Metabolic Engineering: Methodologies and Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 123(9), P. 5521 - 5570

Published: Dec. 30, 2022

Metabolic engineering aims to improve the production of economically valuable molecules through genetic manipulation microbial metabolism. While discipline is a little over 30 years old, advancements in metabolic have given way industrial-level molecule benefitting multiple industries such as chemical, agriculture, food, pharmaceutical, and energy industries. This review describes design, build, test, learn steps necessary for leading successful campaign. Moreover, we highlight major applications engineering, including synthesizing chemicals fuels, broadening substrate utilization, improving host robustness with focus on specific case studies. Finally, conclude discussion perspectives future challenges related engineering.

Language: Английский

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Carrageenan From Kappaphycus alvarezii (Rhodophyta, Solieriaceae): Metabolism, Structure, Production, and Application

Frontiers in Plant Science, Journal Year: 2022, Volume and Issue: 13

Published: May 10, 2022

Carrageenan is a polysaccharide derived from red algae (seaweed) with enormous economic potential in wide range of industries, including pharmaceuticals, food, cosmetics, printing, and textiles. primarily produced through aquaculture-based seaweed farming, Eucheuma Kappaphycus species accounting for more than 90% global output. There are three major types carrageenan found algae: kappa ( κ )-, iota ι lambda λ )-carrageenan. alvarezii the most common kappa-carrageenan source, it farmed Asian countries such as Indonesia, Philippines, Vietnam, Malaysia. extracted K. has recently received lot attention due to its applications. This review will discuss terms metabolic physicochemical structure, extraction methods factors affecting production yield, well current future

Language: Английский

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Bioactive compounds for human and planetary health

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 17, 2023

Bioactive compounds found in edible plants and foods are vital for human planetary health, yet their significance remains underappreciated. These natural bioactives, as part of whole diets, ingredients, or supplements, can modulate multiple aspects health wellness. Recent advancements omic sciences computational biology, combined with the development Precision Nutrition, have contributed to convergence nutrition medicine, well more efficient affordable healthcare solutions that harness power food prevention therapy. Innovation this field is crucial feed a growing global population sustainably healthily. This requires significant changes our system, spanning agriculture, production, distribution consumption. As we facing pressing challenges, investing bioactive-based an opportunity protect biodiversity soils, waters, atmosphere, while also creating value consumers, patients, communities, stakeholders. Such research innovation targets include alternative proteins, such cellular agriculture plant-derived protein; extracts improve shelf-life preservatives; upcycling agricultural by-products reduce waste; alternatives synthetic fertilizers pesticides. Translational bioactives currently being developed at two levels, using systems-oriented approach. First, biological level, interplay between these host microbiome elucidated through omics research, big data artificial intelligence, accelerate both discovery validation. Second, ecosystem efforts focused on producing diverse nutrient-rich, flavorful, resilient, high-yield crops, educating consumers make informed choices benefit planet. Adopting system-oriented perspective helps: unravel intricate dynamic relationships nutrition, sustainability outcomes, harnessing nature promote wellbeing; foster sustainable ecosystem. Interdisciplinary collaboration needed new era practical food-based some most challenges humanity planet today.

Language: Английский

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Recent advances in biotechnological valorization of agro-food wastes (AFW): Optimizing integrated approaches for sustainable biorefinery and circular bioeconomy

Bioresource Technology Reports, Journal Year: 2024, Volume and Issue: 26, P. 101823 - 101823

Published: March 24, 2024

Achieving renewable clean energy to meet increasing global demand and counter overreliance on depleting unsustainable sources has recently drawn significant research interest. Similarly, attain the sustainable development goals (SDGs) "zero hunger" agenda, massive agricultural/food productions are embarked on, leading increased agro-food waste (AFW) generation with enormous handling costs evade its contribution environmental pollution. The advent of biorefineries fostered a healthy balance for tackling challenges from AFW – thereby promoting circular bioeconomy (CBE). Integrating several emerging microbial/enzymatic bioconversion processes facilitated overall increase in process efficiency. This review, therefore, provides extensive information ecological impacts AFW, as well biorefinery sustainability. We also critically reviewed advances integrated engineering valorization. Finally, limitations prospects real-life application these recent approaches were suggested.

