bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 3, 2023
ABSTRACT
CDKL5
deficiency
disorder
(CDD)
is
a
neurodevelopmental
condition
characterized
by
global
developmental
delay,
early-onset
seizures,
intellectual
disability,
visual
and
motor
impairments.
Unlike
Rett
Syndrome
(RTT),
CDD
lacks
clear
regression
period.
patients
frequently
encounter
gastrointestinal
(GI)
disturbances
exhibit
signs
of
subclinical
immune
dysregulation.
However,
the
underlying
causes
these
conditions
remain
elusive.
Emerging
studies
indicate
potential
connection
between
neurological
disorders
gut
microbiota,
an
area
completely
unexplored
in
CDD.
We
conducted
pioneering
study,
analyzing
fecal
microbiota
composition
their
healthy
relatives.
Notably,
differences
intestinal
bacterial
diversity
were
identified
patients.
further
investigated
changes
based
on
severity
GI
issues,
seizure
frequency,
sleep
disorders,
food
intake
type,
impairment
neuro-behavioral
features
(assessed
through
RTT
Behaviour
Questionnaire
–
RSBQ),
ambulation
capacity.
Our
findings
hint
at
CDD,
symptom
severity.
This
study
marks
first
exploration
gut-microbiota-brain
axis
It
adds
to
growing
body
research
emphasizing
role
opens
doors
interventions
that
target
microbes
with
aim
improving
lives
Physiological Reviews,
Journal Year:
2024,
Volume and Issue:
104(3), P. 1205 - 1263
Published: March 14, 2024
Stress
resilience
is
the
phenomenon
that
some
people
maintain
their
mental
health
despite
exposure
to
adversity
or
show
only
temporary
impairments
followed
by
quick
recovery.
Resilience
research
attempts
unravel
factors
and
mechanisms
make
possible
harness
its
insights
for
development
of
preventative
interventions
in
individuals
at
risk
acquiring
stress-related
dysfunctions.
Biological
has
been
lagging
behind
psychological
social
sciences
but
seen
a
massive
surge
recent
years.
At
same
time,
progress
this
field
hampered
methodological
challenges
related
finding
suitable
operationalizations
study
designs,
replicating
findings,
modeling
animals.
We
embed
review
behavioral,
neuroimaging,
neurobiological,
systems
biological
findings
adults
critical
methods
discussion.
find
preliminary
evidence
hippocampus-based
pattern
separation
prefrontal-based
cognitive
control
functions
protect
against
pathological
fears
aftermath
singular,
event-type
stressors
[as
found
fear-related
disorders,
including
simpler
forms
posttraumatic
stress
disorder
(PTSD)]
facilitating
perception
safety.
Reward
system-based
pursuit
savoring
positive
reinforcers
appear
more
generalized
dysfunctions
anxious-depressive
spectrum
resulting
from
severe
longer-lasting
(as
depression,
comorbid
anxiety,
PTSD).
Links
between
preserved
functioning
these
neural
under
neuroplasticity,
immunoregulation,
gut
microbiome
composition,
integrity
barrier
blood-brain
are
beginning
emerge.
On
basis,
avenues
pointed
out.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(2), P. 73 - 73
Published: Jan. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7831 - 7831
Published: July 17, 2024
The
vagus
nerve
regulates
metabolic
homeostasis
and
mediates
gut–brain
communication.
We
hypothesized
that
dysfunction,
induced
by
truncated
vagotomy
(VGX)
or
carotid
artery
occlusion
(AO),
would
disrupt
communication
exacerbate
dysregulation,
neuroinflammation,
cognitive
impairment.
This
study
aimed
to
test
the
hypothesis
in
gerbils
fed
a
high-fat
diet.
were
divided
into
four
groups:
AO
with
VGX
(AO_VGX),
without
(AO_NVGX),
no
(NAO_VGX),
(NAO_NVGX).
After
5
weeks
on
diet,
neuronal
cell
death,
neurological
severity,
hippocampal
lipids
inflammation,
energy/glucose
metabolism,
intestinal
morphology,
fecal
microbiome
composition
assessed.
increased
death
severity
scores
associated
lipid
profiles
peroxidation,
as
well
changes
inflammatory
cytokine
expression
brain-derived
neurotrophic
factor
(BDNF)
levels.
also
body
weight,
visceral
fat
mass,
insulin
resistance
decreased
skeletal
muscle
mass.
morphology
altered,
an
increase
abundance
of
Bifidobacterium
decrease
Akkermansia
Ruminococcus.
Microbial
metagenome
functions
impacted,
including
glutamatergic
synaptic
activity,
glycogen
synthesis,
amino
acid
biosynthesis.
