
Marija Vukomanović,

Lea Gazvoda,

Mario Kurtjak

et al.

Small, Journal Year: 2023, Volume and Issue: 19(35)

Published: April 26, 2023

Poly-L-lactide (PLLA) offers a unique possibility for processing into biocompatible, biodegradable, and implantable piezoelectric structures. With such properties, PLLA has potential to be used as an advanced tool mimicking biophysical processes that naturally occur during the self-repair of wounds damaged tissues, including electrostimulated regeneration. The piezoelectricity strongly depends on controlling its crystallinity molecular orientation. Here, it is shown modifying with small amount (1 wt%) crystalline filler particles high aspect ratio, which act nucleating agents drawing-induced crystallization, promotes formation highly oriented This increases their piezoelectricity, filler-modified films provide 20-fold larger voltage output than nonmodified ultrasound (US)-assisted activation. 99% content, ability produce reactive oxygen species (ROS) increase local temperature interactions US very low. US-assisted piezostimulation adherent cells directly attach surface (such skin keratinocytes), stimulate cytoskeleton formation, result elongate orient themselves in specific direction align film drawing dipole

Language: Английский

Citations

23

Degradable piezoelectric biomaterials for medical applications DOI Creative Commons
Yuan Bai, Hongyu Meng, Zhou Li

et al.

MedMat., Journal Year: 2024, Volume and Issue: 1(1), P. 40 - 49

Published: May 13, 2024

The energy harvesting technology based on piezoelectricity promises to achieve a self-powered mode for portable medical electronic devices. Piezoelectric materials, as crucial components in electromechanical applications, have extensively been utilized Especially, degradable piezoelectric biomaterials received much attention the field due their excellent biocompatibility and biosafety. This mini-review mainly summarizes types structural characteristics of from small-molecule crystals polymers. Afterward, applications are briefly introduced, including harvester sensor, actuator transducer, tissue engineering scaffold. Finally, material perspective, some challenges currently faced by proposed.

Language: Английский

Citations

15

A review of recent advances of piezoelectric poly-L-lactic acid for biomedical applications DOI
Siwei Zhang, H. ZHANG, Jiangtao Sun

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133748 - 133748

Published: July 8, 2024

Language: Английский

Citations

14

Alginate-PVDF piezoelectric hydrogel containing calcium copper titanate- hydroxyapatite as a self-powered scaffold for bone tissue engineering and energy harvesting DOI
Yeganeh Khazani, Ezzat Rafiee, Ali Samadi

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 687, P. 133537 - 133537

Published: Feb. 23, 2024

Language: Английский

Citations

12