Recent Developments in PET and SPECT Radiotracers as Radiopharmaceuticals for Hypoxia Tumors DOI Creative Commons
Thu Anh Nguyen, Hee‐Kwon Kim

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1840 - 1840

Published: June 27, 2023

Hypoxia, a deficiency in the levels of oxygen, is common feature most solid tumors and induces many characteristics cancer. Hypoxia associated with metastases strong resistance to radio- chemotherapy, can decrease accuracy cancer prognosis. Non-invasive imaging methods such as positron emission tomography (PET) single-photon computed (SPECT) using hypoxia-targeting radiopharmaceuticals have been used for detection therapy tumor hypoxia. Nitroimidazoles are bioreducible moieties that be selectively reduced under hypoxic conditions covalently bind intracellular macromolecules, trapped within cells tissues. Recently, there has motivation develop PET SPECT radiotracers containing nitroimidazole visualization treatment tumors. In this review, we summarize development some novel nitroimidazoles, well their physicochemical properties, vitro cellular uptake values, vivo biodistribution, PET/SPECT results.

Language: Английский

Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy DOI
Sisi Wang, Lizhi Gai, Yuncong Chen

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3976 - 4019

Published: Jan. 1, 2024

This review focuses on the design strategy, spectroscopic characteristics, and functionalization of mitochondrion-targeted BODIPY dyes, providing an overview these dyes for bioimaging photodynamic therapy.

Language: Английский

Citations

63

A more flexible long-chain bis(salamo)-like fluorescent probe based on FRET and ICT effects for the identification of aluminum ion in the environment and plants DOI Open Access
Xiaoxia Li,

Ming‐Xia Du,

Chen‐Yin Ma

et al.

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1295, P. 136792 - 136792

Published: Oct. 5, 2023

Language: Английский

Citations

60

Near‐Infrared Luminescent Materials Incorporating Rare Earth/Transition Metal Ions: From Materials to Applications DOI

Hua‐Hui Li,

Ya‐Kun Wang, Liang‐Sheng Liao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(30)

Published: May 11, 2024

Abstract The spotlight has shifted to near‐infrared (NIR) luminescent materials emitting beyond 1000 nm, with growing interest due their unique characteristics. ability of NIR‐II emission (1000–1700 nm) penetrate deeply and transmit independently positions these NIR for applications in optical‐communication devices, bioimaging, photodetectors. combination rare earth metals/transition metals a variety matrix provides new platform creating chemical physical properties science device applications. In this review, the recent advancements activated by transition metal ions are summarized role spanning sensing, optoelectronics is illustrated. It started various synthesis techniques explored how earths/transition can be skillfully incorporated into matrixes, thereby endowing them discussion strategies enhancing excitation absorption efficiency, spotlighting innovations like dye sensitization surface plasmon resonance effects then extended. Subsequently, significant focus placed on functionalization Finally, comprehensive analysis challenges proposed earth/transition ion‐doped materials, summarizing insights each section provided.

Language: Английский

Citations

52

MOF-derived porous carbon nanozyme-based flexible electrochemical sensing system for in situ and real-time monitoring of H2O2 released from cells DOI
Xiao Wang, Yanan Wang,

Yali Liu

et al.

Talanta, Journal Year: 2023, Volume and Issue: 266, P. 125132 - 125132

Published: Aug. 28, 2023

Language: Английский

Citations

36

Mitochondria-targetable small molecule fluorescent probes for the detection of cancer-associated biomarkers: A review DOI
Xue Yu, Yunong Huang,

Yunqi Tao

et al.

Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1289, P. 342060 - 342060

Published: Nov. 25, 2023

Language: Английский

Citations

32

Responsive fluorescent probes for cellular microenvironment and redox small biomolecules DOI
Li Zhang, Liangwei Zhang, Xia Zhang

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 169, P. 117377 - 117377

Published: Oct. 19, 2023

Language: Английский

Citations

30

Tunable Nanoparticles with Aggregation‐Induced Emission Heater for Precise Synergistic Photothermal and Thermodynamic Oral Cancer Therapy of Patient‐Derived Tumor Xenograft DOI Creative Commons
Leitao Zhang, Chengyan Chu,

Xuefeng Lin

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(17)