Interestingly,
effects
not
significantly
additive
AO,
suggesting
inhibited
partly
offsetting
VGX.
In
conclusion,
exacerbated
dysregulation
energy,
glucose,
memory
deficits,
potentially
through
modulation
axis.
Targeting
axis
inhibiting
suppression
represents
potential
therapeutic
strategy
for
ischemic
stroke.
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: Nov. 29, 2023
Cognitive
impairments,
such
as
learning
and
memory
deficits,
may
occur
in
susceptible
populations
including
the
elderly
patients
who
are
chronically
ill
or
have
experienced
stressful
events,
surgery,
infection,
trauma.
Accumulating
lines
of
evidence
suggested
that
peripheral
inflammation
featured
by
recruitment
immune
cells
release
pro-inflammatory
cytokines
be
activated
during
aging
these
conditions,
participating
system-brain
communication.
Lots
progress
has
been
achieved
deciphering
core
bridging
mechanism
connecting
cognitive
which
helpful
developing
early
diagnosis,
prognosis
evaluation,
prevention
methods
based
on
blood
circulation
system
sampling
intervention.
In
this
review,
we
summarized
evolving
prevalence
inflammation-associated
neurocognitive
impairments
discussed
research
advances
underlying
mechanisms.
We
also
highlighted
treatment
strategies
against
dysfunction.
Journal of Psychopharmacology,
Journal Year:
2024,
Volume and Issue:
38(4), P. 353 - 361
Published: March 26, 2024
Background:
The
microbiota–gut–brain
axis
(MGBA)
allows
bidirectional
crosstalk
between
the
brain
and
gut
microbiota
(GM)
is
believed
to
contribute
regulating
mood/cognition/behaviour/metabolism/health
homeostasis.
Manipulation
of
GM
through
faecal
transplant
(FMT)
a
new,
exciting
promising
treatment
for
major
depressive
disorder
(MDD).
Aims:
This
mini-review
examines
current
research
into
FMT
as
therapy
depression.
Methods:
Original
articles
published
in
Medline/Cochrane
Library/PubMed/EMBASE/PsycINFO
databases/National
Institute
Health
website
Clinicaltrials.gov/controlled-trials.com
were
searched.
Full
included
reference
lists
evaluated.
We
summarise
data
on
depression
discuss
communication
MGBA
interaction
antidepressants
this.
review
compositions
dysbiosis
depressed
cohorts,
focusing
future
directions
MDD.
Results:
Studies
have
demonstrated
significant
patients
compared
healthy
with
overgrowth
pro-inflammatory
microbiota,
reduction
anti-inflammatory
species
reduced
overall
stability
taxonomic
richness.
introduction
gastrointestinal
tract,
facilitating
restoration
eubiosis.
Conclusion:
plays
an
integral
role
human
health
disease
its
rest
body
via
MGBA.
may
provide
means
transfer
phenotype
recipient
this
concept
humans
attracting
enormous
attention
prospective
psychopathologies,
such
MDD,
future.
It
be
possible
manipulate
number
ways,
but
further
needed
determine
exact
likelihood
profiles
involved
development
amelioration
MDD
humans,
well
long-term
effects
potential
risks
procedure.
Neurobiology of Disease,
Journal Year:
2024,
Volume and Issue:
199, P. 106569 - 106569
Published: June 15, 2024
The
vagus
nerve
serves
as
an
interoceptive
relay
between
the
body
and
brain.
Despite
its
well-established
role
in
feeding
behaviors,
energy
metabolism,
cognitive
functions,
intricate
functional
processes
linking
to
hippocampus
contribution
learning
memory
dynamics
remain
still
elusive.
Here,
we
investigated
whether
how
gut-brain
vagal
axis
contributes
hippocampal
at
behavioral,
functional,
cellular,
molecular
levels.
Our
results
indicate
that
integrity
of
is
essential
for
long-term
recognition
memories,
while
sparing
other
forms
memory.
In
addition,
by
combing
multi-scale
approaches,
our
findings
show
tone
exerts
a
permissive
scaling
intracellular
signaling
events,
gene
expressions,
dendritic
spines
density
well
plasticities
(LTD
LTP).
These
highlight
critical
maintaining
spontaneous
homeostatic
functions
ensembles
regulating
their
functions.
conclusion,
study
provides
comprehensive
insights
into
multifaceted
involvement
shaping
time-dependent
dynamics.
Understanding
mechanisms
underlying
this
body-brain
neuronal
communication
may
pave
way
novel
therapeutic
approaches
conditions
associated
with
decline,
including
neurodegenerative
disorders.