Language: Английский

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Seaweed Proteins: A Step towards Sustainability?

Nutrients, Journal Year: 2024, Volume and Issue: 16(8), P. 1123 - 1123

Published: April 10, 2024

This review delves into the burgeoning field of seaweed proteins as promising alternative sources protein. With global demand escalating and concerns over traditional protein sources' sustainability ethics, emerges a viable solution, offering high content minimal environmental impacts. Exploring nutritional composition, extraction methods, functional properties, potential health benefits proteins, this provides comprehensive understanding. Seaweed contains essential amino acids, vitamins, minerals, antioxidants. Its ranges from 11% to 32% dry weight, making it valuable for diverse dietary preferences, including vegetarian vegan diets. Furthermore, underscores advantages production compared sources. cultivation requires resources, mitigating issues like ocean acidification. As specific types, methodologies, highlights versatility in various food products, plant-based meats, dairy alternatives, supplements. Additionally, discusses associated with such their unique acid profile bioactive compounds. Overall, aims provide insights proteins' applications role addressing needs sustainably.

Language: Английский

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Marine Algae Polysaccharides: An Overview of Characterization Techniques for Structural and Molecular Elucidation

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 105 - 105

Published: Feb. 27, 2025

Polysaccharides make up a large portion of the organic material from and in marine organisms. However, their structural characterization is often overlooked due to complexity. With many high-value applications unique bioactivities resulting polysaccharides’ complex heterogeneous structures, dedicated analytical efforts become important achieve elucidation. Because algae represent largest resource polysaccharides, majority discussion focused on well-known algae-based hydrocolloid polymers. The native environment polysaccharides presents challenges conventional techniques necessitating novel methodologies. We aim deliver review current state art polysaccharide characterization, capabilities as well limitations context environments. This covers extraction isolation addition characterizations monosaccharides secondary tertiary highlighting suite techniques.

Language: Английский

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Fucoidan from Marine Macroalgae: Biological Actions and Applications in Regenerative Medicine, Drug Delivery Systems and Food Industry

Bioengineering, Journal Year: 2022, Volume and Issue: 9(9), P. 472 - 472

Published: Sept. 14, 2022

The marine macroalgae produce a collection of bioactive polysaccharides, which the sulfated heteropolysaccharide fucoidan produced by brown algae class Phaeophyceae has received worldwide attention because its particular biological actions that confer nutritional and health benefits to humans animals. are determined their structure chemical composition, largely influenced geographical location, harvest season, extraction process, etc. This review discusses structure, composition physicochemical properties fucoidan. action applications for human health, tissue engineering, regenerative medicine drug delivery also addressed. industrial scenario prospects research depicted would give an insight into developing as commercially viable sustainable material in pharmacological sectors.

Language: Английский

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Promising biorefinery products from marine macro and microalgal biomass: A review

Renewable and Sustainable Energy Reviews, Journal Year: 2023, Volume and Issue: 190, P. 114081 - 114081

Published: Nov. 18, 2023

Language: Английский

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Ulvan from green macroalgae: Bioactive properties advancing tissue engineering, drug delivery systems, food industry, agriculture and water treatment

Bioresource Technology Reports, Journal Year: 2023, Volume and Issue: 22, P. 101457 - 101457

Published: April 29, 2023

Language: Английский

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Direct and robust citramalate production from brown macroalgae using fast-growing Vibrio sp. dhg

Bioresource Technology, Journal Year: 2024, Volume and Issue: 394, P. 130304 - 130304

Published: Jan. 10, 2024

Language: Английский

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