The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2 DOI Creative Commons
Hui Huang, Yuqin Shi, Yuequan Zhou

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

Acute lung injury (ALI), one of the most severe respiratory system diseases, is prevalent worldwide. Annexin A1 (AnxA1) an important member annexin superfamily, known for its wide range physiological functions. However, potential protective effect against lipopolysaccharide (LPS)-induced ALI remains unclear. Mice were divided into four groups: Sham, LPS + vehicle, 0.1 μg AnxA1, and 0.5 AnxA1. Lung was assessed through histopathology, pulmonary wet-to-dry (W/D) ratio, cell counting bronchoalveolar lavage fluid (BALF), oxidative stress analysis, noninvasive function testing. Gene protein expression levels measured using RT-PCR, ELISA, western blot analysis. AnxA1 alleviated LPS-induced by protecting tissue from damage, reducing wet/dry weight improving impaired function. Interestingly, administration found to repress infiltration inflammatory cells decreasing total count, neutrophils, concentrations in (BALF). mitigated response lowering IL-1β, IL-6, TNF-α BALF mice. Additionally, attenuated tissues mice restoring activity catalase (CAT), SOD, glutathione (GSH) but malondialdehyde (MDA). We also that suppressed activation NLRP3 signaling pathway. Mechanistically, activated Nrf2/HO-1 pathway while preventing NF-κB. Collectively, these findings suggest alleviates might be a promising novel therapeutic agent ALI.

Language: Английский

COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

Citations

58
A Comprehensive Review of Free Radicals, Oxidative Stress, and Antioxidants: Overview, Clinical Applications, Global Perspectives, Future Directions, and Mechanisms of Antioxidant Activity of Flavonoid Compounds DOI Creative Commons
Sefren Geiner Tumilaar, Ari Hardianto, Hirofumi Dohi

et al.

Journal of Chemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 21

Published: May 31, 2024

Absorption​ of free radicals in the body cannot be done by antioxidant compounds originating from human body, so exogenous antioxidants are required to help their natural action. Oxidative stress can caused an imbalance radical inhibitors and accumulation that enter cellular structures. Synthetic found external not primary choice because they harmful carcinogenic. Therefore, using ingredients provides a necessary alternative constructing novel antioxidants. Recent studies have highlighted critical analysis evaluation flavonoids unique class secondary metabolites plants used communities as traditional therapeutics with proven bioactivity. This could support new discoveries based on various herbal medicines addition, functional effectiveness against radicals. In this review, there several strengths discussion. First, study takes comprehensive approach covering aspects, including properties sources radicals, oxidative relation different diseases, defense mechanisms, specific mechanisms flavonoids. Second, focus antioxidants, especially flavonoids, also discussion about clinical applications studies, limitations, global perspectives, future research directions become references selection medicines. But, constraints should considered when interpreting findings review. mechanism is only discussed general one example compound (flavonoid) has potential antioxidant. lack regarding relationship between diseases Third, limited number investigated some discussed.

Language: Английский

Citations

29
The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ahsas Goyal

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 111002 - 111002

Published: April 9, 2024

Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates morbidity death across many demographic groups. An industrial chemical common environmental contaminant, formaldehyde (FA) presents serious concerns to the respiratory system, including onset aggravation lung disorders. Epidemiological studies have shown significant associations between FA exposure levels incidence severity several diseases. causes inflammation in tract via immunological activation, oxidative stress, airway remodelling, aggravating pre-existing pulmonary compromising function. Additionally, functions as sensitizer, causing allergic responses hypersensitivity pneumonitis sensitive people. Understanding complicated processes behind formaldehyde-induced is critical for directing targeted strategies aimed at minimizing exposures alleviating burden formaldehyde-related illnesses on health. This abstract explores intricate relationship diseases, asthma, bronchitis, inflammation, injury fibrosis.

Language: Английский

Citations

22
Arginine methyltransferase PRMT1 promotes ferroptosis through EGR1/GLS2 axis in sepsis-related acute lung injury DOI Creative Commons
Min Li,

Longhui Hu,

Ke Qiao

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 3, 2025

Language: Английский

Citations

2
Oxidative stress in the brain–lung crosstalk: cellular and molecular perspectives DOI Creative Commons
Jianda Kong,

Rao Fan,

Yuanqi Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: April 3, 2024

Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and body’s ability to counteract their harmful effects, playing a key role in pathogenesis brain lung-related diseases. This review comprehensively examines intricate mechanisms which oxidative influences cellular molecular pathways, contributing neurodegenerative, cardiovascular, respiratory disorders. Emphasizing detrimental effects on both lung health, we discuss innovative diagnostic biomarkers, such as 8-hydroxy-2′-deoxyguanosine (8-OHdG), potential antioxidant therapies. For these topics, provide insights into future research directions field treatment, including development personalized treatment approaches, discovery validation novel new drug delivery systems. not only provides perspective understanding diseases but also offers for clinical treatments.

Language: Английский

Citations

10
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective DOI Open Access
Pierachille Santus,

Juan Camilo Signorello,

Fiammetta Danzo

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4127 - 4127

Published: July 15, 2024

N-acetyl-L-cysteine (NAC) was initially introduced as a treatment for mucus reduction and widely used chronic respiratory conditions associated with overproduction. However, the mechanism of action NAC extends beyond its mucolytic activity is complex multifaceted. Contrary to other mucoactive drugs, has been found exhibit antioxidant, anti-infective, anti-inflammatory in pre-clinical clinical reports. These properties have sparked interest potential treating lung diseases, including obstructive pulmonary disease (COPD), bronchiectasis (BE), cystic fibrosis (CF), idiopathic (IPF), which are oxidative stress, increased levels glutathione inflammation. NAC's noteworthy, it not solely secondary antioxidant capabilities. In ex vivo models COPD exacerbation, effects observed even at very low doses, especially prolonged treatment. The involves inhibition activation NF-kB neurokinin A production, resulting interleukin-6 cytokine abundantly present sputum breath condensate patients correlates number exacerbations. unique combination mucolytic, positions safe, cost-effective, efficacious therapy plethora conditions.

