Immunity Inflammation and Disease,
Journal Year:
2024,
Volume and Issue:
12(10)
Published: Oct. 1, 2024
Abstract
Background
Phytochemicals
possess
a
wide
range
of
anti‐tumor
properties,
including
the
modulation
autophagy
and
regulation
programmed
cell
death.
Autophagy
is
critical
process
in
cellular
homeostasis
its
dysregulation
associated
with
several
pathological
conditions,
such
as
cancer,
neurodegenerative
diseases,
diabetes.
In
plays
dual
role
by
either
promoting
tumor
growth
or
suppressing
it,
depending
on
context.
During
autophagy,
autophagosomes
engulf
cytoplasmic
components
proteins
organelles.
LC3‐II
(microtubule‐associated
protein
1
light
chain
3‐II)
an
established
marker
autophagosome
formation,
making
it
central
to
monitoring
mammals.
Objective
To
explore
regulatory
phytochemicals
LC3‐mediated
their
potential
therapeutic
impact
cancer.
The
review
emphasizes
involvement
promotion
suppression,
particularly
focusing
autophagy‐related
signaling
pathways
like
oxidative
stress
through
NRF2
pathway,
implications
for
genomic
stability
cancer
development.
Methods
focuses
comprehensive
analysis
bioactive
compounds
Curcumin,
Celastrol,
Resveratrol,
Kaempferol,
Naringenin,
Carvacrol,
Farnesol,
Piperine.
Literature
these
was
examined
assess
influence
LC3
expression,
tumor‐related
pathways.
A
systematic
literature
search
conducted
across
databases
PubMed,
Scopus,
Web
Science
from
inception
2023.
Studies
were
selected
prominent
databases,
roles
diagnosis
interventions,
relation
mechanisms.
Results
have
been
shown
modulate
levels
autophagic
flux
cells.
interaction
between
other
stress,
inflammation,
epigenetic
highlights
complex
biology.
For
instance,
Curcumin
Resveratrol
reported
induce
inhibit
type,
influencing
progression
responses.
Conclusion
Targeting
presents
promising
strategy
therapy.
suppression
promotion,
however,
necessitates
careful
consideration
context
which
induced
inhibited.
Future
research
should
aim
delineate
context‐specific
how
can
be
optimized
efficacy.
Novel
strategies
focus
use
fine‐tune
thereby
maximizing
inducing
death
Antioxidants,
Journal Year:
2022,
Volume and Issue:
11(8), P. 1481 - 1481
Published: July 28, 2022
Cancer
is
the
leading
cause
of
death
in
world.
Curcumin
main
ingredient
turmeric
(Curcuma
longa
L.),
and
widely
used
food
industry.
It
shows
anticancer
properties
on
different
types
cancers,
underlying
mechanisms
action
include
inhibiting
cell
proliferation,
suppressing
invasion
migration,
promoting
apoptosis,
inducing
autophagy,
decreasing
cancer
stemness,
increasing
reactive
oxygen
species
production,
reducing
inflammation,
triggering
ferroptosis,
regulating
gut
microbiota,
adjuvant
therapy.
In
addition,
curcumin
demonstrated
clinical
trials.
Moreover,
poor
water
solubility
low
bioavailability
can
be
improved
by
a
variety
nanotechnologies,
which
will
promote
its
effects.
Furthermore,
although
some
adverse
effects,
such
as
diarrhea
nausea,
it
generally
safe
tolerable.
This
paper
an
updated
review
prevention
management
cancers
with
special
attention
to
action.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(8), P. 1554 - 1554
Published: April 18, 2024
Cancer
is
a
life-threatening
disease
and
one
of
the
leading
causes
death
worldwide.
Despite
significant
advancements
in
therapeutic
options,
most
available
anti-cancer
agents
have
limited
efficacy.
In
this
context,
natural
compounds
with
diverse
chemical
structures
been
investigated
for
their
multimodal
properties.
Curcumin
polyphenol
isolated
from
rhizomes
Curcuma
longa
has
widely
studied
its
anti-inflammatory,
anti-oxidant,
effects.
acts
on
regulation
different
aspects
cancer
development,
including
initiation,
metastasis,
angiogenesis,
progression.
The
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(AKT)
pathway
key
target
therapy,
since
it
implicated
proliferation,
cell
survival.
found
to
inhibit
PI3K/Akt
tumor
cells,
primarily
via
mediators,
growth
factors,
protein
kinases,
cytokines.
This
review
presents
potential
curcumin
malignancies,
such
as
glioblastoma,
prostate
breast
cancer,
head
neck
cancers,
through
targeting
signaling
pathway.
Frontiers in Aging Neuroscience,
Journal Year:
2025,
Volume and Issue:
17
Published: Jan. 20, 2025
Aging
and
age-related
disease
are
among
the
most
common
challenging
issues
worldwide.
During
aging
process,
accumulation
of
oxidative
stress,
DNA
damage,
telomere
dysfunction,
other
related
changes
lead
to
cellular
dysfunction
development
diseases
such
as
neurodegenerative
cardiovascular
conditions.
Curcumin
is
a
widely-used
dietary
supplement
against
various
cancer,
diabetes,
aging.
This
agent
mediates
its
effects
through
several
mechanisms,
including
reduction
reactive
oxygen
species
(ROS)
stress-induced
well
modulation
subcellular
signaling
pathways
AMPK,
AKT/mTOR,
NF-κB.
These
involved
in
senescence
inflammation,
their
can
improve
cell
function
help
prevent
disease.
