Abstract
With
the
development
of
technology,
biosensors
are
increasingly
used
in
biomedical
field.
Due
to
high
sensitivity
optical
signals,
good
stability,
signal‐to‐noise
ratio,
and
different
spectral
characteristics
analytes,
can
achieve
direct
real‐time
detection
analytes
with
specificity
compared
traditional
analytical
techniques.
In
view
rapid
for
vivo
applications
their
promising
future,
we
have
attempted
summarize
working
principles
recent
advances
application
humans,
aim
helping
readers
gain
an
in‐depth
detailed
understanding
developed
years
biological
living
body.
this
review,
focus
on
some
current
widely
biosensors,
including
colorimetric
fluorescence
surface‐enhanced‐Raman‐scattering‐based
biosensors.
The
each
type
biosensor
concisely
described
body
is
summarized
by
category.
We
conclude
looking
at
prospects
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 976 - 976
Published: March 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 18, 2025
Clinically,
multimodal
therapies
are
adopted
worldwide
for
the
management
of
cancer,
which
continues
to
be
a
leading
cause
death.
In
recent
years,
immunotherapy
has
firmly
established
itself
as
new
paradigm
in
cancer
care
that
activates
body's
immune
defense
cope
with
cancer.
Immunotherapy
resulted
significant
breakthroughs
treatment
stubborn
tumors,
dramatically
improving
clinical
outcome
patients.
Multiple
forms
immunotherapy,
including
checkpoint
inhibitors
(ICIs),
adoptive
cell
therapy
and
vaccines,
have
become
widely
available.
However,
effectiveness
these
immunotherapies
is
not
much
satisfying.
Many
patients
do
respond
disease
recurrence
appears
unavoidable
because
rapidly
evolving
resistance.
Moreover,
can
give
rise
severe
off-target
immune-related
adverse
events.
Strategies
remove
hindrances
mainly
focus
on
development
combinatorial
or
exploitation
novel
immunotherapeutic
mediations.
Nanomaterials
carrying
anticancer
agents
target
site
considered
practical
approaches
treatment.
Nanomedicine
combined
offers
possibility
potentiate
systemic
antitumor
immunity
facilitate
selective
cytotoxicity
against
cells
an
effective
safe
manner.
A
myriad
nano-enabled
currently
under
investigation.
Owing
gaps
between
preclinical
studies,
nano-immunotherapy
faces
multiple
challenges,
biosafety
nanomaterials
trial
design.
this
review,
we
provide
overview
summarize
evidence
indicating
how
nanomedicine-based
increase
efficacy
immunotherapies.
We
also
discuss
key
challenges
emerged
era
nanotechnology-based
immunotherapy.
Taken
together,
combination
drawing
increasing
attention,
it
anticipated
will
achieve
desired
success
therapy.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101626 - 101626
Published: March 1, 2025
Cancer
treatment
is
challenged
by
the
tumor
microenvironment
(TME),
which
promotes
drug
resistance
and
cancer
cell
growth.
This
review
offers
a
comprehensive
innovative
perspective
on
how
nanomedicine
can
modify
TME
to
enhance
therapy.
Strategies
include
using
nanoparticles
improve
oxygenation,
adjust
acidity,
alter
extracellular
matrix,
making
treatments
more
effective.
Additionally,
immune
responses
activating
cells
reducing
suppression
within
tumors.
By
integrating
these
approaches
with
existing
therapies,
such
as
chemotherapy
radiotherapy,
show
promise
in
overcoming
traditional
barriers.
The
discusses
changes
effectiveness
of
itself,
creating
reciprocal
relationship
that
boosts
overall
efficacy.
We
also
highlight
novel
strategies
aimed
at
exploiting
TME,
leveraging
nanoparticle-based
for
targeted
therapy
through
precise
modulation.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(9), P. 1919 - 1919
Published: Sept. 11, 2022
Tumor-targeted
therapy
based
on
nanoparticles
is
a
popular
research
direction
in
the
biomedical
field.
After
decades
of
and
development,
both
passive
targeting
ability
inherent
properties
NPs
active
ligand
receptor
interaction
have
gained
deeper
understanding.
