The hippocampal CA2 region is essential for social memory

Nature, Journal Year: 2014, Volume and Issue: 508(7494), P. 88 - 92

Published: Feb. 21, 2014

Language: Английский

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Striatal circuits for reward learning and decision-making

Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(8), P. 482 - 494

Published: June 6, 2019

Language: Английский

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A comprehensive excitatory input map of the striatum reveals novel functional organization

eLife, Journal Year: 2016, Volume and Issue: 5

Published: Nov. 28, 2016

The striatum integrates excitatory inputs from the cortex and thalamus to control diverse functions. Although is thought consist of sensorimotor, associative limbic domains, their precise demarcations whether additional functional subdivisions exist remain unclear. How striatal are differentially segregated into each domain also poorly understood. This study presents a comprehensive map mouse striatum. input patterns reveal boundaries between known domains. most posterior likely represents 4th subdivision, dorsomedial highly heterogeneous, multimodal inputs. complete thalamo-cortico-striatal loop presented, which reveals that thalamic subregions innervated by basal ganglia preferentially interconnect with motor-related cortical areas. Optogenetic experiments show subregion-specific heterogeneity in synaptic properties both thalamus. projectome will guide studies investigating

Language: Английский

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Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease

Progress in Neurobiology, Journal Year: 2015, Volume and Issue: 132, P. 96 - 168

Published: July 22, 2015

Language: Английский

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A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei

Neuron, Journal Year: 2014, Volume and Issue: 83(3), P. 663 - 678

Published: Aug. 1, 2014

Language: Английский

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Monosynaptic Circuit Tracing with Glycoprotein-Deleted Rabies Viruses

Journal of Neuroscience, Journal Year: 2015, Volume and Issue: 35(24), P. 8979 - 8985

Published: June 17, 2015

### Introduction Since the introduction of methods using glycoprotein (G)-deleted rabies virus (RV dG ) to identify direct monosynaptic inputs genetically targeted neurons eight years ago ([Wickersham et al., 2007b][1]), this approach has been widely used for sophisticated circuit-tracing

Language: Английский

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The ins and outs of the striatum: Role in drug addiction

Neuroscience, Journal Year: 2015, Volume and Issue: 301, P. 529 - 541

Published: June 24, 2015

Language: Английский

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Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia

Cell, Journal Year: 2016, Volume and Issue: 164(3), P. 526 - 537

Published: Jan. 1, 2016

The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions not well understood. Here, we dissect mechanisms BG direct and indirect pathway-mediated control mesencephalic locomotor region (MLR), a brainstem that is locomotion. We optogenetically function three neurochemically distinct cell types within MLR: glutamatergic, GABAergic, cholinergic neurons. find glutamatergic subpopulation encodes state speed, necessary sufficient locomotion, selectively innervated by BG. further show activation suppression, respectively, MLR neurons pathways, which required bidirectional locomotion circuits. These findings provide fundamental understanding how can initiate or suppress program through cell-type-specific regulation linked to specific actions.

Language: Английский

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Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Neurobiology of Disease, Journal Year: 2015, Volume and Issue: 82, P. 185 - 199

Published: June 17, 2015

Language: Английский

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The Basal Ganglia Over 500 Million Years

Current Biology, Journal Year: 2016, Volume and Issue: 26(20), P. R1088 - R1100

Published: Oct. 1, 2016

Language: Английский

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