Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1840 - 1840
Published: June 27, 2023
Hypoxia,
a
deficiency
in
the
levels
of
oxygen,
is
common
feature
most
solid
tumors
and
induces
many
characteristics
cancer.
Hypoxia
associated
with
metastases
strong
resistance
to
radio-
chemotherapy,
can
decrease
accuracy
cancer
prognosis.
Non-invasive
imaging
methods
such
as
positron
emission
tomography
(PET)
single-photon
computed
(SPECT)
using
hypoxia-targeting
radiopharmaceuticals
have
been
used
for
detection
therapy
tumor
hypoxia.
Nitroimidazoles
are
bioreducible
moieties
that
be
selectively
reduced
under
hypoxic
conditions
covalently
bind
intracellular
macromolecules,
trapped
within
cells
tissues.
Recently,
there
has
motivation
develop
PET
SPECT
radiotracers
containing
nitroimidazole
visualization
treatment
tumors.
In
this
review,
we
summarize
development
some
novel
nitroimidazoles,
well
their
physicochemical
properties,
vitro
cellular
uptake
values,
vivo
biodistribution,
PET/SPECT
results.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 3976 - 4019
Published: Jan. 1, 2024
This
review
focuses
on
the
design
strategy,
spectroscopic
characteristics,
and
functionalization
of
mitochondrion-targeted
BODIPY
dyes,
providing
an
overview
these
dyes
for
bioimaging
photodynamic
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 11, 2024
Abstract
The
spotlight
has
shifted
to
near‐infrared
(NIR)
luminescent
materials
emitting
beyond
1000
nm,
with
growing
interest
due
their
unique
characteristics.
ability
of
NIR‐II
emission
(1000–1700
nm)
penetrate
deeply
and
transmit
independently
positions
these
NIR
for
applications
in
optical‐communication
devices,
bioimaging,
photodetectors.
combination
rare
earth
metals/transition
metals
a
variety
matrix
provides
new
platform
creating
chemical
physical
properties
science
device
applications.
In
this
review,
the
recent
advancements
activated
by
transition
metal
ions
are
summarized
role
spanning
sensing,
optoelectronics
is
illustrated.
It
started
various
synthesis
techniques
explored
how
earths/transition
can
be
skillfully
incorporated
into
matrixes,
thereby
endowing
them
discussion
strategies
enhancing
excitation
absorption
efficiency,
spotlighting
innovations
like
dye
sensitization
surface
plasmon
resonance
effects
then
extended.
Subsequently,
significant
focus
placed
on
functionalization
Finally,
comprehensive
analysis
challenges
proposed
earth/transition
ion‐doped
materials,
summarizing
insights
each
section
provided.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(17)
Published: April 20, 2023
The
fluorophores
in
the
second
near-infrared
(NIR-II)
biological
window
(1000
-
1700
nm)
show
great
application
prospects
fields
of
biology
and
optical
communications.
However,
both
excellent
radiative
transition
nonradiative
cannot
be
achieved
simultaneously
for
majority
traditional
fluorophores.
Herein,
tunable
nanoparticles
formulated
with
aggregation-induced
emission
(AIE)
heater
are
developed
rationally.
system
can
implemented
via
development
an
ideal
synergistic
that
not
only
produce
photothermal
from
nonspecific
triggers
but
also
trigger
carbon
radical
release.
Once
accumulating
tumors
subsequently
being
irradiated
808
nm
laser,
(NMB@NPs)
encapsulated
NMDPA-MT-BBTD
(NMB)
splitted
due
to
effect
NMB,
leading
decomposition
azo
bonds
nanoparticle
matrix
generate
radical.
Accompanied
by
fluorescence
image-guided
thermodynamic
therapy
(TDT)
(PTT)
which
significantly
inhibited
growth
oral
cancer
negligible
systemic
toxicity
is
synergistically.
Taken
together,
this
AIE
luminogens-based
photothermal-thermodynamic
strategy
brings
a
new
insight
into
design
superior
versatile
fluorescent
NPs
precise
biomedical
applications
holds
promise
enhance
therapeutic
efficacy
therapy.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(12)
Published: Jan. 29, 2024
Abstract
Small
molecules,
including
therapeutic
drugs
and
tracer
play
a
vital
role
in
biological
processing,
disease
treatment
diagnosis,
have
inspired
various
nanobiotechnology
approaches
to
realize
their
function,
particularly
drug
delivery.
Desirable
features
of
delivery
system
for
functional
small
molecules
(FSMs)
include
high
biocompatibility,
loading
capacity,
simple
manufacturing
processes,
without
the
need
chemical
modification
FSM
itself.
Herein,
we
report
versatile
approach,
based
on
metal–phenolic‐mediated
assembly,
assembling
FSMs
into
nanoparticles
(i.e.,
FSM‐MPN
NPs)
under
aqueous
ambient
conditions.
We
demonstrate
anticancer
drugs,
latency
reversal
agents,
fluorophores
at
up
~80
%
that
is
mostly
facilitated
by
π
hydrophobic
interactions
between
nanoparticle
components.
Secondary
engineering
involving
coating
with
polyphenol–antibody
thin
film
or
sequential
co‐loading
multiple
enables
cancer
cell
targeting
combination
delivery,
respectively.
Incorporating
NPs
visualization
biodistribution
different
time
points,
revealing
most
these
are
retained
kidney
heart
24
h
post
intravenous
administration.
This
work
provides
viable
pathway
rational
design
molecule
platforms
diverse
applications.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(18)
Published: March 6, 2024
Abstract
Precise
and
timely
recognition
of
hazardous
chemical
substances
is
great
significance
for
safeguarding
human
health,
ecological
environment,
public
security,
etc.,
especially
crucial
adopting
appropriate
disposition
measures.
Up
to
now,
there
remains
a
practical
challenge
sensitively
detect
differentiate
organic
amines
with
similar
structures
intuitive
analysis
outcomes.
Here,
unique
optical
probe
two
electrophilic
sites
rapid
ultra‐sensitive
ratiometric
fluorescence
detection
ethylenediamine
(EDA)
presented,
while
producing
distinct
signals
its
structural
analog.
The
exhibits
ppb/nmol
level
sensitivity
liquidous
gaseous
EDA,
specific
toward
EDA
without
disturbance
up
28
potential
interferents,
as
well
response
within
0.2
s.
By
further
combining
the
portable
sensing
chip
convolutional
algorithm
endowed
image
processing,
this
work
cracked
problem
precisely
discriminating
target
non‐targets
at
extremely
low
concentrations.
Chemistry - A European Journal,
Journal Year:
2023,
Volume and Issue:
29(35)
Published: April 20, 2023
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
and
the
main
cause
of
dementia
worldwide.
As
pathogenesis
AD
quite
complicated,
there
continuous
attention
to
AD-associated
active
species,
such
as
amyloid-β
plaques,
neurofibrillary
tangles,
metal
ions,
reactive
oxygen/nitrogen/sulphur
cholinesterase,
viscosity,
formaldehyde
so
on.
To
this
end,
series
small
molecular
fluorescent
probes
for
these
species
have
been
explored
early
diagnosis
even
remedy
AD.
Herein,
we
systematacially
summarize
versatile
mainly
in
recent
three
years,
including
relationship
between
structure
properties
well
targeted
imaging
application
all
probes.
Moreover,
challenges
perspectives
AD-related
are
briefly
explicated.
We
firmly
expect
review
may
provide
guidance
constructing
new
AD-relevant
promote
clinical
study
