CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations DOI Creative Commons
Martı́n Cammarota, Janine I. Rossato, María Carolina González

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a object, consolidated ORM can be destabilized linked that generated by object through reconsolidation. The CA1 region dorsal hippocampus contributes destabilization reconsolidation mechanisms involving theta/gamma cross-frequency coupling (hPAC) synaptic plasticity modulation. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is vital for hippocampus-dependent processing has been associated with theta activity-dependent CA1. However, specific role hippocampal CaMKII lasting storage remains unclear, its potential impact on memory-related oscillatory activity not previously investigated. To explore these questions, we employed combination behavioral, electrophysiological, pharmacological approaches at various stages processing, found necessary or but does regulate novelty-induced modulating hPAC.

Language: Английский

Alzheimer’s disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression DOI Creative Commons
S. Meftah, Jian Gan

Frontiers in Synaptic Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: March 9, 2023

The synapse has consistently been considered a vulnerable and critical target within Alzheimer’s disease, loss is, to date, one of the main biological correlates cognitive decline disease. This occurs prior neuronal with ample evidence that synaptic dysfunction precedes this, in support idea failure is crucial stage disease pathogenesis. two pathological hallmarks abnormal aggregates amyloid or tau proteins, have had demonstrable effects on physiology animal cellular models There also growing these proteins may synergistic effect neurophysiological dysfunction. Here, we review some findings alterations what know from models. First, briefly summarize human suggest synapses are altered, including how this relates network activity. Subsequently, considered, highlighting mouse pathology role play dysfunction, either isolation examining pathologies interact specifically focuses function observed models, typically measured using electrophysiology calcium imaging. Following loss, it would be impossible imagine not alter oscillatory activity brain. Therefore, discusses underpin aberrant patterns seen patients. Finally, an overview key directions considerations field covered. includes current therapeutics targeted at but methods modulate rescue patterns. Other important future avenues note include non-neuronal cell types such as astrocytes microglia, mechanisms independent will certainly continue for foreseeable future.

Language: Английский

Citations

73
Physical exercise for brain plasticity promotion an overview of the underlying oscillatory mechanism DOI Creative Commons
Xueyang Li,

Xuehong Qu,

Kaixuan Shi

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 8, 2024

The global recognition of the importance physical exercise (PE) for human health has resulted in increased research on its effects cortical activity. Neural oscillations, which are prominent features brain activity, serve as crucial indicators studying PE function. Existing studies support idea that modifies various types neural oscillations. While EEG-related literature science exists, a comprehensive review specifically healthy populations not yet been conducted. Given demonstrated influence plasticity, particularly oscillatory it is imperative to consolidate this phenomenon. Therefore, aims summarize numerous neuromodulatory mechanisms over past decade, covering (1) resistance and aerobic training via oscillations; (2) how mind-body affects activity cognitive functioning; (3) age-Related neurodegenerative disease rehabilitation oscillation mechanisms; (4) conclusion future direction. In conclusion, effect multifaceted process, seeks comprehensively examine existing studies' understanding regulates brain, providing more scientific theoretical foundation development personalized programs further research.

Language: Английский

Citations

6
Interictal epileptiform discharges affect memory in an Alzheimer’s disease mouse model DOI Creative Commons
Marisol Soula, Anna Maslarova, Ryan E. Harvey

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(34)

Published: Aug. 17, 2023

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but also present other neurological diseases, such as Alzheimer's disease (AD). Understanding the role IEDs have on hippocampal circuit is important for our understanding of cognitive deficits seen and AD. We characterize compare human from microwire recording with those AD transgenic mice implanted multilayer silicon probes. Both local field potential features firing patterns pyramidal cells interneurons were similar mouse human. found that emerged CA3-1 circuits, they recruited silenced interneurons, followed by post-IED suppression. suppressed incidence altered properties physiological sharp-wave ripples, their properties, interfered replay place sequences a maze. In addition, inversely correlated daily memory performance. Together, work implies may common epilepsy-independent phenomenon neurodegenerative diseases perturbs hippocampal-cortical communication interferes memory.

