Bioactive polymers: A comprehensive review on bone grafting biomaterials

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134615 - 134615

Published: Aug. 10, 2024

Language: Английский

---

Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 280 - 280

Published: Sept. 25, 2024

Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased damaged osseous tissue. Functional scaffolds maintain structural integrity provide mechanical support defect site during healing process, while simultaneously enabling or improving through amplified cellular cues between scaffold native tissues. Ample research on functionalization has been conducted improve scaffold–host interaction, including fabrication techniques, biomaterial selection, surface modifications, integration bioactive molecular additives, post-processing modifications. Each these methods plays crucial role in not only but actively participate process bone joint surgery. This review provides state-of-the-art, comprehensive overview scaffold-based strategies used engineering, specifically for regeneration. Critical issues obstacles are highlighted, applications advances described, future directions identified.

Language: Английский

---

Development of porous hydroxyapatite/PVA/gelatin/alginate hybrid flexible scaffolds with improved mechanical properties for bone tissue engineering

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 319, P. 129332 - 129332

Published: April 18, 2024

Language: Английский

---

Clinical translation of personalized bioengineered implant scaffolds

Nature Reviews Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

---

Chitosan composite with mesenchymal stem cells: Properties, mechanism, and its application in bone regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133502 - 133502

Published: July 2, 2024

Language: Английский

---

Advancing Osteoporotic Bone Regeneration Through Tailored Tea Polyphenols Functionalized Micro‐/Nano‐ Hydroxyapatite Bioceramics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: May 6, 2024

Abstract Efforts to develop advanced bone substitutes for effective regeneration in substantial defects have led the fabrication of tissue‐engineered scaffolds. These scaffolds, featuring hierarchical structures, specific chemical compositions, and functional qualities, are essential mimicking native tissue. Inspired by biomineralization process, hydrothermal treatment is used synthesize micro‐/nano‐hydroxyapatite bioceramics functionalized with tea polyphenols (TP‐nwHA), closely resembling structure bone‐like apatite induced hydroxyapatite vivo. The vitro results demonstrate TP‐nwHA's superior biocompatibility, enhancing cell proliferation adhesion. Furthermore, TP‐nwHA scaffolds significantly influence mesenchymal stem cells, promoting osteogenic differentiation while inhibiting osteoclastogenic differentiation. upregulation proteins BMP2 ITGB1, along downregulation osteoclastic FGF21 IGFBP1, synergistic effect biomimetic on activation MAPK signaling pathway. In vivo, showe early angiogenic capabilities, leading improved critical‐size femoral osteoporotic rats. Histological staining confirms complete bridging new tissue group, nanoindentation tests indicate formation mature mineralized Collectively, these findings suggest a novel strategy fabricating bone‐mimicking constructs potential applications disease modeling.

Language: Английский

---

Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

---

Advances in growth factor-containing 3D printed scaffolds in orthopedics

BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems orthopedics can be solved through engineering, which used to treat fractures, defects, arthritis, etc. More importantly, it provide an alternative traditional grafting solve insufficient autologous grafting, poor histocompatibility grafts, induced regeneration. Growth factors are key by promoting osteoblast proliferation differentiation, turn increases efficiency osteogenesis 3D printing technology carriers with better pore structure for growth improve stability precisely control their release. Studies have shown that 3D-printed scaffolds containing choice personalized treatment, defect repair, regeneration orthopedics, important diseases potential value applications. This paper aims summarize progress printed recent years use different scaffolds, including morphogenetic proteins, platelet-derived factors, transforming vascular endothelial Optimization material selection way combining also discussed.

Language: Английский

---

Towards Stem Cell Therapy for Critical-Sized Segmental Bone Defects: Current Trends and Challenges on the Path to Clinical Translation

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(6), P. 145 - 145

Published: May 27, 2024

The management and reconstruction of critical-sized segmental bone defects remain a major clinical challenge for orthopaedic clinicians surgeons. In particular, regenerative medicine approaches that involve incorporating stem cells within tissue engineering scaffolds have great promise fracture management. This narrative review focuses on the primary components engineering—stem cells, scaffolds, microenvironment, vascularisation—addressing current advances translational regulatory challenges in landscape cell therapy defects. To comprehensively explore this research area offer insights future treatment options surgery, we examined latest developments advancements engineering, focusing those relevance recent years. Finally, present forward-looking perspective using

Language: Английский

---

Chemical modification of PLA for the design of 3D printed nanocomposite scaffolds with enhanced degradability for bone tissue engineering

Polymer Composites, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract In this study, 3D printing technology is used to develop nanocomposite scaffolds based on polylactic acid (PLA) and hydroxyapatite (HA). PLA was functionalized with itaconic anhydride (PLA f ) via radical grafting improve affinity the inorganic nanofiller accelerate hydrolytic degradation. Fourier‐transform infrared (FTIR) Nuclear Magnetic Resonance (NMR) spectroscopies confirmed occurrence of chemical functionalization. Preliminary characterization films PLA, relative nanocomposites through water contact angle measurements highlighted an increase wettability for , due hydrophilic groups grafted onto polymer chain. Thermal analysis showed glass transition temperature ( T g in nanocomposites, likely enhanced matrix‐nanoparticle interactions. Scanning electron microscopy (SEM) revealed more defined homogeneous fibers ‐HA5 ‐HA10, meanwhile results from compression tests indicated improved processability mechanical properties ‐based scaffolds, as evidenced by increased values Young modulus. Hydrolytic degradation studies Phosphate Buffered Saline (PBS) solution greater weight loss molecular decrease ‐HA5, suggesting faster hydrophilicity. Biological human Mesenchymal Stem Cells (hMSCs) demonstrated that all promoted cell proliferation, ‐HA formulations showing higher effect cellular behavior terms growth alkaline phosphatase (ALP) levels, indicating functionalization improves attachment, proliferation early osteogenic differentiation. Highlights Functionalization enhances hydrophilicity HA affinity. Nanocomposite are successfully developed printing. ink printability, making uniform structures. exhibit accelerated support adhesion

Language: Английский

---