Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer DOI Creative Commons

Wei Tan,

Fangfang Dai,

Qinyu Ci

et al.

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 24, 2025

Cuproptosis is a novel form of cell death, acting on the tricarboxylic acid cycle in mitochondrial respiration and mediated by protein lipoylation. Other cancer death processes, such as necroptosis, pyroptosis, ferroptosis, have been shown to play crucial roles therapy prognosis ovarian cancer. However, role cuproptosis remains unclear. The expression profiles 10 cuproptosis-related genes were extracted from GSE140082. Kaplan-Meier survival Cox proportional hazards regression used identify prognostic for constructing risk models. Following this, Least Absolute Shrinkage Selection Operator was employed construct score model. Next, nomogram constructed predict overall Ultimately, our analysis compared two groups across various dimensions, including clinical characteristics, tumor progression, metabolism-related pathways, immune landscape, drug sensitivity. MTF1 LIAS identified protective factors cancer, with patients higher group being significantly associated poorer survival. Furthermore, integrating characteristics demonstrated high specificity sensitivity predicting A propotion M2 macrophages, follicular helper T cells, resting mast cells observed high-risk group. Additionally, IC50 values Dasatinib, Bortezomib, Parthenolide, Imatinib lower study highlights significance provides new insights into developing pharmacological therapeutic strategies targeting prevention treatment

Language: Английский

Unveiling the mechanisms and challenges of cancer drug resistance DOI Creative Commons
Sameer Ullah Khan, Kaneez Fatima,

Shariqa Aisha

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 12, 2024

Abstract Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer strategies are evolving due to innate acquired capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells survive progress under unfavorable conditions. Although the mechanism of drug being widely studied generate new target-based drugs with better potency than existing ones. However, broader flexibility in resistance, advanced therapeutic options efficacy need be explored. Combination therapy an alternative a success rate though risk amplified side effects commonplace. Moreover, recent groundbreaking precision immune ways overcome has revolutionized anticancer greater extent only limitation individual-specific needs further attention. This review will focus on challenges opted withstand current therapies at molecular level also highlights emerging -like immunological, stem cell-based may prove have potential challenge problem resistance.

Language: Английский

Citations

91
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies DOI
Xidi Wang, Miao Zhou, Yu Liu

et al.

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216157 - 216157

Published: April 1, 2023

Language: Английский

Citations

77
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis DOI Creative Commons

Shimeng Zhou,

Junlan Liu, Andi Wan

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 23, 2024

Abstract Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action various physical, chemical and biological factors. The exploration tumorigenesis mechanism crucial for early prevention treatment tumors. Epigenetic modification common important in cells, including DNA methylation, histone modification, non-coding RNA m6A modification. mode cell death programmed by death-related genes; however, recent researches have revealed some new modes death, pyroptosis, ferroptosis, cuproptosis disulfidptosis. regulation deaths mainly involved key proteins affects up-regulating or down-regulating expression levels proteins. This study aims to investigate epigenetic modifications regulating disulfidptosis tumor explore possible triggering factors development microscopic point view, provide potential targets therapy perspective antitumor drugs combination therapies.

Language: Английский

Citations

31
Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes DOI Creative Commons
Na Chen, Lizhe Guo, Lu Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 7, 2024

Abstract Sleep disorders increase the risk and mortality of heart disease, but brain-heart interaction has not yet been fully elucidated. Cuproptosis is a copper-dependent type cell death activated by excessive accumulation intracellular copper. Here, we showed that 16 weeks sleep fragmentation (SF) resulted in elevated copper levels male mouse exacerbated myocardial ischemia–reperfusion injury with increased cuproptosis apoptosis. Mechanistically, found SF promotes sympathetic overactivity, increases germination nerve terminals, level norepinephrine cardiac tissue, thereby inhibits VPS35 expression leads to impaired ATP7A related transport overload cardiomyocytes. Copper further apoptosis, these effects can be rescued excision or administration chelating agent. Our study elucidates one molecular mechanisms which aggravate suggests possible targets for intervention.