Language: Английский

Citations

10
GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway DOI Creative Commons

Xiaolin Sun,

Chaorui Guo, Chunyan Huang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 71, P. 103116 - 103116

Published: March 6, 2024

Oxidative stress plays an important role in the pathogenesis of acute lung injury (ALI). As a typical post-translational modification triggered by oxidative stress, protein S-glutathionylation (PSSG) is regulated redox signaling pathways and diverse roles conditions. In this study, we found that GSTP downregulation exacerbated LPS-induced human epithelial cells mice ALI models, confirming protective effect against both vitro vivo. Additionally, positive correlation was observed between total PSSG level expression tissues. Further results demonstrated inhibited KEAP1-NRF2 interaction promoting process KEAP1. By integration mass spectrometry, molecular docking, site-mutation validation assays, identified C434 KEAP1 as key site catalyzed GSTP, which promoted dissociation complex activated subsequent anti-oxidant genes. vivo experiments with AAV-GSTP confirmed inflammation activating NRF2 downstream antioxidant pathways. Collectively, study revealed novel regulatory mechanism anti-inflammatory function lungs modulating KEAP1/NRF2 pathway. Targeting at manipulation or activity might be promising therapeutic strategy for stress-induced progression.

Language: Английский

Citations

9
Citrus clementine Peel Essential Oil Ameliorates Potassium Dichromate-Induced Lung Injury: Insights into the PI3K/AKT Pathway DOI Creative Commons
Hany G. Attia,

Suzan M. El-Morshedy,

Ahmed M. Nagy

et al.

Metabolites, Journal Year: 2024, Volume and Issue: 14(1), P. 68 - 68

Published: Jan. 19, 2024

Acute Lung Injury (ALI) is a life-threatening syndrome that has been identified as potential complication of COVID-19. There critical need to shed light on the underlying mechanistic pathways and explore novel therapeutic strategies. This study aimed examine effects Citrus clementine essential oil (CCEO) in treating potassium dichromate (PDC)-induced ALI. The chemical profile CCEO was created through GC–MS analysis. An vivo rats conducted evaluate effect administrated via two different delivery systems (oral/inhalation) mitigating acute lung injury induced by intranasal instillation PDC. Eight volatile compounds were identified, with monoterpene hydrocarbons accounting for 97.03% constituents, including 88.84% D-limonene. at doses 100 200 mg/kg bw exhibited antioxidant anti-inflammatory properties. These significant properties revealed reduction malondialdehyde (MDA) restoration reduced glutathione (GSH). In addition, inflammation observed decreasing levels cytokines tumor necrosis factor-α growth factor-β (TNF-α TGF-β), along an increase phosphatidylinositide-3-kinase (PI3K) Akt overexpression tissue homogenate, both oral inhalation routes, compared PDC-induced group. results supported histopathological studies immunohistochemical assessment TGF-β tissues. findings plays integral role relieving ALI PDC suggests it promising remedy.

Language: Английский

Citations

8
Lipid-Laden Macrophages in Pulmonary Diseases DOI Creative Commons
Yin Zhu,

Dooyoung Choi,

Payaningal R. Somanath

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 889 - 889

Published: May 22, 2024

Pulmonary surfactants play a crucial role in managing lung lipid metabolism, and dysregulation of this process is evident various diseases. Alternations metabolism lead to pulmonary surfactant damage, resulting hyperlipidemia response injury. Lung macrophages are responsible for recycling damaged droplets maintain homeostasis. The inflammatory triggered by external stimuli such as cigarette smoke, bleomycin, bacteria can interfere with process, the formation lipid-laden (LLMs), also known foamy macrophages. Recent studies have highlighted potential significance LLM range Furthermore, growing evidence suggests that LLMs present patients suffering from conditions. In review, we summarize essential metabolic signaling pathways driving chronic obstructive disease, fibrosis, tuberculosis, acute

Language: Английский

Citations

8
Brain Oxygenation During Exercise in Different Types of Chronic Lung Disease: A Narrative Review DOI Creative Commons
Stella Kritikou, Andreas Zafeiridis, Georgia Pitsiou

et al.

Sports, Journal Year: 2025, Volume and Issue: 13(1), P. 9 - 9

Published: Jan. 8, 2025

Chronic lung diseases such as Obstructive Pulmonary Disease, Interstitial Lung Disease (ILD), and Hypertension (PH) are characterized by progressive symptoms dyspnea, fatigue, muscle weakness, often leading to physical inactivity, reduced quality of life. Many patients also experience significantly impaired exercise tolerance. While pulmonary, cardiovascular, respiratory, peripheral dysfunction contribute limitations, recent evidence suggests that hypoxia impairments in cerebral oxygenation may play a role intolerance. This narrative review (i) summarizes studies investigating responses during with different types chronic (ii) discusses possible mechanisms behind the blunted reported many these conditions; however, extent desaturation intensity at which it occurs can vary. These differences depend on specific pathophysiology disease presence comorbidities. Notably, fibrotic-ILD has been linked development dyspnea early termination. Understanding effects improve our understanding intolerance help identify therapeutic strategies enhance brain health capacity patients.

Language: Английский

Citations

1