Comparative Analysis of Cytokine Expression Profiles in Prostate Cancer Patients DOI Creative Commons
Karoline Brito Caetano Andrade Coelho, Denise Kusma Wosniaki, Jônatas Luiz Pereira

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 505 - 505

Published: May 6, 2025

This study aimed to identify the cytokine expression profile in prostate cancer (PCa) patients compared healthy individuals. Plasma samples from 75 PCa and 14 controls were analyzed using Multiplex ELISA (Luminex) measure levels of 12 cytokines: IL-4, IL-5, IL-6, IL-10, IL-1β, IL-17A, IL-12p70, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, TNF-α, IFN-γ. Differences Mann–Whitney test, Wilcoxon’s rank-sum Spearman’s rank correlation, K-means Clustering unsupervised machine learning validate patterns. In patients, IFN-γ, interleukins exhibited significantly higher levels; conversely, TNF-α MCP-1/CCL2 both had decreased The clustering analysis confirmed that exclusively exhibit highest associations with IFN- γ, IL-5. Furthermore, specific correlations between IL-4 MIP-1 beta, IFN-gamma, IL-5 IFN-gamma did not occur Such results will guide forthcoming vitro vivo human cancer-drug treatment models, paving way for exploration future drug targets candidates potential predict FDA-approved responses by targeting oncogenesis pathways.

Language: Английский

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies DOI Creative Commons
Ruixue Bai, Yunong Li, Lingyan Jian

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: Sept. 8, 2022

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and key driver for cancer malignancy, it thought to be major target in treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells tumor microenvironment (TME), which have large impact on development immunotherapy. TAMs massively accumulate within hypoxic regions. represent deadly combination because has been suggested induce pro-tumorigenic macrophage phenotype. Hypoxia not only directly affects polarization, but also an indirect effect by altering communication between macrophages. For example, can influence expression chemokines exosomes, both profound impacts recipient cells. Recently, demonstrated intricate interaction TME relevant poor prognosis increased malignancy. However, there no comprehensive literature reviews molecular mechanisms underlying hypoxia-mediated TAMs. Therefore, this review aim collect all recently available data topic provide insights developing novel therapeutic strategies reducing effects hypoxia.

Language: Английский

Citations

163
Multifunctional nanoparticle-mediated combining therapy for human diseases DOI Creative Commons
Xiaotong Li,

Xiuju Peng,

Makhloufi Zoulikha

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

Citations

143
Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

26
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy DOI Creative Commons

Qinglong Ma,

Wenyang Zhang, Kongming Wu

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

Abstract KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis fatty acids nucleotides. However, beyond mechanisms KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related alterations cells explore prevalence significance mutation shaping tumor microenvironment influencing epigenetic modification via various molecular activities. Given rely these changes sustain cell growth survival, targeting processes may represent a promising therapeutic strategy for KRAS-driven cancers.

Language: Английский

Citations

6
Contribution of tumor microenvironment (TME) to tumor apoptosis, angiogenesis, metastasis, and drug resistance DOI
Yanhong Xiao, M Hassani,

Melina Barahouei Moghaddam

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 14, 2025

Language: Английский

Citations

4
The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management DOI Creative Commons
Amin Ullah, Jiao Wang, Bairong Shen

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: May 14, 2024

Abstract Reproductive cancers are malignancies that develop in the reproductive organs. One of leading affecting male system on a global scale is prostate cancer (PCa). The negative consequences PCa metastases endure and severe, significantly mortality life quality for those who affected. association between inflammation has captured interest while. Inflammatory cells, cytokines, CXC chemokines, signaling pathways, other elements make up tumor microenvironment (TME), which characterized by inflammation. cytokines chemokines especially crucial development prognosis. Cytokines (interleukins) such as IL-1, IL-6, IL-7, IL-17, TGF-β, TNF-α, CXCL1–CXCL6, CXCL8–CXCL16 thought to be responsible pleiotropic effects PCa, include inflammation, progression, angiogenesis, leukocyte infiltration advanced therapeutic resistance. inflammatory cytokine systems also promising candidates suppression immunotherapy. Therefore, purpose this work provide insight how spectra evolve develops spreads. We discussed recent developments our awareness diverse molecular pathways these circulating well their associated receptors, may one day serve PCa-targeted therapies. Moreover, current status potential theranostic therapies based receptors (CXCRs) examined.

Language: Английский

Citations

11
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis DOI Creative Commons

Hanqing Xu,

Yi He,

Sheng Chen

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114027 - 114027

Published: Jan. 12, 2025

Language: Английский

Citations

1
Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets DOI Creative Commons
Zonghao Liu, Xiaofang Zhang,

Theresa Ben

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 5, 2025

The tumour microenvironment is the "hotbed" of cells, providing abundant extracellular support for growth and metastasis. However, not static constantly remodelled by a variety cellular components, including through mechanical, biological chemical means to promote Focal adhesion plays an important role in cell-extracellular matrix adhesion. An in-depth exploration focal metastasis, especially their contribution at biomechanical level, direction current research. In this review, we first summarize assembly adhesions explore kinetics cells. Then, describe detail various stages its key functions cell migration, invasion, remodelling. Finally, anti-tumour strategies targeting progress development some inhibitors against proteins. paper, time that play positive feedback pro-tumour metastatic remodelling summarizing five processes multidimensional way. It beneficial researchers have deeper understanding behaviour metastasis potential as therapeutic target, new ideas prevention treatment metastases.

Language: Английский

Citations

1
Immunotherapy for Prostate Cancer: A Current Systematic Review and Patient Centric Perspectives DOI Open Access

Laeeq ur Rehman,

Muhammad Hassan Nisar,

Wajeeha Fatima

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(4), P. 1446 - 1446

Published: Feb. 11, 2023

Prostate cancer is the most commonly diagnosed in men worldwide, making up 21% of all cases. With 345,000 deaths per year owing to disease, there an urgent need optimize prostate care. This systematic review collated and synthesized findings completed Phase III clinical trials administering immunotherapy; a current trial index (2022) ongoing I-III records was also formulated. A total four with 3588 participants were included DCVAC, ipilimumab, personalized peptide vaccine, PROSTVAC vaccine. In this original research article, promising results seen for ipilimumab intervention, improved overall survival trends. 68 pooling 7923 included, spanning completion until June 2028. Immunotherapy emerging option patients cancer, immune checkpoint inhibitors adjuvant therapies forming large part landscape. various trials, characteristics premises prospective will be key improving outcomes future.

Language: Английский

Citations

22
The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis DOI Creative Commons

Ying-Li Yang,

Xiaofeng Li, Biao Song

et al.

Rheumatology and Therapy, Journal Year: 2023, Volume and Issue: 10(4), P. 793 - 808

Published: May 25, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia, inflammatory cell infiltration in joint cavity fluid, cartilage bone destruction, and deformation. C–C motif chemokine ligand 3 (CCL3) belongs to chemokine. It highly expressed immune cells. Increasingly, studies have shown that CCL3 can promote the migration factors tissue, destruction joint, angiogenesis, participate pathogenesis RA. These symptoms indicate expression correlated with RA disease. Therefore, this paper reviews possible mechanism RA, which may provide some new insights for diagnosis treatment

Language: Английский

Citations

21