Food Bioscience, Journal Year: 2025, Volume and Issue: 65, P. 106017 - 106017
Published: Jan. 31, 2025
Language: Английский
Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2021, Volume and Issue: 209, P. 114477 - 114477
Published: Nov. 28, 2021
Language: Английский
Citations
326
Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 60 - 60
Published: Dec. 28, 2021
Muscle foods and their products are a fundamental part of the human diet. The high protein content found in muscle foods, as well essential amino acids, provides an appropriate composition to complete nutritional requirements humans. However, due special composition, they susceptible oxidative degradation. In this sense, proteins highly reactions. contrast lipid oxidation, which has been studied depth for decades, oxidation investigated much less. Moreover, these reactions have important influence on quality from physico-chemical, techno-functional, perspectives. regard, loss nutrients, impairment texture, water-holding capacity, color flavor, formation toxic substances some direct consequences oxidation. results consumer rejection substantial levels economic losses, thus control processes is vital importance food industry. Nonetheless, complexity involved many different factors that make mechanisms difficult fully understand. Therefore, present manuscript reviews most reactions, main currently available analytical methods quantify compounds derived Finally, effects both physico-chemical points view, also discussed.
Language: Английский
Citations
217
Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 548 - 548
Published: Feb. 21, 2023
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung injury can affect several components respiratory system, including airways, parenchyma, pulmonary vasculature. Although acute represent an enormous economic clinical burden, currently available therapies primarily focus on alleviating disease symptoms rather than reversing and/or preventing pathology. Moreover, some supportive interventions, such as oxygen mechanical ventilation, lead to (further) deterioration function even development permanent injuries. Lastly, sepsis, which originate extrapulmonary or in system itself, contributes many cases lung-associated deaths. Considering these challenges, we aim summarize molecular cellular mechanisms, with a particular airway inflammation oxidative stress that characteristic pathophysiology In addition, will highlight limitations current therapeutic strategies explore new antioxidant-based drug options could potentially be effective managing
Language: Английский
Citations
110
Cell Proliferation, Journal Year: 2023, Volume and Issue: 56(9)
Published: March 13, 2023
Abstract Low back pain (LBP) is a leading cause of labour loss and disability worldwide, it also imposes severe economic burden on patients society. Among symptomatic LBP, approximately 40% caused by intervertebral disc degeneration (IDD). IDD the pathological basis many spinal degenerative diseases such as herniation stenosis. Currently, therapeutic approaches for mainly include conservative treatment surgical treatment, neither which can solve problem from root terminating process (IVD). Therefore, further exploring pathogenic mechanisms adopting targeted strategies one current research hotspots. complex pathophysiological processes IDD, oxidative stress considered main factor. The delicate balance between reactive oxygen species (ROS) antioxidants essential maintaining normal function survival IVD cells. Excessive ROS levels damage to macromolecules nucleic acids, lipids, proteins cells, affect cellular activities functions, ultimately lead cell senescence or death. This review discusses potential role in understand provides IDD.
Language: Английский
Citations
87
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 1869 - 1869
Published: Jan. 18, 2023
Aging is the most prominent risk factor for late-onset Alzheimer’s disease. associates with a chronic inflammatory state both in periphery and central nervous system, evidence thereof mechanisms leading to neuroinflammation being discussed. Nonetheless, significantly enhanced by accumulation of amyloid beta accelerates progression disease through various pathways discussed present review. Decades clinical trials targeting 2 abnormal proteins disease, tau, led many failures. As such, via different strategies could prove valuable therapeutic strategy, although much research still needed identify appropriate time window. Active focusing on identifying early biomarkers help translating these novel from bench bedside.
Language: Английский
Citations
84
Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1153 - 1153
Published: June 13, 2022
Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading synovitis bone cartilage degradation. Reactive oxygen species (ROS) are commonly used as destructive or modifying agents cellular components they act signaling molecules in the system. During development RA, hypoxic situation synovium maintains ROS generation, which can be sustained by increased DNA damage malfunctioning mitochondria feedback loop. Oxidative stress caused abundant production has also been shown associated RA. The goal this review examine functions related molecular mechanisms diverse cells synovial microenvironment strategies relying on regulating treat RA reviewed.
Language: Английский
Citations
75
Biogerontology, Journal Year: 2023, Volume and Issue: 24(5), P. 609 - 662
Published: July 30, 2023
Language: Английский
Citations
75
Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(16), P. 9720 - 9785
Published: July 17, 2023
Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced transformations biological systems. Understanding their mode of action is essential for advancing fields such as photomedicine, photoredox catalysis, environmental science, the development sun care products. This review offers comprehensive analysis endogenous human skin, investigating connections between electronic excitation subsequent activation or damage organic biomolecules. We gather physicochemical photochemical properties key examine relationships chemical reactivity, location within primary biochemical events following solar radiation exposure, along with influence on skin physiology pathology. An important take-home message this that photosensitization allows visible light UV-A to have large effects skin. The presented here unveils potential causes continuous increase global cancer cases emphasizes limitations current protection approaches.
Language: Английский
Citations
48
Journal of Membrane Science, Journal Year: 2023, Volume and Issue: 677, P. 121611 - 121611
Published: March 28, 2023
Language: Английский
Citations
45
Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1250 - 1250
Published: June 10, 2023
Cellular senescence, a cell state characterized by generally irreversible cycle arrest, is implicated in various physiological processes and wide range of age-related pathologies. Oxidative stress, condition caused an imbalance between the production elimination reactive oxygen species (ROS) cells tissues, common driver cellular senescence. ROS encompass free radicals other molecules formed as byproducts metabolism, which exhibit varying chemical reactivity. A prerequisite for generation strong oxidizing that can damage macromolecules impair function availability labile (redox-active) iron, catalyzes formation highly radicals. Targeting iron has been proven effective strategy to counteract adverse effects ROS, but evidence concerning senescence sparse. In present review article, we discuss aspects oxidative stress-induced with special attention potential implication iron.
Language: Английский
Citations
44