Increased atherogenicity in mood disorders: a systematic review, meta-analysis and meta-regression

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106005 - 106005

Published: Jan. 8, 2025

Language: Английский

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Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

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Simple dysmood disorder, a mild subtype of major depression, is not an inflammatory condition: Depletion of the compensatory immunoregulatory system

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 375, P. 75 - 85

Published: Jan. 21, 2025

Language: Английский

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T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 64, P. 171 - 181

Published: Nov. 13, 2023

Immune-inflammatory pathways in major depressive disorder are confined to the dysmood (MDMD) phenotype (Maes et al., 2022). No studies have addressed immune profile of first episode MDMD (FE-MDMD).

Language: Английский

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The effects of adverse childhood experiences on depression and suicidal behaviors are partially mediated by neuroticism: A subclinical manifestation of major depression

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: April 26, 2023

Neuroticism, a personality trait, can predict major depressive disorder (MDD). The current study aims to determine whether a) neuroticism is feature of the acute state MDD, including suicidal behaviors (SB); and b) adverse childhood experiences (ACEs) are associated with in MDD.

Language: Английский

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Lower Nerve Growth Factor Levels in Major Depression and Suicidal Behaviors: Effects of Adverse Childhood Experiences and Recurrence of Illness

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(7), P. 1090 - 1090

Published: July 18, 2023

Major depressive disorder (MDD) and its severe subtype, major dysmood (MDMD), are distinguished by activation of inflammatory growth factor subnetworks, which associated with recurrence illness (ROI) adverse childhood experiences (ACEs). Nerve (NGF) plays a crucial role in facilitating neuro-immune communications may regulate the response.

Language: Английский

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T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: April 17, 2023

Abstract Background Immune-inflammatory pathways in major depressive disorder are confined to the dysmood (MDMD) phenotype (Maes et al., 2022). No studies have addressed immune profile of first episode MDMD (FE-MDMD). Methods This study examines 48 cytokines/chemokines/growth factors, and classical M1, alternative M2, T helper (Th)-1, Th-2, Th-17 phenotypes, immune-inflammatory response system (IRS), compensatory immunoregulatory (CIRS), neuro-immunotoxicity profiles acute phase FE-MDMD (n=71) versus healthy controls (40). Results patients show significantly activated Th-1, IRS, CIRS, neurotoxicity, but not Th-2 or Th-17, compared controls. is accompanied by Th-1 polarization, while there no changes M1/M2 IRS/CIRS ratios. The top single indicator was far interleukin (IL)-16, followed at a distance TRAIL, IL-2R, tumor necrosis factor (TNF)-β. severity depression anxiety strongly associated with IRS (positively) (inversely) profiles, whereas suicidal behavior M1 activation. Around 56-60% variance depression, anxiety, scores explained IL-16, platelet-derived growth (PDGF) (both positively), IL-1 receptor antagonist (inversely). Increased neurotoxicity mainly driven TNF-α, IL-6 chemokine (CCL2, CCL11, CXCL1, CXCL10) signaling. Antidepressant-treated an increased ratio as drug-naïve patients. Conclusions positive regulation polarization cell activation (via binding IL-16 CD4), TNF, chemokine,

Language: Английский

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Redefining Autoimmune Disorders’ Pathoetiology: Implications for Mood and Psychotic Disorders’ Association with Neurodegenerative and Classical Autoimmune Disorders

Cells, Journal Year: 2023, Volume and Issue: 12(9), P. 1237 - 1237

Published: April 25, 2023

Although previously restricted to a limited number of medical conditions, there is growing appreciation that 'autoimmune' (or immune-mediated) processes are important aspects wide array diverse including cancers, neurodegenerative diseases and psychiatric disorders. All these classes conditions associated with alterations in mitochondrial function across an cell types. Accumulating data indicate the presence melatonergic pathway possibly all body cells, consequences for pathways crucial driving CD8+ T B-cell 'autoimmune'-linked processes. Melatonin suppression coupled upregulation oxidative stress suppress PTEN-induced kinase 1 (PINK1)/parkin-driven mitophagy, raising levels major histocompatibility complex (MHC)-1, which underpins chemoattraction cells activation antibody-producing B-cells. Many factors closely autoimmunity, gut microbiome/permeability, circadian rhythms, aging, aryl hydrocarbon receptor, brain-derived neurotrophic factor (BDNF) its receptor tyrosine B (TrkB) interact pathway. A future research directions novel treatment implications indicated this collection poorly conceptualized treated presentations. It proposed etiology many 'autoimmune'/'immune-mediated' disorders should be as significantly determined by dysregulation, being aspect pathoetiologies.

Language: Английский

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In major dysmood disorder, physiosomatic, chronic fatigue and fibromyalgia symptoms are driven by immune activation and increased immune-associated neurotoxicity

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 28, 2024

Abstract Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood (MDMD), associated with adverse childhood experiences (ACEs) negative life events (NLEs) which induce cytokines/chemokines/growth factors. To delineate the impact of ACE + NLEs on FF symptoms in first episode (FE)-MDMD, examine whether these effects are mediated immune profiles. ACEs, NLEs, symptoms, 48 factors were measured 64 FE-MDMD patients 32 normal controls. Physiosomatic, gastro-intestinal belong to same factor as depression, anxiety, melancholia, insomnia. extracted from seven domains labeled physio-affective phenome depression. A part (59.0%) variance explained independent interleukin (IL)-16 IL-8 (positively), CCL3 IL-1 receptor antagonist (inversely correlated). (46.5%) (IL)-16, TNF-related apoptosis-inducing ligand (TRAIL) (positively) combined activities immunoregulatory cytokines associated). Partial least squares analysis shows that exert a substantial influence partly an network composed interleukin-16, CCL27, TRAIL, macrophage-colony stimulating factor, stem cell growth factor. caused immune-associated neurotoxicity due T helper (Th)-1 polarization M1 macrophage activation relative lowered compensatory protection.

Language: Английский

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Effects of recurrence of illness and adverse childhood experiences on effector, cytotoxic, and regulatory T cells, and cannabinoid receptor-bearing B cells in major depression, an autoimmune disorder

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 13, 2023

Abstract Background Major depressive disorder (MDD) is characterized by increased T helper (Th)1 polarization, cell activation (e.g., CD71+ and CD40L+), cannabinoid receptor type 2 bearing CD20+ B cells; lower regulatory (Treg) numbers. Aims To delineate the effects of adverse childhood experiences (ACEs) recurrence illness (ROI) on activated CB2-bearing populations, Tregs, including FoxP3+CD152+, FoxP3+GARP+, FoxP3+CB1+ cells. Methods We measured ROI, ACEs, number cells, CD20+CB2+ in 30 MDD patients 20 healthy controls. Results A larger part variance depression phenome (40.8%) was explained lowered Tregs. ROI lifetime suicidal behaviors were significantly positively associated with CD20+CB2+, CD3+CD71+, CD3+CD40L+, CD4+CD71+, CD4+CD40L+, CD4HLADR+ correlated CD8+CD40L+ The sum ACEs CD4+40L+ numbers, (positively) Treg (inversely) indices. One replicable latent vector could be extracted from current behaviors, episodes, severity depression, 48.8% its ACEs. Conclusions ACE-induced effector cytotoxic cells autoimmune potential, coupled numbers are a key component depression. findings indicate that increasing caused processes, which consequence sensitization immune responses.

Language: Английский

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