Frank Beach Award Winner: The centrality of the hypothalamic-pituitary-adrenal axis in dealing with environmental change across temporal scales

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 150, P. 105311 - 105311

Published: Jan. 25, 2023

Language: Английский

---

Climate change and its effects on body size and shape: the role of endocrine mechanisms

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2024, Volume and Issue: 379(1898)

Published: Feb. 5, 2024

In many organisms, rapidly changing environmental conditions are inducing dramatic shifts in diverse phenotypic traits with consequences for fitness and population viability. However, the mechanisms that underlie these responses remain poorly understood. Endocrine signalling systems often influence suites of sensitive to changes conditions; they thus ideal candidates uncovering both plastic evolved climate change. Here, we use body size shape, a set integrated predicted shift response rising temperatures effects on fitness, insulin-like growth factor-1 as case study explore ideas. We review what is known about shape then illustrate why endocrine likely be critical mediating effects. Lastly, discuss research approaches will advance understanding processes rapid change role have. Knowledge involved essential predicting ecological long-term evolutionary warming climate. This article part theme issue ‘Endocrine variation: conceptual recent developments’.

Language: Английский

---

Effects of testosterone on gene expression are concordant between sexes but divergent across species of Sceloporus lizards

The American Naturalist, Journal Year: 2024, Volume and Issue: 204(5), P. 517 - 532

Published: July 15, 2024

AbstractHormones mediate sexual dimorphism by regulating sex-specific patterns of gene expression, but it is unclear how much this regulation involves hormone levels versus transcriptomic responses to the same hormonal signal. Moreover, hormones can evolve, extent which pleiotropy in conserved across closely related species not well understood. We addressed these issues elevating testosterone juvenile females and males three

Language: Английский

---

The Ancestral Modulation Hypothesis: Predicting Mechanistic Control of Sexually Heteromorphic Traits Using Evolutionary History

The American Naturalist, Journal Year: 2023, Volume and Issue: 202(3), P. 241 - 259

Published: April 12, 2023

AbstractAcross the animal kingdom there are myriad forms within a sex across, and even within, species, rendering concepts of universal traits moot. The mechanisms that regulate development these trait differences varied, although in vertebrates, common pathways involve gonadal steroid hormones. Gonadal steroids often associated with heteromorphic development, where found at higher circulating levels is one involved for sex. Occasionally, situations which or monomorphic another We propose verbal hypothesis, ancestral modulation hypothesis (AMH), uses evolutionary history trait-particularly ancestrally possessed values-to predict regulatory pathway governs expression. AMH predicts genomic architecture appears first to resolve sexual conflict an initially trait. This takes advantage existing sex-biased signals, pathway, generate heteromorphism. In cases other experiences pressure new phenotype, will co-opt by altering its signal match original high-trait-value describe integrated needed produce this pattern what expected outcomes be given present framework as testable scientific community investigate create further engagement analysis both ultimate proximate approaches

Language: Английский

---

Species differences in hormonally mediated gene expression underlie the evolutionary loss of sexually dimorphic coloration in Sceloporus lizards

Journal of Heredity, Journal Year: 2023, Volume and Issue: 114(6), P. 637 - 653

Published: July 27, 2023

Abstract Phenotypic sexual dimorphism often involves the hormonal regulation of sex-biased expression for underlying genes. However, it is generally unknown whether evolution hormonally mediated occurs through upstream changes in tissue sensitivity to hormone signals, downstream responsiveness target genes, or both. Here, we use comparative transcriptomics explore these possibilities 2 species Sceloporus lizards exhibiting different patterns dichromatism. Sexually dimorphic S. undulatus develops blue and black ventral coloration response testosterone, while sexually monomorphic virgatus does not, despite similar sex differences circulating testosterone levels. We administered implants juveniles each used RNAseq quantify gene skin. Transcriptome-wide responses were stronger than virgatus, suggesting this signal. Species genes androgen metabolism hormone-binding globulin consistent with idea, but receptor was higher complicating interpretation. Downstream signaling, found clear related melanin synthesis, which upregulated by undulatus, not virgatus. Collectively, our results indicate that synthesis pathways contributes development contribute evolutionary loss coloration.

