Task‐induced changes in brain entropy

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(2)

Published: Feb. 1, 2024

Entropy indicates irregularity of a dynamic system, with higher entropy indicating and more transit states. In the human brain, regional brain (BEN) has been increasingly assessed using resting state fMRI (rs-fMRI), while changes BEN during task-based have scarcely studied. The purpose this study is to characterize task-induced alterations large Human Connectome Project (HCP) data. To control potential modulation by block design, task-fMRI was calculated from images acquired task conditions only (task BEN) then compared rs-fMRI (resting BEN). Moreover, separately blocks runs (control BEN. Finally, test for residual effects in condition. With respect state, performance unanimously induced reduction peripheral cortical area increase centric part sensorimotor perception networks. Control showed similar alterations, suggesting effects. Task characterized reduced occipital, orbitofrontal, parietal regions.

Language: Английский

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The brain entropy dynamics in resting state

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 26, 2024

As a novel measure for irregularity and complexity of the spontaneous fluctuations brain activities, entropy (BEN) has attracted much attention in resting-state functional magnetic resonance imaging (rs-fMRI) studies during last decade. Previous have shown its associations with cognitive mental functions. While most previous research assumes BEN is approximately stationary scan sessions, brain, even at resting state, highly dynamic system. Such dynamics could be characterized by series reoccurring whole-brain patterns related to processes. The present study aims explore time-varying feature potential links general ability. We adopted sliding window approach derive dynamical (dBEN) networks from HCP (Human Connectome Project) rs-fMRI dataset that includes 812 young healthy adults. dBEN was further clustered into 4 states k-means clustering method. fraction (FW) mean dwell time (MDT) one extremely low overall BEN, were found negatively correlated abilities (i.e., flexibility, inhibitory control, processing speed). Another intermediate within-state located DMN, ECN, part SAN, FW, MDT positively above abilities. results our advance understanding underlying mechanism provide framework future investigations clinical populations.

Language: Английский

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rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area

Brain Structure and Function, Journal Year: 2025, Volume and Issue: 230(2)

Published: Jan. 27, 2025

Language: Английский

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The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN)

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00556 - e00556

Published: March 1, 2025

Intermittent theta burst stimulation (iTBS), a novel protocol within repetitive transcranial magnetic (rTMS), has shown superior therapeutic effects for depression compared to conventional high-frequency rTMS (HF-rTMS). However, the neural mechanisms underlying iTBS remain poorly understood. Brain entropy (BEN), measure of irregularity brain activity, recently emerged as promising marker regional function and demonstrated sensitivity HF-rTMS. Given its potential, BEN may help elucidate iTBS. In this study, we computed using resting-state fMRI data from sixteen healthy participants obtained OpenNeuro. Participants underwent over left dorsolateral prefrontal cortex (L-DLPFC) at two different intensities (90 ​% 120 resting motor threshold (rMT)) on separate days. We used 2 ​× ​2 repeated measures analysis variance (ANOVA) analyze interaction between intensity pre- vs. post-stimulation paired sample t-tests examine specific intensities. Additionally, spatial correlation was conducted determine whether altered baseline coupling neurotransmitter receptors/transporters, investigate potential changes induced by Our results indicate that subthreshold rMT) reduced striatal BEN, while suprathreshold (120 increased it. Subthreshold led in several receptor/transporter maps, primarily involving serotonin (5-HT), cannabinoid (CB), acetylcholine (ACh), glutamate (Glu). findings suggest is sensitive iTBS, with having distinct activity. Notably, offer more effective stimulation. This research highlights crucial role modulating activity lays groundwork future clinical studies focused optimizing outcomes through precise intensity.

Language: Английский

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Lower resting brain entropy is associated with stronger task activation and deactivation

NeuroImage, Journal Year: 2022, Volume and Issue: 249, P. 118875 - 118875

Published: Jan. 5, 2022

Brain entropy (BEN) calculated from resting state fMRI has been the subject of increasing research interest in recent years. Previous studies have shown correlations between rest BEN and neurocognition task performance, but how this relates to task-evoked brain activations deactivations remains unknown. The purpose study is address open question using large data (n = 862). Voxel wise were activations/deactivations five different tasks. For most assessed tasks, lower was found be associated with stronger (negative correlations) (positive only regions activated or deactivated by Higher workload evoked spatially more extended negative activations. These results not confirm that activity can predict during performance also for first time show may facilitate both deactivations. In addition, provide a clue understanding individual differences

Language: Английский

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Cognitive protection and brain entropy changes from omega-3 polyunsaturated fatty acids supplement in late-life depression: A 52-week randomized controlled trial

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 351, P. 15 - 23

Published: Jan. 26, 2024

Language: Английский

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Associations of Brain Entropy Estimated by Resting State fMRI With Physiological Indices, Body Mass Index, and Cognition

Journal of Magnetic Resonance Imaging, Journal Year: 2023, Volume and Issue: 59(5), P. 1697 - 1707

Published: Aug. 14, 2023

In recent years, resting-state fMRI (rsfMRI)-based brain entropy (BEN) has gained increasing interest as a tool to characterize activity. While previous studies indicate that BEN is correlated with cognition, it remains unclear whether influenced by other factors typically affect activity measured fMRI.

Language: Английский

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Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts

Medical & Biological Engineering & Computing, Journal Year: 2023, Volume and Issue: 61(12), P. 3159 - 3166

Published: Sept. 18, 2023

Language: Английский

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Increased Resting Brain Entropy in Mild to Moderate Depression was Decreased by Nonpharmacological Treatment

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 27, 2024

Abstract Entropy indicates systematic irregularity and information capacity. Recent years have seen increasing interest in assessing regional brain entropy (BEN) using fMRI healthy controls (HCs) patients with various diseases. Depression anti-depressant related BEN alterations been reported several initial studies. Re-examining these effects independent cohort is crucial given the high complexity of depression. In this study, we used open data from OpenNeuro 46 mild to moderate depression 20 HCs examine its changes due nonpharmacological treatment (14 underwent treatment). Functional connectivity (FC) analysis was performed assess inter-regional relationship between regions showing rest brain. Compared HCs, showed increased left DLPFC, precuneus, limbic system, including amygdala, parahippocampal gyrus hippocampus. Increased amygdala were suppressed by a each individual patient. had positive FC right DLPFC negative areas, while abnormally lower or area. These seeded reverted after treatment. The findings highlight system effects, exhibit significant emotion dysregulation, which effectively addressed targeting top-down regulation functions mediated DLPFC-limbic system. Different existing literature, results suggest entropy/irregularity as potential mechanism underlying personalized marker for corresponding effects.

Language: Английский

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rsfMRI-based Brain Entropy is negatively correlated with Gray Matter Volume and Surface Area

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

In recent years, brain entropy (BEN) has been ossociated with a number of neurocognitive, biological, and sociodemographic variables. However, its link morphology is still unknown. this study, we use resting-state fMRI (rsfMRI) data to estimate BEN maps investigate their associations three metrics morphology: gray matter volume (GMV), surface area (SA), cortical thickness (CT). Separate analyses will be performed on derived from four distinct rsfMRI runs, using both voxelwise regions interest (ROIs) approach. Our findings consistently showed that lower (i.e., higher temporal coherence activity) was related increased GMV SA in the lateral frontal lobes, inferior parietal lobules, precuneus. We hypothesize might reflect reserve as well information processing capacity.

Language: Английский

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