The effect of caffeine on subsequent sleep: A systematic review and meta-analysis

Sleep Medicine Reviews, Journal Year: 2023, Volume and Issue: 69, P. 101764 - 101764

Published: Feb. 6, 2023

The consumption of caffeine in response to insufficient sleep may impair the onset and maintenance subsequent sleep. This systematic review meta-analysis investigated effect on characteristics night-time sleep, with intent identify time after which should not be consumed prior bedtime. A search literature was undertaken 24 studies included analysis. Caffeine reduced total by 45 min efficiency 7%, an increase latency 9 wake 12 min. Duration (+6.1 min) proportion (+1.7%) light (N1) increased intake duration (-11.4 (-1.4%) deep (N3 N4) decreased intake. To avoid reductions time, coffee (107 mg per 250 mL) at least 8.8 h bedtime a standard serve pre-workout supplement (217.5 mg) 13.2 results present study provide evidence-based guidance for appropriate mitigate deleterious effects

Language: Английский

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Metabolic diseases and healthy aging: identifying environmental and behavioral risk factors and promoting public health

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 13, 2023

Aging is a progressive and irreversible pathophysiological process that manifests as the decline in tissue cellular functions, along with significant increase risk of various aging-related diseases, including metabolic diseases. While advances modern medicine have significantly promoted human health extended lifespan, diseases such obesity type 2 diabetes among older adults pose major challenge to global public societies age. Therefore, understanding complex interaction between factors crucial for promoting well-being healthy aging. This review article explores environmental behavioral associated their impact on The environment, an obesogenic environment exposure toxins, strongly correlated rising prevalence its comorbidities. Behavioral factors, diet, physical activity, smoking, alcohol consumption, sleep patterns, influence throughout Public interventions targeting modifiable can effectively promote healthier lifestyles prevent Collaboration government agencies, healthcare providers community organizations essential implementing these creating supportive environments foster

Language: Английский

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Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 138 - 138

Published: Jan. 11, 2024

A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, in contemporary society, there a prevalent occurrence misalignments system environmental cues, phenomenon frequently associated with adverse health consequences. The onset most current chronic diseases intimately connected alterations lifestyle practices under various facets, including following: reduced physical activity, exposure artificial light, also acknowledged as light pollution, sedentary behavior coupled consuming energy-dense nutriments, irregular eating frameworks, disruptions sleep patterns (inadequate quality duration), engagement shift work, known jetlag. rapid evolution life domestic routines has significantly outpaced rate genetic adaptation. Consequently, underlying rhythms exposed multiple shifts, thereby elevating susceptibility disease predisposition. comprehensive review endeavors synthesize existing empirical evidence that substantiates conceptual integration clock, biochemical molecular homeostasis, oxidative stress, stimuli imparted exercise, sleep, nutrition.

Language: Английский

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Noradrenergiclocus coeruleusactivity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 22, 2023

Abstract The noradrenergic locus coeruleus (LC) is vital for brain states underlying wakefulness, whereas its roles sleep remain uncertain. Combining mouse sleep-wake monitoring, behavioral manipulations, LC fiber photometry and closed-loop optogenetics, we found that neuronal activity partitioned non-rapid-eye-movement (NREMS) into alternating autonomic rule the NREMS-REMS cycle. High levels generated an autonomic-subcortical arousal state facilitated cortical microarousals, while low were obligatory REMS entries. Timed optogenetic inhibition revealed this functional alternation set duration of cycle by ruling entries during undisturbed when pressure was high. A stimulus-enriched, stress-promoting wakefulness increased high at expense ones in subsequent NREMS, fragmenting NREMS through microarousals delaying onset. We conclude fluctuations gatekeep NREM-REMS over recurrent infraslow intervals, but they also convey vulnerability to adverse wake experiences.