Language: Английский

---

Ontogenetic Change in Male Expression of Testosterone-Responsive Genes Contributes to the Emergence of Sex-Biased Gene Expression in Anolis sagrei

Frontiers in Physiology, Journal Year: 2022, Volume and Issue: 13

Published: June 2, 2022

Sex differences in gene expression tend to increase with age across a variety of species, often coincident the development sexual dimorphism and maturational changes hormone levels. However, because most transcriptome-wide characterizations divergence are framed as comparisons sex-biased ages, it can be difficult determine extent which age-biased within each sex contributes emergence expression. Using RNAseq liver sexually dimorphic brown anole lizard ( Anolis sagrei ), we found that pronounced was associated much greater degree males than females. This pattern suggests developmental males, such increases circulating testosterone, contribute disproportionately ontogenetic To test this hypothesis, used four different experimental contrasts independently characterize sets genes whose differed function castration and/or treatment exogenous testosterone. We were significantly male-biased or upregulated matured tended by whereas female-biased downregulated Moreover, first two principal components describing multivariate indicated testosterone reversed many feminizing effects on transcriptome maturing males. Collectively, our results suggest occur liver, these orchestrated androgens

Language: Английский

---

Activational vs. organizational effects of sex steroids and their role in the evolution of reproductive behavior: Looking to foot-flagging frogs and beyond

Hormones and Behavior, Journal Year: 2022, Volume and Issue: 146, P. 105248 - 105248

Published: Aug. 30, 2022

Language: Английский

---

A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphs

Authorea (Authorea), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 22, 2022

Reproductive phenotypes are shaped by genetic, physiological and environmental variation that an organism experiences during ontogeny. Steroid hormones play integrative role in this process through both genomic non-genomic pathways. Differences steroid hormone metabolism may be rooted variation. Here we evaluate the influence of supergene variants underlying alternative reproductive tactics on sex ontogeny ruffs (Calidris pugnax). Adult ruff males exhibit three male mating morphs called Independents, Faeders Satellites, differ prominently circulating androgen (testosterone androstenedione) concentrations. Across sexes chicks showed similar mean concentrations ontogenetic development. However, variances androgens same pattern as corresponding previously observed adults. HSD17B2 had been identified a key gene for mediating differences levels between it encodes enzyme converts testosterone to androstenedione is located within supergene. Observed expression embryonic brain tissue was consistent with predictions based genetic endocrine differences. Taken together, point synthesis mechanism shapes developmental trajectories organization among morphs.

Language: Английский

---

Evolutionary Loss of Male-Specific Coloration Is Associated with the Loss of Androgen Receptor Expression in Skin of Sceloporus Lizards

Deleted Journal, Journal Year: 2024, Volume and Issue: 97(5), P. 315 - 325

Published: Aug. 15, 2024

AbstractHormones can induce trait development in one species yet have no effect on the same a closely related species, but mechanisms underlying these differences are unclear. Here, we compare two lizard to explore cellular associated with evolutionary loss of hormonally mediated ventral coloration. The eastern fence (

Language: Английский

---

Epigenetic regulation of nuclear receptors: Implications for endocrine-related diseases and therapeutic strategies

Genes & Diseases, Journal Year: 2024, Volume and Issue: 12(4), P. 101481 - 101481

Published: Dec. 4, 2024

The expression and function of the receptor are controlled by epigenetic changes, such as DNA methylation, histone modification, noncoding RNAs. These modifications play a pivotal role in activity can lead to or exacerbate endocrine-related diseases. This review examines alterations nuclear receptors their significant impact on conditions diabetes, thyroid disorders, tumors. It highlights current therapies targeting these mechanisms, including gene editing, drugs, various other therapeutic approaches. offers fresh insight into mechanisms endocrine-associated highlighting latest progress development novel that be used address receptor-endocrine interactions.

Language: Английский

---