Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)
Published: Feb. 21, 2024
Photon-controlled pyroptosis activation (PhotoPyro) is a promising technique for cancer immunotherapy due to its noninvasive nature, precise control, and ease of operation. Here, we report that biomolecular photoredox catalysis in cells might be an important mechanism underlying PhotoPyro. Our findings reveal the photocatalyst lutetium texaphyrin (
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 798 - 811
Published: Jan. 25, 2024
Language: Английский
Citations
29
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986
Published: June 2, 2024
Language: Английский
Citations
29
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215863 - 215863
Published: April 5, 2024
Language: Английский
Citations
21
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: June 10, 2024
Abstract The development of Type I photosensitizers (PSs) is great importance due to the inherent hypoxic intolerance photodynamic therapy (PDT) in microenvironment. Compared II PSs, PSs are less reported absence a general molecular design strategy. Herein, we report that combination typical PS and natural substrate carvacrol (CA) can significantly facilitate pathway efficiently generate superoxide radical (O 2 –• ). Detailed mechanism study suggests CA activated into thymoquinone (TQ) by local singlet oxygen generated from upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes conversion O via transfer-based pathway. Notably, three classical employed demonstrate universality proposed approach. PDT against S. aureus has been demonstrated under conditions vitro. Furthermore, this coupled agent exhibits significant bactericidal activity with antibacterial rate 99.6% for bacterial-infection female mice vivo experiments. Here, show simple, effective, universal method endow traditional tolerance.
Language: Английский
Citations
21
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215720 - 215720
Published: Feb. 16, 2024
Language: Английский
Citations
20
Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107150 - 107150
Published: March 21, 2024
Cancer, with its diversity, heterogeneity, and complexity, is a significant contributor to global morbidity, disability, mortality, highlighting the necessity for transformative treatment approaches. Photodynamic therapy (PDT) has aroused continuous interest as viable alternative conventional cancer treatments that encounter drug resistance. Nanotechnology brought new advances in medicine shown great potential delivery treatment. For precise efficient therapeutic utilization of such tumor approach high spatiotemporal selectivity minimal invasiveness, carrier-free noncovalent nanoparticles (NPs) based on chemo-photodynamic combination essential. Utilizing natural products foundation nanodrug development offers unparalleled advantages, including exceptional pharmacological activity, easy functionalization/modification, well biocompatibility. The natural-product-based, carrier-free, NPs revealed excellent synergistic anticancer activity comparison free photosensitizers bioactive products, representing an favorable avenue improve efficacy. Herein, comprehensive summary current strategies representative application examples past decade (such paclitaxel, 10-hydroxycamptothecin, doxorubicin, etoposide, combretastatin A4, epigallocatechin gallate, curcumin) therapy. We highlight insightful design synthesis smart aim enhance PDT Meanwhile, we discuss future challenges opportunities associated these provide enlightenment, spur innovative ideas, facilitate PDT-mediated clinical transformation.
Language: Английский
Citations
19
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Biofilm-induced chronic bacterial infections represent a significant challenge in modern medicine due to their resistance conventional antibiotic treatments. Although photodynamic therapy (PDT) has emerged as promising antibiotic-free antibacterial strategy, the hypoxic condition within biofilms and lack of an effective local drug delivery system have limited clinical effectiveness photosensitizer (PS) agents. Herein, we propose type charge regulation-enhanced I PS-loaded hydrogel dressing for treating biofilm infection. The regulation enables multiple alkylation Nile blue (EB series) exhibit substantially improved absorbance (∼2-fold), alkaline tolerance, superoxide anion yield (2.2-4.2-fold) compared representative PS, sulfur-substituted blue. Specifically, enhanced electronic push-pull capabilities promote more efficient electron recycling process, significantly boosting efficiency PDT. superior PDT effect uptake via render EB series pronounced inhibition under red light or sunlight irradiation. Moreover, hydrogel, constructed from oxidized dextran quaternized chitosan, facilitates localization sustained retention PSs, accelerating healing biofilm-infected wounds. This PS-based could provide user-friendly wound treatment prevention infections.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
Abstract Photodynamic therapy (PDT) holds significant promise for antibacterial treatment, with its potential markedly amplified when using Type I photosensitizers (PSs). However, developing PSs remains a challenge due to lack of reliable design strategy. Herein, PS nanocluster is developed via self‐assembly zwitterionic small molecule (C3TH) superior PDT in vivo. Mechanism studies demonstrate that unique cross‐arranged C3TH within not only shortens intermolecular distance but also inhibits electronic‐vibrational coupling, thus facilitating photoinduced electron transfer form radical cation and anion autoionization reaction. Subsequently, these highly oxidizing or reducing radicals engage cascade photoredox generate efficient ·OH O 2 ‾·. As result, nanoclusters achieve 97.6% efficacy against MRSA at an ultralow dose, surpassing the commercial antibiotic Vancomycin by more than 8.8‐fold. These findings deepen understanding PDT, providing novel strategy PSs.
Language: Английский
Citations
3
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)
Published: March 1, 2023
Type I photodynamic therapy (PDT) represents a promising treatment modality for tumors with intrinsic hypoxia. However, type photosensitizers (PSs), especially ones near infrared (NIR) absorption, are limited and their efficacy needs improvement via new targeting tactics. We develop NIR PS by engineering acridinium derived donor-π-acceptor systems. The exhibits an exclusive PDT mechanism due to effective intersystem crossing disfavored energy transfer O2 , shows selective binding G-quadruplexes (G4s) hydrogen bonds identified molecular docking study. Moreover, it enables fluorogenic detection of G4s efficient ⋅- production in hypoxic conditions, leading immunogenic cell death substantial variations gene expression RNA sequencing. Our strategy demonstrates augmented antitumor immunity ablation cold tumor, highlighting its potential RNA-targeted precision cancer therapy.
Language: Английский
Citations
44
Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)
Published: April 28, 2023
Near-infrared fluorescence imaging is vital for exploring the biological world. The short emissions (<650 nm) and small Stokes shifts (<30 of current xanthene dyes obstruct their applications since a long time. Recently, potent universal THQ structural modification technique that emission to NIR-I/II range enables substantial shift (>100 THQ-modified established. Thus, timely discussion THQ-xanthene its extensive. Hence, advent, working principles, development trajectory, dyes, especially in fields probe-based sensing imaging, cancer theranostics, super-resolution are introduced. It envisioned tactic simple yet exceptional approach upgrade performance conventional dyes. will advance strides xanthene-based potentials early fluorescent diagnosis diseases, imaging-guided surgery.
Language: Английский
Citations
40