Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(28), P. 33584 - 33599

Published: July 9, 2021

Stimuli-responsive hydrogels possess unique advantages in drug delivery due to their variable performance and status based on the external environment. In present study, a dual-responsive (pH reactive oxygen species (ROS)) hydrogel was prepared realize release properties under inflammatory stimulation. By grafting 3-carboxy-phenylboronic acid gelatin molecular backbone cross-linking with poly(vinyl alcohol), we successfully synthesized inflammation-responsive drug-loaded after encapsulation vancomycin-conjugated silver nanoclusters (VAN-AgNCs) pH-sensitive micelles loaded nimesulide (NIM). This novel design not only retained dynamic functions of hydrogels, such as injectability, self-healing, remodeling, but also realized sequential on-demand at diabetic-infected wound sites. this work, found that exhibited excellent biocompatibility hemostasis owing enhanced cell-adhesive property component. The significant antibacterial anti-inflammatory effect demonstrated an vitro experiment. Moreover, vivo experiment, play role promoting infected healing through processes. Collectively, containing VAN-AgNCs NIM-loaded has great potential application chronically diabetic treatment, well other diseases.

Language: Английский

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A spatiotemporal release platform based on pH/ROS stimuli-responsive hydrogel in wound repairing

Journal of Controlled Release, Journal Year: 2021, Volume and Issue: 341, P. 147 - 165

Published: Nov. 20, 2021

Language: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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Dual-responsive injectable hydrogels encapsulating drug-loaded micelles for on-demand antimicrobial activity and accelerated wound healing

Journal of Controlled Release, Journal Year: 2020, Volume and Issue: 324, P. 204 - 217

Published: May 7, 2020

Language: Английский

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Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases

Journal of Medicinal Chemistry, Journal Year: 2020, Volume and Issue: 64(1), P. 298 - 325

Published: Dec. 23, 2020

Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a variety diseases, including cancer, inflammation, and neurodegenerative diseases. In light significant differences ROS between the nonpathogenic pathological tissues, an increasing number ROS-responsive prodrugs, probes, theranostic prodrugs developed for targeted treatment precise diagnosis ROS-related This review will summarize provide insight into recent advances fluorescent with applications to different diseases various subcellular organelle-targetable disease-targetable features. The moieties, self-immolative linkers, typical activation mechanism release are also summarized discussed.

Language: Английский

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Recent advances on endogenous/exogenous stimuli-triggered nanoplatforms for enhanced chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 451, P. 214267 - 214267

Published: Nov. 6, 2021

Language: Английский

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A Dual‐Responsive Antibiotic‐Loaded Nanoparticle Specifically Binds Pathogens and Overcomes Antimicrobial‐Resistant Infections

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(9)

Published: Jan. 22, 2021

Antimicrobial resistant (AMR) infections are a growing threat to public health and there is general lack of development in new antibiotics. Here, dextran-coated stimuli-responsive nanoparticle (NP) that encapsulates the hydrophobic antibiotic, rifampicin, specifically binds bacteria overcome AMR reported. The NP shows strong affinity with variety pathogens vitro effectively accumulates bacterial infected tissues. activated by either low pH or high reactive oxygen species infectious microenvironment, releases both cationic polymer rifampicin display synergistic activity against pathogens. carrier also enables antibiotic penetrate biofilms mammalian cells, thus allowing elimination biofilm intracellular infections. formulation demonstrates safety efficacy two animal infection models Gram-negative Gram-positive

Language: Английский

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Responsive hydrogel dressings for intelligent wound management

BMEMat, Journal Year: 2023, Volume and Issue: 1(2)

Published: April 15, 2023

Abstract Due to global aging problems, the rising number of patients suffering from chronic or hard‐to‐heal acute wounds imposes a significant burden on healthcare systems. Wound healing is complicated and dynamic physiological process with distinct molecular cellular levels at each phase. Despite numerous strategies advanced wound dressings being developed, successful management through smart dressing materials that can adapt changing microenvironments address needs different stages remains big challenge. Over last decade, hydrogel‐based have emerged as one most potent biomaterials for treatment favorable biological characteristics high potential active intervention during wound‐curing process. In current contribution, we present recent progress in hydrogel regulate release therapeutics response external stimuli (such light) well endogenous changes environments (e.g., temperature, pH, glucose, reactive oxygen species) facilitate healing. We also introduce cutting‐edge technologies intelligent “sense‐and‐treat” combination built‐in sensors sensing molecules responsive hydrogels, which enable real‐time monitoring conditions prompt on‐demand therapy.

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(2), P. 184 - 192

Published: Jan. 26, 2023

Language: Английский

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