Published: April 20, 2023

The fluorophores in the second near-infrared (NIR-II) biological window (1000 - 1700 nm) show great application prospects fields of biology and optical communications. However, both excellent radiative transition nonradiative cannot be achieved simultaneously for majority traditional fluorophores. Herein, tunable nanoparticles formulated with aggregation-induced emission (AIE) heater are developed rationally. system can implemented via development an ideal synergistic that not only produce photothermal from nonspecific triggers but also trigger carbon radical release. Once accumulating tumors subsequently being irradiated 808 nm laser, (NMB@NPs) encapsulated NMDPA-MT-BBTD (NMB) splitted due to effect NMB, leading decomposition azo bonds nanoparticle matrix generate radical. Accompanied by fluorescence image-guided thermodynamic therapy (TDT) (PTT) which significantly inhibited growth oral cancer negligible systemic toxicity is synergistically. Taken together, this AIE luminogens-based photothermal-thermodynamic strategy brings a new insight into design superior versatile fluorescent NPs precise biomedical applications holds promise enhance therapeutic efficacy therapy.

Language: Английский

Citations

28

Metal–Phenolic‐Mediated Assembly of Functional Small Molecules into Nanoparticles: Assembly and Bioapplications DOI Creative Commons
Jingqu Chen, Christina Cortez‐Jugo, Chan‐Jin Kim

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 29, 2024

Abstract Small molecules, including therapeutic drugs and tracer play a vital role in biological processing, disease treatment diagnosis, have inspired various nanobiotechnology approaches to realize their function, particularly drug delivery. Desirable features of delivery system for functional small molecules (FSMs) include high biocompatibility, loading capacity, simple manufacturing processes, without the need chemical modification FSM itself. Herein, we report versatile approach, based on metal–phenolic‐mediated assembly, assembling FSMs into nanoparticles (i.e., FSM‐MPN NPs) under aqueous ambient conditions. We demonstrate anticancer drugs, latency reversal agents, fluorophores at up ~80 % that is mostly facilitated by π hydrophobic interactions between nanoparticle components. Secondary engineering involving coating with polyphenol–antibody thin film or sequential co‐loading multiple enables cancer cell targeting combination delivery, respectively. Incorporating NPs visualization biodistribution different time points, revealing most these are retained kidney heart 24 h post intravenous administration. This work provides viable pathway rational design molecule platforms diverse applications.

Language: Английский

Citations

15

Electrophilicity Modulation for Sub‐ppm Visualization and Discrimination of EDA DOI Creative Commons
Hao Zhao, Yuan Liu, Gaosheng Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)

Published: March 6, 2024

Abstract Precise and timely recognition of hazardous chemical substances is great significance for safeguarding human health, ecological environment, public security, etc., especially crucial adopting appropriate disposition measures. Up to now, there remains a practical challenge sensitively detect differentiate organic amines with similar structures intuitive analysis outcomes. Here, unique optical probe two electrophilic sites rapid ultra‐sensitive ratiometric fluorescence detection ethylenediamine (EDA) presented, while producing distinct signals its structural analog. The exhibits ppb/nmol level sensitivity liquidous gaseous EDA, specific toward EDA without disturbance up 28 potential interferents, as well response within 0.2 s. By further combining the portable sensing chip convolutional algorithm endowed image processing, this work cracked problem precisely discriminating target non‐targets at extremely low concentrations.

Language: Английский

Citations

13

Small Molecular Fluorescent Probes for Alzheimer's Disease Associated Active Species DOI

Fuyan Tang,

Kai Wang, Xueli Liu

et al.

Chemistry - A European Journal, Journal Year: 2023, Volume and Issue: 29(35)

Published: April 20, 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the main cause of dementia worldwide. As pathogenesis AD quite complicated, there continuous attention to AD-associated active species, such as amyloid-β plaques, neurofibrillary tangles, metal ions, reactive oxygen/nitrogen/sulphur cholinesterase, viscosity, formaldehyde so on. To this end, series small molecular fluorescent probes for these species have been explored early diagnosis even remedy AD. Herein, we systematacially summarize versatile mainly in recent three years, including relationship between structure properties well targeted imaging application all probes. Moreover, challenges perspectives AD-related are briefly explicated. We firmly expect review may provide guidance constructing new AD-relevant promote clinical study

Language: Английский

Citations

19