Cited by 3D printing technology: A new approach for the fabrication of personalized and customized pharmaceuticals

The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective DOI

Markus Laubach, Frank Hildebrand, Sinduja Suresh

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(7), P. 341 - 341

Published: June 27, 2023

The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters, including the patient’s age, comorbidities, systemic disorders, anatomical location defect, surgeon’s preference experience. most used therapeutic modalities for regeneration long include distraction osteogenesis (bone transport), free vascularized fibular grafts, Masquelet technique, allograft, (arthroplasty with) mega-prostheses. Over past 25 years, three-dimensional (3D) printing, breakthrough layer-by-layer manufacturing technology that produces final parts directly from 3D model data, has taken off transformed enabling personalized therapies highly porous 3D-printed implants tailored to patient. Therefore, reduce morbidities complications associated current regimens, efforts have been made in translational research toward scaffolds facilitate regeneration. Three-dimensional printed should not only provide osteoconductive surfaces cell attachment subsequent formation also physical support containment graft material during process, enhancing ingrowth, while simultaneously, orthopaedic supply mechanical strength rigid, stable external and/or internal fixation. In this perspective review, we focus on elaborating history defect methods assessing approaches as well recent developments, existing evidence advantages disadvantages Furthermore, it is evident regulatory framework organization financing evidence-based trials very complex, new challenges non-biodegradable biodegradable emerging yet sufficiently addressed, such guideline development specific surgical indications, clinically feasible design concepts needed multicentre international preclinical trials, medico-legal status, reimbursement. These underscore need intensive exchange open honest debate among leaders field. This goal addressed well-planned focused stakeholder workshop topic patient-specific regeneration, proposed review.

Language: Английский

Citations

Recent Advances in the Applications of Additive Manufacturing (3D Printing) in Drug Delivery: A Comprehensive Review DOI

Derick Muhindo, Rasha M. Elkanayati, Priyanka Srinivasan

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(2)

Published: Feb. 9, 2023

Language: Английский

Citations

Review of vat photopolymerization 3D printing of photonic devices DOI

Dileep Chekkaramkodi,

Liya Jacob,

Muhammed Shebeeb C

et al.

Additive manufacturing, Journal Year: 2024, Volume and Issue: 86, P. 104189 - 104189

Published: April 1, 2024

Vat photopolymerization (VP) 3D printing, a subset of additive manufacturing, is renowned for its capability to create intricate structures with high precision, particularly useful in optical applications. The process involves using photosensitive resins cured layer by through various light-curing technologies like Stereolithography (SLA), Digital Light Processing (DLP), Two-Photon Polymerization (TPP), Continuous Liquid Interface Production (CLIP), and Crystal Display (LCD). Each technique offers unique advantages terms speed, resolution, material compatibility, TPP providing the highest resolution. This review explores diverse applications VP 3D-printed components, including lenses, waveguides, gratings, resonators, metamaterials, sensors, actuators, demonstrating their significant role advancing technology innovation. Challenges selection, post-processing requirements, size limitations, support are discussed, alongside potential future research directions. These include developing advanced photopolymer materials enhanced properties, hardware improvements higher resolution multi-material quality assurance measures ensuring precision. Despite some printing presents promising avenue rapid prototyping production complex, multifunctional devices, marking stride manufacturing technological development.

