High‐Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on β‐Lapachone‐Triggered ROS Amplification Specific in Cancer Cells

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(23), P. 12992 - 12998

Published: March 27, 2021

Abstract Discrimination of cancer cells/tissues from normal ones is critical importance for early diagnosis and treatment cancers. Herein, we present a new strategy high‐contrast fluorescence based on β‐Lapachone (β‐Lap, an anticancer agent) triggered ROS (reactive oxygen species) amplification specific in cells/tissues. With the strategy, wide range cells/tissues, including surgical tissue specimens harvested patients, were distinguished by using combination β‐Lap Si‐rhodamine‐based NIR fluorescent probe PSiR3 developed this work with average tumor‐to‐normal (T/N) ratios up to 15 cell level 24 level, far exceeding clinically acceptable threshold 2.0. What's more, allowed discrimination tumor tissues inflammatory whether marked enhancement could be induced when treated β‐Lap/ combination, respectively.

Language: Английский

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Engineering a theranostic platform for synergistic hypoxia-responsive photodynamic therapy and chemotherapy

Matter, Journal Year: 2022, Volume and Issue: 5(5), P. 1502 - 1519

Published: March 11, 2022

Language: Английский

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THQ–Xanthene: An Emerging Strategy to Create Next‐Generation NIR‐I/II Fluorophores

Advanced Science, Journal Year: 2023, Volume and Issue: 10(18)

Published: April 28, 2023

Near-infrared fluorescence imaging is vital for exploring the biological world. The short emissions (<650 nm) and small Stokes shifts (<30 of current xanthene dyes obstruct their applications since a long time. Recently, potent universal THQ structural modification technique that emission to NIR-I/II range enables substantial shift (>100 THQ-modified established. Thus, timely discussion THQ-xanthene its extensive. Hence, advent, working principles, development trajectory, dyes, especially in fields probe-based sensing imaging, cancer theranostics, super-resolution are introduced. It envisioned tactic simple yet exceptional approach upgrade performance conventional dyes. will advance strides xanthene-based potentials early fluorescent diagnosis diseases, imaging-guided surgery.

Language: Английский

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Small molecule fluorescent probes for the detection of reactive nitrogen species in biological systems

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 493, P. 215258 - 215258

Published: June 15, 2023

Language: Английский

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Recent progress of near-infrared fluorescent probes in the determination of reactive oxygen species for disease diagnosis

Talanta, Journal Year: 2023, Volume and Issue: 268, P. 125264 - 125264

Published: Oct. 11, 2023

Language: Английский

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Mercury(II)-Triggered Targeted and NIR-II Fluorescence/Photoacoustic Imaging Probe for High-Sensitivity Early Diagnosis and Evaluating Drug against Acute Liver and Kidney Injury

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Mercury ions (Hg2+) have been found to disrupt the body's antioxidant defense mechanisms, leading oxidative stress and physiological dysfunction. Early diagnosis real-time monitoring of Hg2+ fluctuations in organ damage are crucial but limited due lack noninvasive deep tissue imaging probes. Herein, a Hg2+-triggered targeted NIR-II fluorescence/photoacoustic (PA) dual-mode molecular probe (NHG-2) was developed for Hg2+-induced acute liver kidney injury mice. NHG-2 designed through rational adjustment conjugated ring structure further screening processes, enabling it sensitively recognize subsequently open mitochondrial targeting, producing fluorescence/PA signals. This allowed injury, demonstrating excellent detection sensitivity. Furthermore, can be utilized evaluate efficacy N-acetylcysteine (NAC) dual signal indication. Mechanism studies suggested that NAC activated Akt/Nrf2 signaling pathway, reversed changes related biomarkers, restored membrane potential. Thus, this study not only presents first specific also provides potential tool early treatment evaluation pathogenesis study.

Language: Английский

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Xanthene-Based NIR organic phototheranostics agents: Design strategies and biomedical applications

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Near-infrared fluorescence imaging is key in biological exploration. Short emission wavelengths of xanthene dyes limit their use. Structural modifications shift emissions to the NIR-I/II range, enhancing biomedical applications.

Language: Английский

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Discrimination between cancerous and normal cells/tissues enabled by a near-infrared fluorescent HClO probe

Sensors and Actuators B Chemical, Journal Year: 2021, Volume and Issue: 334, P. 129602 - 129602

Published: Feb. 9, 2021

Language: Английский

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Self-Targeting Carbon Quantum Dots for Peroxynitrite Detection and Imaging in Live Cells

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(49), P. 16466 - 16473

Published: Dec. 3, 2021

Peroxynitrite (ONOO–), a highly reactive nitrogen species (RNS) generated mainly in mitochondria, has been identified to be associated with numerous pathophysiological processes, and thus accurate ONOO– imaging superior sensitivity selectivity is desirable. Herein, we prepared new type of carbon quantum dots (CQDs) mitochondria-targeting function without the aid any targeting molecules via simple one-step hydrothermal route. The as-prepared CQDs not only displayed relatively uniform size distribution, few surface defects, high photostability, excellent biocompatibility but also exhibited good selective fluorescence turn-off response toward ONOO–, owing oxidation amino groups on dots. A great linear correlation between quenching efficiency concentration range from 0.15 1.0 μM detection limit 38.9 nM shown. Moreover, acting as functional optical probe through self-targeting mechanism were successfully applied for situ visualization endogenous mitochondria live cells, providing promise elucidating complex biological roles related pathological processes.

Language: Английский

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Targeted Imaging in Atherosclerosis

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(36), P. 12263 - 12273

Published: Aug. 30, 2022

Atherosclerosis is a chronic inflammatory disease involved in plaque rupture, stroke, thrombosis, and heart attack (myocardial infarction), which leading cause of sudden cardiovascular events. In the past decades, various imaging strategies have been designed employed for diagnosis atherosclerosis. Targeted can accurately distinguish pathological tissues from normal reliably reveal biological information occurrence development By taking advantage versatile techniques, rationally probes targeting biomarkers overexpressed microenvironments activated cells by modifying specific ligands accumulated lesion regions attracted increasing attention. This Perspective elucidates comprehensively targeted strategies, current challenges, future directions precise identification atherosclerosis, beneficial to better understand physiological progression exploit novel strategies.

Language: Английский

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