Language: Английский

Citations

14
Impairment of entorhinal cortex network activity in Alzheimer’s disease DOI Creative Commons

Farnaz Karimani,

Afsaneh Asgari Taei,

Mohammad-Reza Abolghasemi-Dehaghani

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: May 31, 2024

The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of Alzheimer’s disease (AD), with some disease’s pathological processes originating from this area, making it one most crucial regions AD. Recent research highlights disruptions brain’s network activity, characterized by heightened excitability and irregular oscillations, may contribute to cognitive impairment. These are proposed not only potential therapeutic targets but also biomarkers for In paper, we will begin review anatomy function EC, highlighting its selective vulnerability Subsequently, discuss disruption EC exploring changes neuronal oscillations during AD hypothesize that, considering advancements neuromodulation techniques, addressing disturbances activity could offer fresh insights both diagnosis treatment

Language: Английский

Citations

4
Phase-dependent closed-loop deep brain stimulation of the fornix provides bidirectional manipulation of hippocampal theta oscillations DOI Creative Commons

Isaac Grennan,

Brook A. L. Perry,

Anna Verghese

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases DOI
Siqi He, Weijie Jiang,

Baoyi Jiang

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5958 - 5973

Published: Jan. 23, 2024

Language: Английский

Citations

3
Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease DOI Creative Commons
Shuai Zhang,

Zhongsheng Guo,

Yihao Xu

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Feb. 7, 2024

Introduction In our study, we applied transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound within static magnetic field, in the APP/PS1 mouse model of Alzheimer's disease (AD) to explore feasibility TMAS improving AD related spatial memory deficits and abnormal neural oscillations. Methods The mice treated with once daily for 21 days. We recorded local field potential signals hippocampal CA1 region after treatment in-vivo electrophysiology evaluated rehabilitative effect sharp-wave ripple (SWR), gamma oscillations during SWRs, phase-amplitude coupling (PAC). function was examined by Morris water maze (MWM) task. Results found that improved performance MWM cognitive functions compared group. Furthermore, results implied alleviated abnormalities increased slow power promoted theta-slow coupling. These findings suggest could have positive influence through modulation Discussion This work emphasizes serve as non-invasive method rehabilitation promote application more neurological brain aging diseases future.

Language: Английский

Citations

3
Theta–gamma coupling as a ubiquitous brain mechanism: implications for memory, attention, dreaming, imagination, and consciousness DOI Creative Commons
Mauro Ursino, Gabriele Pirazzini

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 59, P. 101433 - 101433

Published: July 4, 2024

Brain rhythms are known to play a relevant role in many cognitive functions. In particular, coupling between theta and gamma oscillations was first observed the hippocampus, where it is assumed implement code for organizing multiple items memory. More recent advances, however, demonstrate that this mechanism ubiquitously present brain plays not only working memory but also episodic semantic memory, attention, emotion, dreaming, imagination. Furthermore, altered mental states neurological disorders show profound alterations theta–gamma code. review, which summarizes most experimental theoretical evidence, we suggest substantial capacity integrate information characteristic of entrainment fundamental implementing conscious processes.

Language: Английский

Citations

3
A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer’s disease DOI Creative Commons
Himanshu Joshi, Gowthami Nair,

Ashika Anne Roy

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Anodal transcranial direct current stimulation(tDCS) is known to improve cognition in patients with mild cognitive impairment (MCI) and Alzheimer’s disease(mild AD). We aimed examine the brain functional alterations accompanying improvement performance following anodal tDCS at left dorsolateral prefrontal cortex(DLPFC) a sample of early AD (N=40; MCI, n= 19 & AD, n=21) using magnetic resonance imaging (fMRI) magnetoencephalography(MEG). The showed significant improvements episodic memory, learning, delayed recall intervention. Significant (p-FDR < 0.05) reduction seed (left middle frontal gyrus, lMFG)-to-voxel resting state connectivity(rsFC) precuneus posterior cingulate gyrus(PCC) was noted intervention, while task-based fMRI(tbfMRI) analysis revealed increases blood oxygen level-dependent(BOLD) activations PCC right MFG(rMFG) during memory encoding retrieval tasks respectively. Furthermore, decrease MEG(rsMEG) gamma power occipital cortex an increase phase (theta) amplitude (gamma) coupling entorhinal were observed post-tDCS. findings this comprehensive study fMRI MEG, as well fMRI, provide mechanistic insights regarding that underlie modulatory effects AD.

Language: Английский

Citations

0
Olfactory bulb stimulation mitigates Alzheimer's‐like disease progression DOI Creative Commons
Morteza Salimi, Milad Nazari,

Payam Shahsavar

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(10)

Published: Oct. 1, 2024

Deep brain stimulation (DBS) has demonstrated potential in mitigating Alzheimer's disease (AD). However, the invasive nature of DBS presents challenges for its application. The olfactory bulb (OB), showing early AD-related changes and extensive connections with memory regions, offers an attractive entry point intervention, potentially restoring normal activity deteriorating circuits.

Language: Английский

Citations

3