Language: Английский

Citations

The role of artificial intelligence in generating original scientific research DOI

Moe Elbadawi, Hanxiang Li, Abdul W. Basit

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 652, P. 123741 - 123741

Published: Jan. 3, 2024

Artificial intelligence (AI) is a revolutionary technology that finding wide application across numerous sectors. Large language models (LLMs) are an emerging subset of AI and have been developed to communicate using human languages. At their core, LLMs trained with vast amounts information extracted from the internet, including text images. Their ability create human-like, expert in almost any subject means they increasingly being used as aid presentation, particularly scientific writing. However, we wondered whether could go further, generating original research preparing results for publication. We tasked GPT-4, LLM, write pharmaceutics manuscript, on topic itself novel. It was able conceive hypothesis, define experimental protocol, produce photo-realistic images printlets, generate believable analytical data range instruments convincing publication-ready manuscript evidence critical interpretation. The model achieved all this less than 1h. Moreover, generated were multi-modal nature, thermal analyses, vibrational spectroscopy dissolution testing, demonstrating multi-disciplinary expertise LLM. One area which failed, however, referencing literature. Since appeared though, suggest certainly play role but input, interpretation validation. discuss potential benefits current bottlenecks realising ambition here.

Language: Английский

Citations

3D printing processes in precise drug delivery for personalized medicine DOI

Haisheng Peng, Bo Han, Tianjian Tong

et al.

Biofabrication, Journal Year: 2024, Volume and Issue: 16(3), P. 032001 - 032001

Published: April 3, 2024

Abstract With the advent of personalized medicine, drug delivery system will be changed significantly. The development medicine needs support many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing materials layer-by-layer based on computer-aided design method. Compared with traditional pharmaceutical processes, 3DP produces complex combinations, dosage, and flexible shape structure dosage forms (DFs) demand. In future, drugs may supplement even replace their counterpart. We systematically introduce applications technologies in industry summarize virtues shortcomings each technique. release behaviors control mechanisms DFs desired structures are also analyzed. Finally, benefits, challenges, prospects to discussed.

Language: Английский

Citations

Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology DOI

Anuj A. Biswas,

Madhukiran R. Dhondale,

Ashish Kumar Agrawal

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(6), P. 1458 - 1479

Published: Jan. 13, 2024

Language: Английский

Citations

Optimization of 4D/3D printing via machine learning: A systematic review DOI

Yakubu Adekunle Alli, Hazleen Anuar, Mohd Romainor Manshor

et al.

Hybrid Advances, Journal Year: 2024, Volume and Issue: 6, P. 100242 - 100242

Published: July 4, 2024

This systematic review explores the integration of 4D/3D printing technologies with machine learning, shaping a new era manufacturing innovation. The analysis covers wide range research papers, articles, and patents, presenting multidimensional perspective on advancements in additive manufacturing. underscores learning's pivotal role optimizing printing, addressing aspects like design customization, material selection, process control, quality assurance. examination reveals novel techniques enabling fabrication intelligent, self-adaptive structures capable transformation over time. Additionally, investigates use predictive algorithms to enhance efficiency, reliability, sustainability processes. Applications span aerospace, healthcare, architecture, consumer goods, showcasing potential create intricate, personalized, once-unattainable functional products. synergy between learning is poised unlock horizons, rapid responses market demands challenges. In summary, this provides comprehensive overview current state optimization through highlighting transformative interdisciplinary fusion offering roadmap for future development. It aims inspire innovators, researchers, industries harness powerful combination accelerated evolution processes into 21st century beyond.

Language: Английский

Citations

Clinical translation of advanced colonic drug delivery technologies DOI

Atheer Awad,

Christine M. Madla,

Laura E. McCoubrey

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 181, P. 114076 - 114076

Published: Dec. 8, 2021

Language: Английский

Citations

105

Accelerating 3D printing of pharmaceutical products using machine learning DOI

Jun Jie Ong,

Brais Muñiz Castro,

Simon Gaisford

et al.

International Journal of Pharmaceutics X, Journal Year: 2022, Volume and Issue: 4, P. 100120 - 100120

Published: June 10, 2022

Language: Английский

Citations

Predicting drug-microbiome interactions with machine learning DOI

Laura E. McCoubrey, Simon Gaisford, Mine Orlu

et al.

Biotechnology Advances, Journal Year: 2021, Volume and Issue: 54, P. 107797 - 107797

Published: July 11, 2021

Language: Английский

Citations