Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Antioxidants, Journal Year: 2021, Volume and Issue: 11(1), P. 20 - 20

Published: Dec. 22, 2021

The prominent cultivation of lemongrass (Cymbopogon spp.) relies on the pharmacological incentives its essential oil. Lemongrass oil (LEO) carries a significant amount numerous bioactive compounds, such as citral (mixture geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, elemol, in addition to other compounds. These components confer various actions LEO, including antifungal, antibacterial, antiviral, anticancer, antioxidant properties. LEO attributes are commercially exploited pharmaceutical, cosmetics, food preservations industries. Furthermore, application treatment cancer opens new vista field therapeutics. Although different have shown promising anticancer activities vitro, their effects not yet been assessed human system. Hence, further studies mechanisms conferred by required. present review intends provide timely discussion relevance combating sustaining healthcare, well industry applications.

Language: Английский

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The Role of Chronic Inflammation in Pediatric Cancer

Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 154 - 154

Published: Jan. 6, 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.

Language: Английский

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RNA-based therapies: A cog in the wheel of lung cancer defense

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: March 19, 2021

Abstract Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small cell lung (NSCLC) and small (SCLC), remains the leading cause death worldwide. Despite recent advances in therapies, overall 5-year survival rate LC less than 20%. The efficacy current therapeutic approaches compromised by inherent or acquired drug-resistance severe off-target effects. Therefore, identification development innovative effective are critically desired for LC. RNA-mediated gene inhibition technologies was turning point field RNA biology. critical regulatory role different RNAs multiple pathways makes them rich source targets tools developing anticancer therapies. antisense sequences, short interfering (siRNAs), microRNAs (miRNAs miRs), anti-miRs, mRNA-based platforms holds great promise preclinical early clinical evaluation against In last decade, RNA-based therapies have substantially expanded tested trials malignancies, including This article describes understanding various aspects therapeutics, modern platforms, modifications, combinations with chemo-/immunotherapies that translational potential

Language: Английский

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Emerging delivery approaches for targeted pulmonary fibrosis treatment

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 204, P. 115147 - 115147

Published: Dec. 6, 2023

Language: Английский

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An Overview of Current Detection Methods for RNA Methylation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3098 - 3098

Published: March 7, 2024

Epitranscriptomic mechanisms, which constitute an important layer in post-transcriptional gene regulation, are involved numerous cellular processes under health and disease such as stem cell development or cancer. Among various RNA methylation is considered to have vital roles eukaryotes primarily due its dynamic reversible nature. There methylations that include, but not limited to, 2'-O-dimethyladenosine (m6Am), N7-methylguanosine (m7G), N6-methyladenosine (m6A) N1-methyladenosine (m1A). These biochemical modifications modulate the fate of by affecting translation, target site determination, processing, polyadenylation, splicing, structure, editing stability. Thus, it highly quantitatively measure changes marks gain insight into disease. Although there complicating challenges identifying certain genome wide, methods been developed recently facilitate quantitative measurement methylated RNAs. To this end, detection for can be classified five categories antibody-based, digestion-based, ligation-based, hybridization-based direct RNA-based methods. In review, we aimed summarize our current understanding methylation, highlighting their advantages disadvantages, along with field.

Language: Английский

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Methylomics and cancer: the current state of methylation profiling and marker development for clinical care

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Oct. 16, 2023

Abstract Epigenetic modifications have long been recognized as an essential level in transcriptional regulation linking behavior and environmental conditions or stimuli with biological processes disease development. Among them, methylation is the most abundant of these reversible epigenetic marks, predominantly occurring on DNA, RNA, histones. Methylation modification intimately involved regulating gene transcription cell differentiation, while aberrant status has linked cancer development several malignancies. Early detection precise restoration dysregulated form basis for epigenetics-based therapeutic strategies. In this review, we summarize current basic understanding mechanisms responsible cover cutting-edge research techniques detecting across genome transcriptome. We then explore recent advances clinical diagnostic applications markers various cancers address state future prospects therapies different diseases, especially comparing pharmacological methylase/demethylase inhibitors CRISPRoff/on editing systems. This review thus provides a resource emerging role cancer, use methylation-based biomarkers detection, novel methylation-targeted drugs.