Language: Английский

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Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Language: Английский

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Impact of Melatonin Supplementation on Sports Performance and Circulating Biomarkers in Highly Trained Athletes: A Systematic Review of Randomized Controlled Trials

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1011 - 1011

Published: March 30, 2024

Melatonin (N-acetyl-5 methoxytryptamine) is an indolic neurohormone that modulates a variety of physiological functions due to its antioxidant, anti-inflammatory, and immunoregulatory properties. Therefore, the purpose this study was critically review effects melatonin supplementation in sports performance circulating biomarkers related health status highly trained athletes. Data were obtained by performing searches following three bibliography databases: Web Science, PubMed, Scopus. The terms used “Highly Trained Athletes”, “Melatonin”, “Sports Performance”, “Health Biomarkers” using “Humans” as filter. search update carried out February 2024 from original articles published with controlled trial design. PRISMA rules, modified McMaster critical form for quantitative studies, PEDro scale, Cochrane risk bias applied. According inclusion exclusion criteria, 21 selected 294 references. dose supplemented trials ranged between 5 mg 100 administered before or after exercise. outcomes showed improvements antioxidant inflammatory response reversed liver damage muscle damage. Moderate on modulating glycemia, total cholesterol, triglycerides, creatinine reported. Promising data found regarding potential benefits hematological biomarkers, hormonal responses, performance. true efficiency directly improve remains be assessed. Nevertheless, indirect effect could evaluated through biomarkers.

Language: Английский

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Pyjamas, Polysomnography and Professional Athletes: The Role of Sleep Tracking Technology in Sport

Sports, Journal Year: 2023, Volume and Issue: 11(1), P. 14 - 14

Published: Jan. 5, 2023

Technological advances in sleep monitoring have seen an explosion of devices used to gather important metrics. These range from instrumented ‘smart pyjamas’ through at-home polysomnography devices. Alongside these developments technologies, there been concomitant increases athletic populations, both the research and practical settings. The increase sport is likely due increased knowledge importance recovery process performance athlete, as well well-reported challenges that athletes can face with their sleep. This narrative review will discuss: (1) athletes; (2) various wearable tools technologies being monitor setting; (3) role tracking may play gathering information about sleep; (4) reliability validity devices; (5) limitations cautions associated trackers; and, (6) use trackers guide behaviour change athletes. We also provide some recommendations for practitioners working ensure selection such technology meet goals requirements athlete.

Language: Английский

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Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care

Trends in cancer, Journal Year: 2023, Volume and Issue: 10(3), P. 196 - 207

Published: Nov. 23, 2023

Circadian timekeeping mechanisms and cell cycle regulation share thematic biological principles in responding to signals, repairing cellular damage, coordinating metabolism, allocating resources for optimal function. Recent studies show interactions between regulators circadian clock components, offering insights into potential cancer treatment approaches. Understanding control of metabolism informs timing therapies reduce adverse effects enhance efficacy. adaptability lifestyle factors, such as activity, sleep, nutrition sheds light on their impact cancer. Leveraging regulatory prevention care is vital, most risk stems from modifiable lifestyles. Monitoring factors aids assessment targeted interventions across the continuum.

Language: Английский

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Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

Nutrients, Journal Year: 2023, Volume and Issue: 15(3), P. 734 - 734

Published: Feb. 1, 2023

The circadian system in the human body responds to daily environmental changes optimise behaviour according biological clock and also influences various physiological processes. suprachiasmatic nuclei are located anterior hypothalamus of brain, they synchronise 24 h light/dark cycle. Human functions highly dependent on regulation internal clock. Skeletal muscles comprise largest collection peripheral clocks body. Both central regulate interaction between musculoskeletal energy metabolism. skeletal muscle plays a vital role lipid glucose pathogenesis osteoporosis is related an alteration rhythm. In present review, we discuss disturbance rhythm its resultant effect system. We nutritional strategies that potentially effective maintaining system's homeostasis. Active collaborations nutritionists physiologists field chronobiological chrononutrition will further clarify these interactions. This review may be necessary for successful interventions reducing morbidity mortality resulting from disturbances.

Language: Английский

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Crosstalk between circadian clocks and pathogen niche

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(5), P. e1012157 - e1012157

Published: May 9, 2024

Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation response to daily environmental changes. These manifest across entire organisms, various organs, through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, fungi, some which have their own while others influenced by the rhythmic environment hosts. Pathogens target specific tissues organs within host optimize replication. Diverse compositions interplay among cell types create unique microenvironments different tissues, distinctive biology. Hence, residing pathogens exposed cyclic conditions, can profoundly impact host–pathogen interactions. This review explores influence mammalian tissue-specific interactions on dynamics pathogen–host relationships. Overall, this demonstrates between body’s internal timekeeping system its susceptibility has implications for future infectious disease research treatment.

Language: Английский

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