Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 209, P. 106356 - 106356
Published: Feb. 25, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9366 - 9366
Published: Aug. 29, 2024
The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.
Language: Английский
Citations
23
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137296 - 137296
Published: Jan. 19, 2025
Language: Английский
Citations
3
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 24, 2023
Inflammatory bowel disease (IBD) is becoming increasingly prevalent with the improvement of people's living standards in recent years, especially urban areas. The emerging environmental contaminant a newly-proposed concept progress industrialization and modernization, referring to synthetic chemicals that were not noticed or researched before, which may lead many chronic diseases, including IBD. contaminants mainly include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, persisting organic pollutants. In this review, we summarize adverse health effect these on humans their relationships Therefore, can better understand impact new IBD, minimize exposures, lower future incidence
Language: Английский
Citations
32
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13487 - 13487
Published: Aug. 30, 2023
Polybrominated diphenyl ethers (PBDEs) are a group of flame retardants used in plastics, textiles, polyurethane foam, and other materials. They contain two halogenated aromatic rings bonded by an ester bond classified according to the number position bromine atoms. Due their widespread use, PBDEs have been detected soil, air, water, dust, animal tissues. Besides, found various tissues, including liver, kidney, adipose, brain, breast milk plasma. The continued accumulation has raised concerns about potential toxicity, hepatotoxicity, kidney gut thyroid embryotoxicity, reproductive neurotoxicity, immunotoxicity. Previous studies suggested that there may be mechanisms contributing toxicity. present study aimed outline PBDEs' toxic effects on different organ systems. Given bioaccumulation adverse impacts human health living organisms, we summarize toxicity tend broaden horizons facilitate design new prevention strategies for PBDEs-induced
Language: Английский
Citations
26
Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133830 - 133830
Published: Feb. 22, 2024
The daunting effects of persistent organic pollutants on humans, animals, and the environment cannot be overemphasized. Their fate, persistence, long-range transport, bioavailability have made them an environmental stressor concern which has attracted interest research community. Concerted efforts been by relevant organizations utilizing legislative laws to ban their production get rid completely for sake public health. However, they remained refractive in different compartments environment. is majorly a function anthropogenic activities. Landfilling incineration are among earliest classical means remediation waste; however, not sustainable due seepage contaminants landfills, release toxic gases into atmosphere energy requirements during incineration. Other advanced waste destruction technologies explored degradation these recalcitrant pollutants; although, some efficient, but limited high amounts consumption, use solvents hazardous chemicals, capital operational cost, lack trust. Thus, this study systematically reviewed contaminant technologies, efficiency, feasibility. Finally, based techno-economic feasibility, non-invasiveness, friendliness; radiation technology can considered viable alternative all matrices at bench-, pilot-, industrial-scale.
Language: Английский
Citations
10
Medicina, Journal Year: 2023, Volume and Issue: 59(6), P. 1119 - 1119
Published: June 9, 2023
Alarming statistics show that the number of people affected by excessive weight has surpassed 2 billion, representing approximately 30% world's population. The aim this review is to provide a comprehensive overview one most serious public health problems, considering obesity requires an integrative approach takes into account its complex etiology, including genetic, environmental, and lifestyle factors. Only understanding connections between many contributors synergy treatment interventions can ensure satisfactory outcomes in reducing obesity. Mechanisms such as oxidative stress, chronic inflammation, dysbiosis play crucial role pathogenesis associated complications. Compounding factors deleterious effects novel challenge posed obesogenic digital (food) environment, stigma with should not be overlooked. Preclinical research animal models been instrumental elucidating these mechanisms, translation clinical practice provided promising therapeutic options, epigenetic approaches, pharmacotherapy, bariatric surgery. However, more studies are necessary discover new compounds target key metabolic pathways, innovative ways deliver drugs, optimal combinations allopathic treatments, and, last but least, emerging biological markers for effective monitoring. With each passing day, crisis tightens grip, threatening only individual lives also burdening healthcare systems societies at large. It high time we took action confront urgent imperative address escalating global head-on.
