Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Nov. 1, 2022
Colorectal
cancer
(CRC)
is
the
third
most
common
and
second
leading
cause
of
cancer-related
death
worldwide.
Countless
CRC
patients
undergo
disease
progression.
As
a
hallmark
cancer,
Warburg
effect
promotes
metastasis
remodels
tumor
microenvironment,
including
promoting
angiogenesis,
immune
suppression,
cancer-associated
fibroblasts
formation
drug
resistance.
Targeting
metabolism
would
be
promising
method
for
treatment
CRC.
In
this
review,
we
summarize
information
about
roles
in
microenvironment
to
elucidate
mechanisms
governing
identify
novel
targets
therapy.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5607 - 5651
Published: Jan. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1774 - 1808
Published: Jan. 1, 2023
Metabolic
reprogramming
is
one
of
the
most
important
hallmarks
malignant
tumors.Specifically,
lipid
metabolic
has
marked
impacts
on
cancer
progression
and
therapeutic
response
by
remodeling
tumor
microenvironment
(TME).In
past
few
decades,
immunotherapy
revolutionized
treatment
landscape
for
advanced
cancers.Lipid
plays
pivotal
role
in
regulating
immune
to
immunotherapy.Here,
we
systematically
reviewed
characteristics,
mechanism,
cells
TME,
appraised
effects
various
cell
death
modes
(specifically
ferroptosis)
metabolism,
summarized
antitumor
therapies
targeting
metabolism.Overall,
profound
microenvironment;
therefore,
may
lead
development
innovative
clinical
applications
including
sensitizing
immunotherapy.
Cancers,
Journal Year:
2022,
Volume and Issue:
14(14), P. 3297 - 3297
Published: July 6, 2022
Carbonic
Anhydrase
IX
(CAIX)
is
a
major
metabolic
effector
of
tumor
hypoxia
and
regulates
intra-
extracellular
pH
acidosis.
Significant
advances
have
been
made
recently
in
the
development
therapeutic
targeting
CAIX.
These
approaches
include
antibody-based
immunotherapy,
as
well
use
antibodies
to
deliver
toxic
radioactive
payloads.
In
addition,
large
number
small
molecule
inhibitors
which
inhibit
enzymatic
activity
CAIX
described.
this
commentary,
we
highlight
current
status
strategies
both
pre-clinical
clinical
space,
discuss
future
perspectives
that
leverage
inhibition
combination
with
additional
targeted
therapies
enable
effective,
durable
for
cancer
therapy.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 24, 2024
Abstract
Currently
three
major
problems
seriously
limit
the
practical
application
of
cancer
photodynamic
therapy
(PDT):
(i)
hypoxic
tumor
microenvironment
(TME);
(ii)
low
generation
efficiency
toxic
reactive
oxygen
species
(ROS)
in
aggregates
and
(iii)
shallow
tissue
penetration
depth
excitation
light.
Very
limited
approaches
are
available
for
addressing
all
above
with
a
single
design.
Herein,
rational
“three
birds
one
stone”
molecular
nanoengineering
strategy
is
demonstrated:
nanoplatform
U‐Ir@PAA‐ABS
based
on
covalent
combination
lanthanide‐doped
upconversion
nanoparticles
(UCNPs)
an
AIE‐active
dinuclear
Ir(III)
complex
provides
concentration‐dependent
type‐I
photochemical
process
upon
980
nm
irradiation
by
Föster
resonance
energy
transfer
(FRET).
targets
mitochondria
has
excellent
phototoxicity
even
severe
hypoxia
environments
irradiation,
inducing
dual‐mode
cell
death
mechanism
apoptosis
ferroptosis.
Taken
together,
vitro
vivo
results
demonstrate
successful
improving
efficacy
PDT
against
tumors.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
202, P. 107128 - 107128
Published: March 2, 2024
The
damage
of
integrated
epithelial
epithelium
is
a
key
pathogenic
factor
and
closely
associated
with
the
recurrence
ulcerative
colitis
(UC).
Here,
we
reported
that
vanillic
acid
(VA)
exerted
potent
therapeutic
effects
on
DSS-induced
by
restoring
intestinal
homeostasis
via
inhibition
ferroptosis.