Language: Английский

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Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Published: June 21, 2021

The prominent cultivation of lemongrass relies on the pharmacological incentives its essential oil. oil (LEO) has a significant amount citral (mixture geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, elemol in addition to numerous other bioactive compounds. These components confer various medicinal activities LEO including antifungal, antibacterial, antiviral, anticancer, antioxidant properties. attributes are commercially exploited pharmaceutical, cosmetics, food preservations industries. Furthermore, employment treatment cancer opens new vista field therapeutics. Although different have shown promising anticancer vitro, these effects not been assessed yet humans. Further studies mechanisms exerted by required. present review intends provide timely discussion relevance extracts health treatment, industry applications.

Language: Английский

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Identification and Verification of m7G Modification Patterns and Characterization of Tumor Microenvironment Infiltration via Multi-Omics Analysis in Clear Cell Renal Cell Carcinoma

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: May 3, 2022

The epigenetic modification of tumorigenesis and progression in neoplasm has been demonstrated recent studies. Nevertheless, the underlying association N7-methylguanosine (m7G) regulation with molecular heterogeneity tumor microenvironment (TME) clear cell renal carcinoma (ccRCC) remains unknown. We explored expression profiles genetic variation features m7G regulators identified their correlations patient outcomes pan-cancer. Three distinct patterns, including MGCS1, MGCS2, MGCS3, were further determined systematically characterized via multi-omics data ccRCC. Compared other two subtypes, patients MGCS3 exhibited a lower clinical stage/grade better prognosis. MGCS1 showed lowest enrichment metabolic activities. MGCS2 was by suppression immunity. then established validated scoring tool named m7Sig, which could predict prognosis ccRCC patients. This study revealed that played vital role formation Evaluating landscape helps us to raise awareness strengthen understanding ccRCC's characterization and, furthermore, guide future decision making.

Language: Английский

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Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 396 - 396

Published: Jan. 30, 2024

Cancer etiology involves complex interactions between genetic and non-genetic factors, with epigenetic mechanisms serving as key regulators at multiple stages of pathogenesis. Poor dietary habits contribute to cancer predisposition by impacting DNA methylation patterns, non-coding RNA expression, histone landscapes. Histone post-translational modifications (PTMs), including acyl marks, act a molecular code play crucial role in translating changes cellular metabolism into enduring patterns gene expression. As cells undergo metabolic reprogramming support rapid growth proliferation, nuanced roles have emerged for dietary- metabolism-derived acylation progression. Specific types acylation, beyond the standard acetylation shed light on how metabolites reshape gut microbiome, influencing dynamics repertoires. Given reversible nature PTMs, corresponding readers, writers, erasers are discussed this review context prevention treatment. The evolving ‘acyl code’ provides improved biomarker assessment clinical validation diagnosis prognosis.

Language: Английский

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Advances in nano drug delivery systems for enhanced efficacy of emodin in cancer therapy

International Journal of Pharmaceutics X, Journal Year: 2024, Volume and Issue: 9, P. 100314 - 100314

Published: Dec. 25, 2024

Cancer remains one of the leading causes death worldwide, highlighting urgent need for novel antitumor drugs. Natural products have long been a crucial source anticancer agents. Among these, emodin (EMO), multifunctional anthraquinone compound, exhibits significant effects but is hindered in clinical applications by challenges such as low solubility, rapid metabolism, poor bioavailability, and off-target toxicity. Nano drug delivery systems offer effective strategies to overcome these limitations enhancing stability, targeting ability EMO. While substantial progress has made developing EMO-loaded nanoformulations, comprehensive review on this topic still lacking. This paper aims fill gap providing an overview recent advancements nanocarriers EMO their applications. These carriers include liposomes, nanoparticles, polymeric micelles, nanogels, others, with nanoparticle-based formulations being most extensively explored. Nanoformulations encapsulating demonstrated promising therapeutic results against various cancers, particularly breast cancer, followed liver lung cancers. We systematically summarize preparation methods, materials, physicochemical properties nanopreparations, underscoring key findings how nanotechnology improves efficacy provides valuable insights researchers engaged nano

Language: Английский

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