Language: Английский
Citations
22
Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 24(5), P. 839 - 870
Published: April 29, 2023
Obesity has reached epidemic proportion worldwide and in all ages. Available evidence points to a multifactorial pathogenesis involving gene predisposition environmental factors. Gut microbiota plays critical role as major interface between external factors, i.e., diet, lifestyle, toxic chemicals, internal mechanisms regulating energy metabolic homeostasis, fat production storage. A shift composition is linked with overweight obesity, pathogenic bacterial products metabolites (mainly endocannabinoid-related mediators, short-chain fatty acids, bile catabolites of tryptophan, lipopolysaccharides) subsequent alterations gut barrier, altered insulin resistance chronic, low-grade inflammation. Although animal studies point the links an "obesogenic" development different obesity phenotypes, translational value these results humans still limited by heterogeneity among studies, high variation over time lack robust longitudinal adequately considering inter-individual confounders. Nevertheless, available underscores existence several genera predisposing or, conversely, lean metabolically health phenotype (e.g., Akkermansia muciniphila, species from Faecalibacterium, Alistipes, Roseburia). Further using metagenomics, transcriptomics, proteomics, metabolomics exact characterization confounders are needed this field. Results must confirm that distinct specific microbial-derived represent effective precision interventions against long-term.
Language: Английский
Citations
20
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: May 10, 2024
Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.
Language: Английский
Citations
8
Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2333 - 2333
Published: Nov. 15, 2024
The human gut is a complex ecosystem that supports billions of living species, including bacteria, viruses, archaea, phages, fungi, and unicellular eukaryotes. Bacteria give genes enzymes for microbial host-produced compounds, establishing symbiotic link between the external environment host at both systemic levels. microbiome, which primarily made up commensal critical maintaining healthy host's immune system, aiding digestion, synthesizing essential nutrients, protecting against pathogenic as well influencing endocrine, neural, humoral, immunological functions metabolic pathways. Qualitative, quantitative, and/or topographic shifts can alter resulting in dysbiosis dysfunction, contribute to variety noncommunicable illnesses, hypertension, cardiovascular disease, obesity, diabetes, inflammatory bowel cancer, irritable syndrome. While most evidence date observational does not establish direct causation, ongoing clinical trials advanced genomic techniques are steadily enhancing our understanding these intricate interactions. This review will explore key aspects relationship microbiota, eubiosis, health highlighting emerging strategies microbiome engineering potential therapeutic approaches various conditions.
Language: Английский
Citations
8
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 20, 2024
The human gut microbiota is a complex microbial community with critical functions for the host, including transformation of various chemicals. While effects on microorganisms has been evaluated using single-species models, their functional within more communities remain unclear. In this study, we investigated response simplified model (SIHUMIx) cultivated in an vitro bioreactor system combination 96 deep-well plates after exposure to 90 different xenobiotics, comprising 54 plant protection products and 36 food additives dyes, at environmentally relevant concentrations. We employed metaproteomics metabolomics evaluate changes bacterial abundances, production Short Chain Fatty Acids (SCFAs), regulation metabolic pathways. Our findings unveiled significant induced by 23 out 28 across all three categories assessed. Notable highlights include azoxystrobin, fluroxypyr, ethoxyquin causing substantial reduction (log 2 FC < −0.5) concentrations primary SCFAs: acetate, butyrate, propionate. Several had relative abundances species; example, acid orange 7 saccharin led 75% decrease Clostridium butyricum , additional 2.5-fold increase E. coli compared control. Furthermore, both groups exhibited up- down-regulation pathways, those related metabolism amino acids such as histidine, valine, leucine, isoleucine, well secretion systems energy pathways like starch, sucrose, butanoate, pyruvate metabolism. This research introduces efficient technique that enables high-throughput screening structure function well-defined against chemicals metabolomics. believe approach will be instrumental characterizing chemical-microbiota interactions especially important regulatory chemical risk assessments.
Language: Английский
Citations
7