Nanozyme-Based Cancer Nanotheranostics: Emerging Applications and Challenges in Brain Cancer Therapeutics DOI Creative Commons
Alexandra A.P. Mansur, Herman S. Mansur

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4

Published: Jan. 31, 2025

Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.

Language: Английский

Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions DOI Creative Commons
Haijiao Dong, Wei Du, Jian Dong

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 12, 2022

As pioneering Fe

Language: Английский

Citations

257
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy DOI Creative Commons
Xiaodong Zhang, Xiaokai Chen,

Yanli Zhao

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

Citations

186
Recent progress of metal‐based nanomaterials with anti‐tumor biological effects for enhanced cancer therapy DOI Creative Commons

Huali Lei,

Zifan Pei, Chenyu Jiang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(5)

Published: June 30, 2023

Abstract Metal‐based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely effects. In particular, the abilities of Ca 2+ modulate T cell receptors activation, K + regulate stem differentiation, Mn activate STING pathway, Fe 2+/3+ induce ferroptosis enhance catalytic therapy, make metal ions metal‐based play crucial roles in cancer treatments. Therefore, superior advantages characteristics microenvironment, we will summarize recent progress anti‐tumor effects nanomaterials. Based on different this review mainly focuses following five aspects: (1) metal‐enhanced radiotherapy sensitization, (2) (3) ferroptosis, (4) pyroptosis, (5) immunotherapy. At same time, shortcomings therapy are also discussed, future research directions been prospected. The highlights promising biosafety, potent efficacy for in‐depth various mechanism studies provide novel ideas application

Language: Английский

Citations

94
Reaction Mechanisms and Kinetics of Nanozymes: Insights from Theory and Computation DOI
Xiaomei Shen, Zhenzhen Wang,

Xuejiao J. Gao

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Jan. 15, 2023

Abstract “Nanozymes” usually refers to inorganic nanomaterials with enzyme‐like catalytic activities. The research into nanozymes is one of the hot topics on horizon interdisciplinary science involving materials, chemistry, and biology. Although great progress has been made in design, synthesis, characterization, application nanozymes, study underlying microscopic mechanisms kinetics still not straightforward. Density functional theory (DFT) calculations compute potential energy surfaces along reaction coordinates for chemical reactions, which can give atomistic‐level insights micro‐mechanisms nanozymes. Therefore, DFT have playing an increasingly important role exploring past years. either predict details processes complement experiments or further develop theoretical models depict physicochemical rules. In this review, corresponding summarized. Particularly, review focuses computational studies that closely interplay experiments. relevant experimental results without will be also briefly discussed offer a historic overview how computations promote understanding

Language: Английский

Citations

93
Piezoelectric enhanced peroxidase-like activity of metal-free sulfur doped graphdiyne nanosheets for efficient water pollutant degradation and bacterial disinfection DOI
Jiancheng Zhang, Qiang Bai, Xuelong Bi

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 43, P. 101429 - 101429

Published: Feb. 12, 2022

Language: Английский

Citations

92
Enzyme mimic nanomaterials as nanozymes with catalytic attributes DOI Creative Commons
Muhammad Bilal,

Nida Khaliq,

Mubeen Ashraf

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 221, P. 112950 - 112950

Published: Oct. 20, 2022

Nanozymes are super-efficient nanomaterials with enzyme-like characteristics, as the name suggests. In last decade, efforts have been made to develop "artificial enzymes," which alternatives natural enzymes. As nanoscience and nanotechnology advance, nanozymes, catalytic having properties, fascinated researchers' attention. unique physicochemical properties that mimic activity gained a special interest in industrial sectors. However, several constraints hampered their effective deployment processes, including denaturation, time-consuming manufacturing, overall high cost-ratio, reutilization challenges. After brief overview of nanozyme research, an analysis similarities differences between nanozymes synthetic enzymes is presented. Because distinct stand out this comparison. exhibited variety applications leveraging physiochemical nanomaterials, ranging from vitro detection enzyme substitution biological systems. addition, introduced new field called nanozymology, blends enzymology.

Language: Английский

Citations

92
Biomedicine meets nanozyme catalytic chemistry DOI

Changyu Cao,

Nan Yang,

Xiaorui Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

Citations

87
Exploring the Specificity of Nanozymes DOI
Huizhen Fan, Ruofei Zhang, Kelong Fan

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 2533 - 2540

Published: Jan. 12, 2024

Nanozymes, nanomaterials exhibiting enzyme-like activities, have emerged as a prominent interdisciplinary field over the past decade. To date, 1200 different been identified nanozymes, covering four catalytic categories: oxidoreductases, hydrolases, isomerases, and lyases. Catalytic activity specificity are two pivotal benchmarks for evaluating enzymatic performance. Despite substantial progress being made in quantifying optimizing of there is still lack in-depth research on preventing formation consensual knowledge impeding more refined systematic classification nanozymes. Recently, debates regarding whether nanozymes could possess similar to that enzymes. This Perspective discusses by referring enzymes, highlights gap between concludes offering our perspective future

Language: Английский

Citations

84
Multifunctional MnCo@C yolk-shell nanozymes with smartphone platform for rapid colorimetric analysis of total antioxidant capacity and phenolic compounds DOI
Xu Zhu, Jing Tang,

Xilian Ouyang

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 216, P. 114652 - 114652

Published: Aug. 24, 2022

Language: Английский

Citations

71
Research Progress in Iron-Based Nanozymes: Catalytic Mechanisms, Classification, and Biomedical Applications DOI

Ruixue Fu,

Zijian Ma,

Hongbin Zhao

et al.

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(29), P. 10844 - 10858

Published: July 12, 2023

Natural enzymes are crucial in biological systems and widely used biology medicine, but their disadvantages, such as insufficient stability high-cost, have limited wide application. Since Fe3O4 nanoparticles were found to show peroxidase-like activity, researchers designed developed a growing number of nanozymes that mimic the activity natural enzymes. Nanozymes can compensate for defects higher with lower cost. Iron, nontoxic low-cost transition metal, has been synthesize variety iron-based unique structural physicochemical properties obtain different mimicking catalytic properties. In this perspective, mechanisms, modulation, recent research progress sensing, tumor therapy, antibacterial anti-inflammatory applications systematically presented. The challenges perspectives on development also analyzed discussed.

Language: Английский

Citations

66