Accumulation potential and tolerance response of Typha latifolia L. under citric acid assisted phytoextraction of lead and mercury

Chemosphere, Journal Year: 2020, Volume and Issue: 257, P. 127247 - 127247

Published: June 3, 2020

Language: Английский

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Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

Chemosphere, Journal Year: 2021, Volume and Issue: 285, P. 131213 - 131213

Published: July 7, 2021

Language: Английский

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Contaminant Exposure and Transport from Three Potential Reuse Waters within a Single Watershed

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(3), P. 1353 - 1365

Published: Jan. 10, 2023

Global demand for safe and sustainable water supplies necessitates a better understanding of contaminant exposures in potential reuse waters. In this study, we compared load contributions to surface from the discharge three waters (wastewater effluent, urban stormwater, agricultural runoff). Results document substantial varying organic-chemical contribution effluent discharges (e.g., disinfection byproducts [DBP], prescription pharmaceuticals, industrial/household chemicals), stormwater polycyclic aromatic hydrocarbons, pesticides, nonprescription pharmaceuticals), runoff pesticides). Excluding DBPs, episodic storm-event organic concentrations loads were comparable often exceeded those daily wastewater-effluent discharges. We also assessed if irrigation corn resulted measurable effects on rain-induced harvested feedstock. Overall, target-organic 491 g study field during 2019 growing season did not produce dissolved organic-contaminant subsequent events. Out 140 detected organics source irrigation, only imidacloprid estrone had that observable differences between effluent-irrigated nonirrigated fields. Analyses pharmaceuticals per-/polyfluoroalkyl substances at-harvest corn-plant samples two antibiotics, norfloxacin ciprofloxacin, at 36 70 ng/g, respectively, samples; no contaminants noneffluent irrigated samples.

Language: Английский

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Regulation of intracellular process by two-component systems: Exploring the mechanism of plasmid-mediated conjugative transfer

Water Research, Journal Year: 2024, Volume and Issue: 259, P. 121855 - 121855

Published: May 31, 2024

Language: Английский

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Recent progress in green and biopolymer based photocatalysts for the abatement of aquatic pollutants

Environmental Research, Journal Year: 2021, Volume and Issue: 199, P. 111324 - 111324

Published: May 12, 2021

Language: Английский

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Oxidative stress as a potential mechanism by which guanylurea disrupts the embryogenesis of Danio rerio

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 799, P. 149432 - 149432

Published: Aug. 3, 2021

Language: Английский

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The impact of pharmaceutical pollutants on daphnids – A metabolomic approach

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 100, P. 104157 - 104157

Published: May 22, 2023

Pharmaceuticals have been classified as emerging contaminants in the aquatic ecosystem, mainly due to their increased use and improper disposal. A significant range of pharmaceutical compounds metabolites globally detected surface waters pose detrimental effects non-target organisms. Monitoring water pollution relies on analytical approaches for detection, however, such are limited by sensitivity limit coverage wide compounds. This lack realism risk assessment is bypassed with effect-based methods, which complemented chemical screening impact modelling, able provide mechanistic insight pollution. Focusing freshwater this study we evaluated acute daphnids three distinct groups pharmaceuticals; antibiotics, estrogens, a commonly encountered environmentally relevant pollutants. Combining several endpoints mortality, biochemical (enzyme activities) holistic (metabolomics) discovered patterns biological responses. In study, changes enzymes metabolism e.g. phosphatases lipase, well detoxification enzyme, glutathione-S-transferase, were recorded following exposure selected pharmaceuticals. targeted analysis hydrophilic profile revealed up-regulation metformin, gabapentin, amoxicillin, trimethoprim β-estradiol. Whereas gemfibrozil, sulfamethoxazole oestrone resulted down-regulation majority metabolites.

Language: Английский

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Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family

The Journal of General Physiology, Journal Year: 2024, Volume and Issue: 156(3)

Published: Jan. 31, 2024

Proteins from the small multidrug resistance (SMR) family are frequently associated with horizontally transferred gene arrays found in bacteria wastewater and human-adjacent biosphere. Recent studies suggest that a subset of SMR transporters might participate metabolism common pharmaceutical metformin by bacterial consortia. Here, we show both genomic plasmid-associated SMRGdx functional subtype export byproducts microbial metabolism, particularly high efficiency for guanylurea. We use solid-supported membrane electrophysiology to evaluate transport kinetics guanylurea native substrate guanidinium four representative homologs. Using an internal reference normalize independent experiments, rates comparable homologs, using proteoliposome-based assay, 2 proton:1 stoichiometry is maintained. Additional characterization properties focuses on structurally characterized homolog, Gdx-Clo, which examined pH dependence thermodynamics binding solved x-ray crystal structure bound. Together, these experiments contribute two main ways. By providing first detailed kinetic examination homolog they provide framework will inform future mechanistic this model protein. Second, study casts light potential role handling its metabolic byproducts, insight into how physiologies co-opted contend new selective pressures.

Language: Английский

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Chronic exposure to environmentally relevant concentrations of guanylurea induces neurotoxicity of Danio rerio adults

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 819, P. 153095 - 153095

Published: Jan. 14, 2022

Language: Английский

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Chronic exposure to realistic concentrations of metformin prompts a neurotoxic response in Danio rerio adults

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 849, P. 157888 - 157888

Published: Aug. 9, 2022

Language: Английский

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