Unfortunately,
most
targeted
delivery
strategies
are
still
preclinical
trial
stage,
so
it
necessary
to
further
study
biological
fate
particles
vivo
mechanism
with
tumors.
This
article
reviews
different
NPs,
focuses
physical
chemical
(size,
morphology,
surface
intrinsic
properties),
ligands
(binding
number/force,
activity
species)
receptors
(endocytosis,
distribution
recycling)
other
factors
that
affect
particle
targeting.
The
limitations
solutions
these
discussed,
variety
new
schemes
introduced,
hoping
provide
guidance
for
future
design
achieve
purpose
rapid
transformation
into
clinical
application.
European journal of medical research,
Journal Year:
2023,
Volume and Issue:
28(1)
Published: Nov. 24, 2023
Abstract
This
paper
gives
a
detailed
analysis
of
nanotechnology's
rising
involvement
in
numerous
surgical
fields.
We
investigate
the
use
nanotechnology
orthopedic
surgery,
neurosurgery,
plastic
oncology,
heart
vascular
ophthalmic
thoracic
and
minimally
invasive
surgery.
The
details
how
helps
with
arthroplasty,
chondrogenesis,
tissue
regeneration,
wound
healing,
more.
It
also
discusses
employment
nanomaterials
implant
surfaces,
bone
grafting,
breast
implants,
among
other
things.
article
explores
various
uses,
including
stem
cell-incorporated
nano
scaffolds,
nano-surgery,
hemostasis,
nerve
nanorobots,
diagnostic
applications.
ethical
safety
implications
using
surgery
are
addressed.
future
possibilities
investigated,
pointing
to
possible
route
for
improved
patient
outcomes.
essay
finishes
comment
on
transformational
influence
applications
its
promise
breakthroughs.
Graphical
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(12)
Published: Jan. 11, 2024
Abstract
Brain
cancers,
especially
glioblastoma
multiforme,
are
associated
with
poor
prognosis
due
to
the
limited
efficacy
of
current
therapies.
Nanomedicine
has
emerged
as
a
versatile
technology
treat
various
diseases,
including
and
played
an
indispensable
role
in
combatting
COVID‐19
pandemic
evidenced
by
that
lipid
nanocarrier‐based
vaccines
have
played.
The
tunability
nanocarrier
physicochemical
properties
—including
size,
shape,
surface
chemistry,
drug
release
kinetics—
resulted
development
wide
range
nanocarriers
for
brain
cancer
treatment.
These
can
improve
pharmacokinetics
drugs,
increase
blood‐brain
barrier
transfer
efficiency,
specifically
target
cells.
unique
features
would
potentially
allow
more
efficient
treatment
fewer
side
effects
better
therapeutic
outcomes.
This
review
provides
overview
options,
challenges
latest
advances
nanomedicine
strategies
investigated
emphasis
on
targeted
stimulus‐responsive
their
potential
clinical
translation.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: April 29, 2024
Catalytic
nanoparticles
(CNPs)
as
heterogeneous
catalyst
reveals
superior
activity
due
to
their
physio-chemical
features,
such
high
surface-to-volume
ratio
and
unique
optical,
electric,
magnetic
properties.
The
CNPs,
based
on
nature,
can
either
increase
the
reactive
oxygen
species
(ROS)
level
for
tumor
antibacterial
therapy
or
eliminate
ROS
cytoprotection,
anti-inflammation,
anti-aging.
In
addition,
catalytic
of
nanozymes
specifically
trigger
a
specific
reaction
accompanied
by
optical
feature
change,
presenting
feasibility
biosensor
bioimaging
applications.
Undoubtedly,
CNPs
play
pivotal
role
in
pushing
evolution
technologies
medical
clinical
fields,
advanced
strategies
nanomaterials
rely
input
chemical
experts
develop.
Herein,
systematic
comprehensive
review
challenges
recent
development
biomedical
applications
is
presented
from
viewpoint
nanomaterial
with
additional
functions.
Furthermore,
biosafety
issue
applying
biodegradable
non-biodegradable
future
perspectives
are
critically
discussed
guide
promising
direction
developing
span-new
more
intelligent
overcoming
current
limitations.