Language: Английский

Citations

22
Copper in colorectal cancer: From copper‐related mechanisms to clinical cancer therapies DOI Creative Commons
Yuhong Wang, Pei Pei, Kai Yang

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(6)

Published: May 28, 2024

Abstract Copper, a trace element and vital cofactor, plays crucial role in the maintenance of biological functions. Recent evidence has established significant correlations between copper levels, cancer development metastasis. The strong redox‐active properties offer both benefits disadvantages to cells. intestinal tract, which is primarily responsible for uptake regulation, may suffer from an imbalance homeostasis. Colorectal (CRC) most prevalent primary tract aggressive malignant disease with limited therapeutic options. Current research focused on relationship CRC. Innovative concepts, such as cuproplasia cuproptosis, are being explored understand copper‐related cellular proliferation death. Cuproplasia regulation cell that mediated by enzymatic nonenzymatic copper‐modulated activities. Whereas, cuproptosis refers death induced excess via promoting abnormal oligomerisation lipoylated proteins within tricarboxylic acid cycle, well diminishing levels iron‐sulphur cluster proteins. A comprehensive understanding mechanisms offers new avenues CRC treatment. In this review, we summarise evolving molecular mechanisms, ranging intracellular concentrations discovered, discuss pathogenesis, progression potential therapies Understanding will help provide theoretical foundation innovative treatment strategies management.

Language: Английский

Citations

20
The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy DOI Creative Commons
Zhen Tang, Hui Dong, Tian Li

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2021, Volume and Issue: 2021(1)

Published: Jan. 1, 2021

Increasing evidence suggests that traditional Chinese medicine strategies are obviously beneficial for cancer treatment, but scientific research on the underlying molecular mechanisms is lacking. We report ursolic acid, a bioactive ingredient isolated from Radix Actinidiae chinensis, has strong antitumour effects osteosarcoma cells. Functional studies showed acid inhibited tumour cell proliferation and promoted apoptosis of variety Ursolic had synergistic cytotoxic effect with cisplatin In mouse xenograft model, low-dose combined significantly reduced growth. Notably, reversed weight loss in mice treated cisplatin. Mechanistic degraded ferritin by activating autophagy induced intracellular overload ferrous ions, leading to ferroptosis. addition, enhanced DNA-damaging Taken together, these findings suggest nontoxic adjuvant may enhance effectiveness chemotherapy osteosarcoma.

Language: Английский

Citations

59
Golgi Metal Ion Homeostasis in Human Health and Diseases DOI Creative Commons
Jie Li, Yanzhuang Wang

Cells, Journal Year: 2022, Volume and Issue: 11(2), P. 289 - 289

Published: Jan. 15, 2022

The Golgi apparatus is a membrane organelle located in the center of protein processing and trafficking pathway. It consists sub-compartments with distinct biochemical compositions functions. Main functions Golgi, including trafficking, glycosylation, sorting, require well-maintained stable microenvironment along metal ion homeostasis. Metal ions, such as Ca2+, Mn2+, Zn2+, Cu2+, are important cofactors many resident glycosylation enzymes. homeostasis ions secretory pathway, which required for proper function stress response tightly regulated maintained by transporters. Mutations transporters cause human diseases. Here we provide review specifically focusing on that maintain under physiological conditions their alterations

Language: Английский

Citations

38
Structures of the human Wilson disease copper transporter ATP7B DOI Creative Commons
Guo-Min Yang, Lingyi Xu, Rou‐Min Wang

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(5), P. 112417 - 112417

Published: April 18, 2023

The P-type ATPase ATP7B exports cytosolic copper and plays an essential role in the regulation of cellular homeostasis. Mutants cause Wilson disease (WD), autosomal recessive disorder metabolism. Here, we present cryoelectron microscopy (cryo-EM) structures human E1 state apo, putative copper-bound, cisplatin-bound forms. In ATP7B, N-terminal sixth metal-binding domain (MBD6) binds at entry site transmembrane (TMD), facilitating delivery from MBD6 to TMD. sulfur-containing residues TMD mark transport pathway. By comparing E2-Pi frog propose ATP-driving model ATP7B. These not only advance our understanding mechanisms ATP7B-mediated export but can also guide development therapeutics for treatment WD.

Language: Английский

Citations

29
Cuproptosis and cuproptosis-related genes: Emerging potential therapeutic targets in breast cancer DOI
Xiangdong Liu, Bo Luo, Xinhong Wu

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189013 - 189013

Published: Oct. 31, 2023

Language: Английский

Citations

28
Melodic maestros: Unraveling the role of miRNAs in the diagnosis, progression, and drug resistance of malignant pleural mesothelioma DOI

Mai A. Abd‐Elmawla,

Sherif S. Abdel Mageed, Tohada M. AL‐Noshokaty

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 250, P. 154817 - 154817

Published: Sept. 13, 2023

Language: Английский

Citations

24