Prefrontal cortex, amygdala, and threat processing: implications for PTSD

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(1), P. 247 - 259

Published: Sept. 20, 2021

Abstract Posttraumatic stress disorder can be viewed as a of fear dysregulation. An abundance research suggests that the prefrontal cortex is central to processing—that is, how fears are acquired and strategies regulate or diminish responses. The current review covers foundational on threat acquisition extinction in nonhuman animals, healthy humans, patients with posttraumatic disorder, through lens involvement these processes. Research harnessing advances technology further probe role processes, such use optogenetics rodents brain stimulation will highlighted, well other regulation approaches relevant treatment involve cortex, namely cognitive avoidance/active coping. Despite large body translational research, many questions remain unanswered remains difficult treat. We conclude by outlining future directions related processing implications for disorder.

Language: Английский

---

Relations between emotion regulation strategies and affect in daily life: A systematic review and meta-analysis of studies using ecological momentary assessments

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 139, P. 104747 - 104747

Published: June 16, 2022

Emotion regulation (ER) is a central target in the study of psychological and neurobiological processes emotions for numerous disorders. Ecological momentary assessments, overcoming retrospective self-reports, allow better understanding relation between use ER strategies daily life affective experiences. A systematic review meta-analyses studies testing these relations through experience sampling methods (ESM) diaries were conducted. ESM showed significant large effect sizes contemporaneous negative affect (NA) rumination, suppression, worry, both prospective positive (PA) reappraisal; medium NA PA distraction; small size suppression. Daily diary rumination acceptance, problem-solving; reappraisal. These findings shed light on temporal experiences highlight conceptual methodological limitations field.

Language: Английский

---

EEG emotion recognition using attention-based convolutional transformer neural network

Biomedical Signal Processing and Control, Journal Year: 2023, Volume and Issue: 84, P. 104835 - 104835

Published: March 10, 2023

Language: Английский

---

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial

Cognitive Affective & Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 23(1), P. 66 - 83

Published: Sept. 15, 2022

Language: Английский

---

The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 43(9), P. 2898 - 2910

Published: March 9, 2022

Abstract The ventrolateral prefrontal cortices (VLPFC) are crucial regions involved in voluntary emotion regulation. However, the lateralization of VLPFC downregulating negative emotions remains unclear; and whether causal role is generalizable to upregulating positive unexplored. This study used transcranial magnetic stimulation (TMS) examine relationship between left/right social reappraisal. One hundred twenty participants were randomly assigned either active (left right groups, n = 40/40) or sham (vertex, 40) TMS groups. Participants instructed passively receive feedback use reappraisal strategies positively regulate their emotions. While subjective emotional rating showed that bilateral facilitated success, electrophysiological measure late potential (LPP) demonstrated a more critical on pain relief (decreased LPP amplitudes) reward magnification (enhanced amplitudes). In addition, influence regulation evaluation was found be mediated by memory feedback, indicating importance behavioral shaping. These findings suggest clinical protocols for rehabilitation emotion‐regulatory function patients with affective disorders.

Language: Английский

---

Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114647 - 114647

Published: April 1, 2023

With rapid aging of the population worldwide, number people with dementia is dramatically increasing. Some studies have emphasized that metabolic syndrome, which includes obesity and diabetes, leads to increased risks cognitive decline. Factors such as insulin resistance, hyperglycemia, high blood pressure, dyslipidemia, central in syndrome are associated synaptic failure, neuroinflammation, imbalanced neurotransmitter levels, leading progression dementia. Due positive correlation between diabetes dementia, some called it "type 3 diabetes". Recently, patients decline due imbalances has considerably increased. In addition, recent reported neuropsychiatric issues anxiety, depressive behavior, impaired attention common factors disease those nervous system (CNS), amygdala a region regulates emotional memory, mood disorders, attention, function. The connectivity other brain regions, hippocampus, activity contribute diverse neuropathological issues. Thus, this review summarizes significant consequences critical roles both syndromes Further on function imbalance-related needed treat problems type

Language: Английский

---

Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Neuronal Signaling, Journal Year: 2023, Volume and Issue: 7(4)

Published: Oct. 27, 2023

Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Language: Английский

---

Neural underpinnings of individual differences in emotion regulation: A systematic review

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 162, P. 105727 - 105727

Published: May 15, 2024

This review synthesises individual differences in neural processes related to emotion regulation (ER). It comprises self-reported and physiological success, ER-related traits, demographic variables, assess their correlation with brain activation during ER tasks. Considering region-of-interest (ROI) whole-brain analyses, the incorporated data from 52 functional magnetic resonance imaging studies. Results can be summarized as follows: (1) Self-reported success (assessed by emotional state ratings after regulation) traits questionnaires) correlated activity lateral prefrontal cortex. (2) Amygdala only ROI while it was associated analyses. (3) For measures, there no systematic overlap effects reported across In showing that traced back of regions reactivity (amygdala) cognitive control (lateral cortex), our findings inform prospective personalised intervention models.

Language: Английский

---

Association of Optimism with Cardiovascular Events and All-Cause Mortality: Systematic Review and Meta-Analysis

The American Journal of Medicine, Journal Year: 2022, Volume and Issue: 135(7), P. 856 - 863.e2

Published: Feb. 4, 2022

Language: Английский

---

Neural correlations between cognitive deficits and emotion regulation strategies: understanding emotion dysregulation in depression from the perspective of cognitive control and cognitive biases

Deleted Journal, Journal Year: 2022, Volume and Issue: 2(3), P. 86 - 99

Published: Sept. 1, 2022

The link between cognitive function and emotion regulation may be helpful in better understanding the onset, maintenance, treatment for depression. However, it remains unclear whether there are neural correlates dysregulation deficits To address this question, we first review representations of depression (including control biases). Based on comparisons versus deficits, propose an accessible reasonable dysregulation, control, biases Specifically, serves whole process regulation, whereas engaged processes at different stages. Moreover, abnormal implementation strategies is consistently affected by which involved dorsolateral, dorsomedial prefrontal cortex, anterior cingulate cortex. Besides, relationship distinct: orbitofrontal cortex contributes to association ineffective reappraisal negative interpretation bias, while subgenual posterior underline tendency depressed individuals ruminate overly engage self-referential bias. This sheds light identifies directions need future attention.

Language: Английский

---