In
induce
apoptosis
variety
different
tumor
lines.
also
activates
redox
reactions
within
cells
inducing
ROS
production
that
leads
upregulation
receptors
on
membrane.
upregulate
expression
activity
p53
inhibits
proliferation
increases
apoptosis.
Furthermore,
curcumin
has
potent
inhibitory
effect
nuclear
factor
kappa
B
(NF-κB)
cyclooxygenase-2
(COX-2)
,
which
overexpression
antiapoptosis
genes
Bcl-2
.
It
attenuate
regulation
phosphoinositide
3-kinases
(
PI3K
)
increase
mitogen-activated
protein
kinases
(MAPKs)
endogenous
ROS.
Therefore,
herein,
we
aim
summarize
how
affect
epigenetic
processes
(such
stress)
order
change
aging-related
mechanisms.
discuss
roles
diseases,
Alzheimer,
Parkinson,
osteoporosis,
diseases.
Cells,
Journal Year:
2023,
Volume and Issue:
12(3), P. 458 - 458
Published: Jan. 31, 2023
Recent
evidence
suggests
that
autophagy
is
a
governed
catabolic
framework
enabling
the
recycling
of
nutrients
from
injured
organelles
and
other
cellular
constituents
via
lysosomal
breakdown.
This
mechanism
has
been
associated
with
development
various
pathologic
conditions,
including
cancer
neurological
disorders;
however,
recently
updated
studies
have
indicated
plays
dual
role
in
cancer,
acting
as
cytoprotective
or
cytotoxic
mechanism.
Numerous
preclinical
clinical
investigations
shown
inhibiting
enhances
an
anticancer
medicine’s
effectiveness
malignancies.
Autophagy
antagonists,
chloroquine
hydroxychloroquine,
previously
authorized
trials,
encouraging
medication-combination
therapies
targeting
autophagic
processes
for
cancer.
In
this
review,
we
provide
update
on
recent
research
examining
efficacy
combining
drugs
activate
inhibitors.
Additionally,
highlight
difficulties
progress
toward
using
treatment
strategy.
Importantly,
must
enable
use
suitable
inhibitors
coadministration
delivery
systems
conjunction
agents.
Therefore,
review
briefly
summarizes
general
molecular
process
behind
its
bifunctional
important
suppression
tumor
growth
resistance
to
chemotherapy
metastasis
regulation.
We
then
emphasize
how
cells
interacting
one
another
promising
therapeutic
target
treatment.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(7), P. 3525 - 3551
Published: May 3, 2024
Abstract
Colorectal
cancer
(CRC)
development
and
progression,
one
of
the
most
common
cancers
globally,
is
supported
by
specific
mechanisms
to
escape
cell
death
despite
chemotherapy,
including
cellular
autophagy.
Autophagy
an
evolutionarily
highly
conserved
degradation
pathway
involved
in
a
variety
processes,
such
as
maintenance
homeostasis
clearance
foreign
bodies,
its
imbalance
associated
with
many
diseases.
However,
role
autophagy
CRC
progression
remains
controversial,
it
has
dual
function,
affecting
either
or
survival,
senescence
tumor
therapy.
Indeed,
numerous
data
have
been
presented
that
serves
alternative
apoptosis
when
latter
ineffective
apoptosis‐resistant
cells,
which
why
also
referred
programmed
type
II.
Curcumin,
active
constituents
Curcuma
longa
,
great
potential
combat
influencing
various
signaling
pathways
epigenetic
regulation
safe
cost‐effective
approach.
This
review
discusses
efficacy
curcumin
against
vitro
vivo,
particularly
modulation
pathways.
While
clinical
studies
assessed
prevention
treatment,
none
specifically
examined
Nonetheless,
we
offer
overview
correlations
support
use
this
polyphenol
prophylactic
co‐therapeutic
agent
CRC.
Nanomaterials,
Journal Year:
2022,
Volume and Issue:
12(3), P. 324 - 324
Published: Jan. 20, 2022
Colorectal
cancer
is
the
third
most
common
cancer.
Because
curcumin
(CUR)
has
anti-inflammatory
and
anticancer
properties,
research
been
undertaken
to
indicate
that
nanocurcumin
compounds
can
be
used
treat
a
variety
of
cancers.
CUR
in
nanoform
found
have
stronger
effect
than
conventional
CUR.
The
purpose
this
study
was
show
CUR-loaded
poly
lactic-co-glycolic
acid
nanoparticles
(PLGA)
(CUR-loaded
PLGA)
effects
on
colon
carcinogenesis
male
dimethyl
hydrazine
(DMH)
mice
as
comparative
between
normal
curcumin,
focusing
nanocurcumin.
Mice
were
separated
into
six
groups:
No
treatment
given
Group
I
(negative
Group-I).
II
treated
with
III
PLGA.
IV
DMH.
V
received
DMH
curcumin.
VI
At
conclusion
trial,
animals
slain
(6
weeks).
Inflammatory
indicators
vascular
endothelial
growth
factor
(VEGF)
levels
all
changed
significantly
study,
following
inflammatory
markers
TNF
showed
percent
change
compared
group.
Recovery
percentage
for
Groups
VI,
respectively,
9.18
55.31%.
In
addition,
IL1
7.45
50.37%
respectively.
results
IL6
4.86
25.79%
recovery
16.98
45.12%
Following
mucosa
shape,
researchers
looked
at
PLGA
histology.
It
shown
affects
cell
cycle
PCNA
expression.
We
conclude
an
important
cancer-fighting
agent.
