Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 574 - 591
Published: Jan. 24, 2025
Language: Английский
Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 21(1)
Published: Dec. 4, 2023
Abstract Polyamines are essential for the growth and proliferation of mammalian cells intimately involved in biological mechanisms such as DNA replication, RNA transcription, protein synthesis, post-translational modification. These regulate cellular proliferation, differentiation, programmed cell death, formation tumors. Several studies have confirmed positive effect polyamines on maintenance health, while others demonstrated that their activity may promote occurrence progression diseases. This review examines a variety topics, polyamine source metabolism, including transport, potential impact health disease. In addition, brief summary effects oncogenes signaling pathways tumor metabolism is provided.
Language: Английский
Citations
57
Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(8), P. 569 - 589
Published: June 5, 2024
Language: Английский
Citations
48
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
The intestinal and intratumoral microbiota are closely associated with tumor progression response to antitumor treatments. antibacterial or microenvironment (TME)-modulating approaches have been shown markedly improve efficacy, strategies focused on normalizing the microbial environment rarely reported. Here, we reported development of an orally administered inulin-based hydrogel colon-targeting retention effects, containing hollow MnO 2 nanocarrier loaded chemotherapeutic drug Oxa (Oxa@HMI). On one hand, beneficial bacteria in colon specifically metabolized Oxa@HMI, resulting degradation inulin generation short-chain fatty acids (SCFAs). These SCFAs play a crucial role modulating stimulating immune responses. other matrix underwent microbiota-specific degradation, enabling targeted release production reactive oxygen species acidic TME. In this study, established, for first time, microbiota-targeted delivery system Oxa@HMI that exhibited high efficiency colorectal cancer targeting retention. promoted chemotherapy activated responses by intervening within tissue, providing clinical approach treatment susceptible invasion.
Language: Английский
Citations
21
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 11, 2025
Extracellular vesicles (EVs) are relevant elements for cell-to-cell communication and considered crucial in host-pathogen interactions by transferring molecules between the pathogen host during infections. These structures participate various physiological pathological processes promising candidates as disease markers, therapeutic reagents, drug carriers. Both H. pylori epithelial cells infected secrete EVs, which contribute to inflammation development of phenotypes. However, many aspects cellular molecular biology EV functions remain incompletely understood due methodological challenges studying these small structures. This review also highlights roles EVs derived from pylori-infected pathogenesis gastric extragastric diseases. Understanding specific infections, whether advantageous or pathogen, may help new approaches prevent disease.
Language: Английский
Citations
2
npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)
Published: Oct. 9, 2023
Abstract Recent evidence suggests that some human cancers may harbor low-biomass microbial ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in this context, are suggested by these studies to localize within cancer cells, immune cells other tumor microenvironment cell types, where they postulated impact multiple cancer-related functions. Herein, we provide an overview of intratumoral while focusing on intracellular their molecular activities, communication networks, host invasion evasion strategies, long-term colonization capacity. We highlight how integration sequencing-based spatial techniques enable recognition bacterial niches. discuss pitfalls, debates challenges decisively proving existence function microbes, reaching a mechanistic elucidation impacts behavior treatment responses. Together, causative understanding possible roles played bacteria future utilization diagnosis, patient stratification, treatment.
Language: Английский
Citations
38
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 16, 2024
Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.
Language: Английский
Citations
14
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: May 8, 2024
Abstract Fusobacterium nucleatum , a gram-negative oral bacterium, has been consistently validated as strong contributor to the progression of several types cancer, including colorectal (CRC) and pancreatic cancer. While previous in vitro studies have shown that intracellular F. enhances malignant phenotypes such cell migration, dependence this regulation on features tumor microenvironment (TME) oxygen levels are wholly uncharacterized. Here we examine influence hypoxia facilitating invasion its effects host responses focusing changes global epigenome transcriptome. Using multiomic approach, analyze epigenomic alterations H3K27ac transcriptomic sustained within normoxia conditioned CRC line HCT116 at 24 h following initial infection with . Our findings reveal activates signaling pathways biological processes cells similar those induced upon conditioning absence infection. Furthermore, show hypoxic TME favors persistence therefore under may amplify transformation by exacerbating alone. These results motivate future investigate host-microbe interactions tissue relevant conditions more accurately define parameters for targeted cancer therapies.
Language: Английский
Citations
13
iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893
Published: May 3, 2024
Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.
Language: Английский
Citations
9
Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115516 - 115516
Published: Jan. 1, 2025
Language: Английский
Citations
1
Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 59 - 76
Published: Jan. 1, 2025
The intratumoral microbiota, an integral part of liver tumors, has garnered significant attention from researchers due to its role in tumor development regulation and impact on cancer treatment. Intratumoral microorganism not only influences tumorigenesis progression, but also serves as potential biomarkers targets for therapy. Targeted manipulation these microorganisms holds great promise personalized However, there is a lack systematic summaries reports the study hepatocellular carcinoma. This comprehensive review aims address this gap by summarizing research progress related field carcinoma bacteria, including their sources, types, distribution characteristics within development, underlying mechanisms, application prospects. Through analysis, it proposed that intratumor organisms can be used markers diagnosis treatment, drug carrier materials targeting tissues, prospects developing new combination therapies based in-depth understanding interactions between microenvironment, immune cells, etc. well exploring interactions. It hoped perspective theoretical support provided future targeted therapy insights ideas points methods research.
Language: Английский
Citations
1