By
CETSA
assay
DARTS
assay,
identified
carbonic
anhydrase
IX
(CAIX,
CA9)
as
direct
target
VA.
binding
VA
to
CA9
causes
insulin-induced
gene-2
(INSIG2)
interact
stromal
interaction
molecule
1
(STIM1),
rather
than
SREBP
cleavage-activating
protein
(SCAP),
leading
translocation
SCAP-SREBP1
from
endoplasmic
reticulum
(ER)
Golgi
apparatus
for
cleavage
into
mature
SREBP1.
activation
SREBP1
induced
then
significantly
facilitated
transcription
SCD1
exert
an
inhibitory
effect
inhibiting
excessive
death
cells
caused
ferroptosis,
effectively
preserved
integrity
barrier
prevented
progression
unresolved
inflammation.
In
conclusion,
our
study
demonstrated
could
alleviate
through
CA9/STIM1-mediated
providing
promising
candidate
UC.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: March 7, 2024
Abstract
Breast
cancer
is
a
complex
and
heterogeneous
disease,
encompassing
various
subtypes
characterized
by
distinct
molecular
features,
clinical
behaviors,
treatment
responses.
Categorization
of
based
on
the
presence
or
absence
estrogen
receptor
(ER),
progesterone
(PR),
human
epidermal
growth
factor
2
(HER2),
leading
to
such
as
luminal
A,
B,
HER2-positive,
triple-negative
breast
(TNBC).
TNBC,
comprising
around
20%
all
cancers,
lacks
expression
ER,
PR,
HER2
receptors,
rendering
it
unresponsive
targeted
therapies
presenting
significant
challenges
in
treatment.
TNBC
associated
with
aggressive
behavior,
high
rates
recurrence,
resistance
chemotherapy.
Tumor
initiation,
progression,
are
attributed
stem
cells
(BCSCs),
which
possess
self-renewal,
differentiation,
tumorigenic
potential.
Surface
markers,
self-renewal
pathways
(Notch,
Wnt,
Hedgehog
signaling),
apoptotic
protein
(Bcl-2),
angiogenesis
inhibition
(VEGF
inhibitors),
immune
modulation
(cytokines,
checkpoint
inhibitors)
among
key
targets
discussed
this
review.
However,
targeting
BCSC
subpopulation
presents
challenges,
including
off-target
effects,
low
solubility,
bioavailability
anti-BCSC
agents.
Nanoparticle-based
offer
promising
approach
target
cellular
processes
implicated
survival
BSCS
TNBC.
In
review,
we
explore
nanocarrier-based
approaches
for
BCSCs
aiming
overcome
these
improve
outcomes
patients.
These
nanoparticle-based
therapeutic
strategies
hold
promise
addressing
gap
delivering
while
minimizing
systemic
toxicity
enhancing
efficacy.
Graphical
abstract
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: Jan. 2, 2025
Abstract
Radiopharmaceuticals
involve
the
local
delivery
of
radionuclides
to
targeted
lesions
for
diagnosis
and
treatment
multiple
diseases.
Radiopharmaceutical
therapy,
which
directly
causes
systematic
irreparable
damage
cells,
has
attracted
increasing
attention
in
refractory
diseases
that
are
not
sensitive
current
therapies.
As
Food
Drug
Administration
(FDA)
approvals
[
177
Lu]Lu-DOTA-TATE,
Lu]Lu-PSMA-617
their
complementary
diagnostic
agents,
namely,
68
Ga]Ga-DOTA-TATE
Ga]Ga-PSMA-11,
radiopharmaceutical-based
theranostics
(radiotheranostics)
being
increasingly
implemented
clinical
practice
oncology,
lead
a
new
era
radiopharmaceuticals.
The
generation
radiopharmaceuticals
utilizes
targeting
vector
achieve
accurate
avoid
off-target
deposition,
making
it
possible
improve
efficiency
biosafety
tumour
therapy.
Numerous
studies
have
focused
on
developing
novel
broader
range
disease
targets,
demonstrating
remarkable
vivo
performance.
These
include
high
tumor
uptake,
prolonged
retention
time,
favorable
pharmacokinetic
properties
align
with
standards.
While
radiotheranostics
been
widely
applied
applications
now
expanding
neurodegenerative
diseases,
cardiovascular
inflammation.
Furthermore,
radiotheranostic-empowered
precision
medicine
is
revolutionizing
cancer
paradigm.
Diagnostic
play
pivotal
role
patient
stratification
planning,
leading
improved
therapeutic
outcomes
radionuclide
This
review
offers
comprehensive
overview
evolution
radiopharmaceuticals,
including
both
FDA-approved
clinically
investigated
explores
mechanisms
cell
death
induced
by
It
emphasizes
significance
future
prospects
theranostic-based
advancing
medicine.
