Cited by Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress DOI

Tiantian Guo,

Xiren Geng,

Yue Zhang

et al.

Poultry Science, Journal Year: 2024, Volume and Issue: 103(6), P. 103674 - 103674

Published: March 16, 2024

Microplastics biological toxicity, environmental persistence and chemicals have been paid widespread attention. exposed to chicken spleen injury of the specific mechanism is unclear. Thus, we randomly assigned chickens 4 groups: C (normal diet), L-MPs (1 mg/L), M-MPs (10 H-MPs (100 assessed damage after 42 d exposure. Morphologically, boundary between red white pulp was blurred, along with expansion pulp. It further speculated that microplastics induced mitochondrial dynamic homeostasis (Drp1 upgraded, Mfn1, Mfn2, OPA1 reduced), provoked apoptotic pathway (Bcl-2/Bax decreased, cytc, caspase3, caspase9 raised), resulting in redox imbalance lipid peroxide accumulation (MDA increased, CAT, GSH, T-AOC plummeted), stimulated ferroptosis (FTH1, GPX4, SLC7A11 decreased). Here explored impact polystyrene on spleen, as well programmed death (apoptosis ferroptosis) involved, regulative role mitochondria this process. This could be significant importance bridging gap laboratory research microplastics-induced chicken.

Language: Английский

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Selective bioaccumulation of polystyrene nanoplastics in fetal rat brain and damage to myelin development DOI

Yaping Zhang,

Lei Tian,

Jiang Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116393 - 116393

Published: May 6, 2024

Micro(nano)plastic, as a new type of environmental pollutant, have become potential threat to the life and health various stages biology. However, it is not yet clear whether they will affect brain development in fetal stage. Therefore, this study aims explore effects nanoplastics on rat brains. To assess allocation NPs (25 nm 50 nm) regions brain, pregnant rats were exposed concentrations (50, 10, 2.5, 0.5 mg/kg) PS-NPs. Our results provided evidence transplacental transfer PS-NPs with prominent presence observed several cerebral regions, notably cerebellum, hippocampus, striatum, prefrontal cortex. This distribution bias might be linked developmental sequence each region. Additionally, we explored influence prenatal exposure myelin given its highest PS-NP accumulation offspring. Compared control rats, caused significant reduction basic protein (MBP) oligodendrocyte glycoprotein (MOG) expression, decrease thickness, an increase cell apoptosis, decline population. These gave rise motor deficits. In conclusion, our identified specific following revealed that can suppress formation cerebellum fetus.

Language: Английский

Citations

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway DOI

Xiaodan Wang,

Jiatong Sun,

Tong Xu

et al.

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 39(4), P. 2052 - 2063

Published: Dec. 14, 2023

Abstract Imidacloprid (IMI) is a neonicotinoid insecticide with the highest global market share, and IMI exposure in environment can negatively affect many nontarget organisms (a general term for affected by drugs other than target organisms). Resveratrol (RSV), non‐flavonoid polyphenolic organic compound derived from peanuts, grapes, plants, has anti‐inflammatory antioxidant effects. It currently unclear how RSV protects against cell damage caused IMI. Therefore, we established an experimental model of chicken lymphocyte lines exposed to 110 μg/mL and/or 0.5 μM 24 h. According results, markedly raised intracellular reactive oxygen species levels diminished activity cellular enzymes (CAT, SOD, GPx), leading MDA accumulation decreased T‐AOC. JNK , ERK P38 essential components mitogen‐activated protein kinase (MAPK) signaling pathway, were also expressed more when was present. Additionally, resulted upregulation mitochondrial apoptosis ( Caspase 3 9 Bax Cyt‐c ) necroptosis 8 RIPK1 RIPK3 MLKL related factors expression, downregulation Bcl‐2 induction cytokine IL‐6 TNF‐α IFN‐γ expression. The combined treatment significantly reduced oxidative stress levels, inhibited MAPK alleviated IMI‐induced apoptosis, necroptosis, immune dysfunction. To summarize, antagonized dysfunction inhibiting ROS/MAPK pathway.

Language: Английский

Citations

Induction of autophagy via the ROS-dependent AMPK/mTOR pathway protects deoxynivalenol exposure grass carp hepatocytes damage DOI

Xin Chen, Jun Ma, Hao Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 135, P. 108687 - 108687

Published: March 13, 2023

Language: Английский

Citations

Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway DOI

Lihui Xuan, Yin Wang,

Can Qu

et al.

Chemosphere, Journal Year: 2023, Volume and Issue: 342, P. 140108 - 140108

Published: Sept. 13, 2023

Language: Английский

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