The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Journal Year: 2013, Volume and Issue: 14(9), P. 609 - 625

Published: Aug. 14, 2013

Language: Английский

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Neuronal circuits for fear and anxiety

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(6), P. 317 - 331

Published: May 20, 2015

Language: Английский

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The Mysterious Motivational Functions of Mesolimbic Dopamine

Neuron, Journal Year: 2012, Volume and Issue: 76(3), P. 470 - 485

Published: Nov. 1, 2012

Language: Английский

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Input-specific control of reward and aversion in the ventral tegmental area

Nature, Journal Year: 2012, Volume and Issue: 491(7423), P. 212 - 217

Published: Oct. 12, 2012

Language: Английский

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Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics

Science, Journal Year: 2013, Volume and Issue: 340(6129), P. 211 - 216

Published: April 11, 2013

Successful integration of advanced semiconductor devices with biological systems will accelerate basic scientific discoveries and their translation into clinical technologies. In neuroscience generally, in optogenetics particular, the ability to insert light sources, detectors, sensors, other components precise locations deep brain yields versatile important capabilities. Here, we introduce an injectable class cellular-scale optoelectronics that offers such features, examples unmatched operational modes optogenetics, including completely wireless programmed complex behavioral control over freely moving animals. The these ultrathin, mechanically compliant, biocompatible afford minimally invasive operation soft tissues mammalian foreshadow applications organ systems, potential for broad utility biomedical science engineering.

Language: Английский

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Neuronal Reward and Decision Signals: From Theories to Data

Physiological Reviews, Journal Year: 2015, Volume and Issue: 95(3), P. 853 - 951

Published: June 25, 2015

Rewards are crucial objects that induce learning, approach behavior, choices, and emotions. Whereas emotions difficult to investigate in animals, the learning function is mediated by neuronal reward prediction error signals which implement basic constructs of reinforcement theory. These found dopamine neurons, emit a global signal striatum frontal cortex, specific neurons striatum, amygdala, cortex projecting select populations. The choice functions involve subjective value, objectively assessed behavioral choices eliciting internal, preferences. Utility formal mathematical characterization value prime decision variable economic It coded as utility phasic responses. can incorporate various influences, including risk, delay, effort, social interaction. Appropriate for mechanisms, rewards object action difference chosen neurons. Although all reward, reinforcement, variables theoretical constructs, their constitute measurable physical implementations such confirm validity these concepts. provide guidance behavior while constraining free will act.

Language: Английский

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Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

Nature reviews. Neuroscience, Journal Year: 2017, Volume and Issue: 18(2), P. 73 - 85

Published: Jan. 5, 2017

Language: Английский

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Dopamine neurons modulate neural encoding and expression of depression-related behaviour

Nature, Journal Year: 2012, Volume and Issue: 493(7433), P. 537 - 541

Published: Dec. 11, 2012

Language: Английский

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Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

Science, Journal Year: 2018, Volume and Issue: 360(6396)

Published: May 31, 2018

Imaging dopamine release in the brain Neuromodulator alters function of target circuits poorly known ways. An essential step to address this knowledge gap is measure dynamics neuromodulatory signals while simultaneously manipulating elements circuit during behavior. Patriarchi et al. developed fluorescent protein–based indicators visualize spatial and temporal directly with high fidelity resolution. In cortex, two-photon imaging these was used map activity at cellular Science , issue p. eaat4422

Language: Английский

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Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping

Cell, Journal Year: 2015, Volume and Issue: 162(3), P. 622 - 634

Published: July 1, 2015

Language: Английский

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