Neurotoxicity and accumulation of CPPD quinone at environmentally relevant concentrations in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 361, P. 142499 - 142499

Published: May 31, 2024

Language: Английский

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Tissue Accumulation and Biotransformation of 6PPD-Quinone in Adult Zebrafish and Its Effects on the Intestinal Microbial Community

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(23), P. 10275 - 10286

Published: June 3, 2024

The pronounced lethality of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPD-quinone or 6PPDQ) toward specific salmonids, while sparing other fish species, has received considerable attention. However, the underlying cause this species-specific toxicity remains unresolved. This study explored 6PPDQ toxicokinetics and intestinal microbiota composition in adult zebrafish during a 14-day exposure to environmentally realistic concentrations, followed by 7-day recovery phase. Predominant accumulation occurred brain, intestine, eyes, with lowest levels liver. Six metabolites were found undergo hydroxylation, two additionally undergoing O-sulfonation. Semiquantitative analyses revealed that predominant metabolite featured hydroxy group situated on phenyl ring adjacent quinone. was further validated assessing enzyme activity determining silico binding interactions. Notably, affinity between phase I II enzymes exceeded corresponding coho salmon 1.04–1.53 times, suggesting higher potential for detoxification tolerant species. Whole-genome sequencing significant increases genera Nocardioides Rhodococcus after 6PPDQ. Functional annotation pathway enrichment predicted these would be responsible biodegradation metabolism xenobiotics. These findings offer crucial data comprehending 6PPDQ-induced toxicity.

Language: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175057 - 175057

Published: July 26, 2024

Language: Английский

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Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(48), P. 19295 - 19303

Published: Nov. 8, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common additives used in rubber, enters environment due to significant emissions tire wear particles. 6-PPD quinone (6-PPDQ) is an important derivative after ozonization. With concentrations ranging from nanograms per liter μg/L, 6-PPDQ has so far been identified a series water samples. Acute lethality coho salmon (LC50 < 1 μg/L) was lower than environmental 6-PPDQ, highlighting exposure risks 6-PPDQ. It becoming increasingly necessary investigate potential toxicity at concentrations. Here, we examined effect on lifespan and healthspan underlying mechanism Caenorhabditis elegans. Exposure (1 10 shortened lifespan. Meanwhile, during aging process, (0.1–10 could decrease both pumping rate locomotion behavior, suggesting healthspan. For molecular mechanism, dysregulation insulin signaling pathway linked In pathway, DAF-2 restricted function DAF-16 activate downstream targets (SOD-3 HSP-6), which turn controlled Additionally, response toxicity, peptides (INS-6, INS-7, DAF-28) corresponding receptor DAF-2. Therefore, environmentally relevant potentially causes damage by activating organisms.

Language: Английский

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Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans

Environmental Pollution, Journal Year: 2023, Volume and Issue: 337, P. 122649 - 122649

Published: Sept. 28, 2023

Language: Английский

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A mini review on 6PPD quinone: A new threat to aquaculture and fisheries

Environmental Pollution, Journal Year: 2023, Volume and Issue: 340, P. 122828 - 122828

Published: Oct. 29, 2023

Language: Английский

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Stable isotope-assisted mass spectrometry reveals in vivo distribution, metabolism, and excretion of tire rubber-derived 6PPD-quinone in mice

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169291 - 169291

Published: Dec. 15, 2023

Language: Английский

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Long-term exposure to 6-PPD quinone at environmentally relevant concentrations causes neurotoxicity by affecting dopaminergic, serotonergic, glutamatergic, and GABAergic neuronal systems in Caenorhabditis elegans

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171291 - 171291

Published: Feb. 27, 2024

Language: Английский

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Mixture toxicity of 6PPD-quinone and polystyrene nanoplastics in zebrafish

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123835 - 123835

Published: March 21, 2024

Plastic pollution, including micro- and nanoplastics, is a growing concern. Tyre-wear particles (TWPs) are the second largest source of microplastics in ocean following abrasion synthetic fibres. In addition to themselves, TWPs contain many harmful chemicals, 6PPD. This chemical reacts with atmospheric ozone forms toxic compound 6PPD-quinone (6PPDq), which poses danger aquatic life. There knowledge gap understanding risks associated combined toxicity nanoplastics (NPs) 6PPDq. The present study aimed investigate NPs 6PPDq on adult zebrafish using phenotypic (behaviour, histology) transcriptomic endpoints. Zebrafish were exposed four treatments: control (contaminant-free), 50 μg/L 6PPDq, 3 mg/L polystyrene (PS)-NPs, combination PS-NPs. We did not observe locomotory dysregulation NPs. However, we found significant hyperlocomotion this effect was even more substantial after co-exposure explores molecular mechanisms behind these effects, identifying genes neurotransmitters fatty acid metabolism that dysregulated by co-exposure. Transcriptomic analysis further showed both PS-NPs impacted cellular processes sterol biosynthesis, cholesterol metabolism, muscle tissue development. effects stronger co-exposed zebrafish, indicating heightened risk integrity mitochondrial dysfunction. These results highlight significance mixture when studying chemicals like

Language: Английский

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P-phenylenediamine antioxidants and their quinone derivatives: A review of their environmental occurrence, accessibility, potential toxicity, and human exposure

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174449 - 174449

Published: July 3, 2024

Language: Английский

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