Activatable Two-Photon Near-Infrared Fluorescent Probe Tailored toward Peroxynitrite In Vivo Imaging in Tumors

Analytical Chemistry, Journal Year: 2020, Volume and Issue: 92(19), P. 13305 - 13312

Published: Sept. 10, 2020

A malignant tumor remains one of the leading causes deaths across world. Thus, diagnosis development with noninvasive visualizing methods is significant for therapy. Herein, an activatable two-photon NIR fluorescent probe DHQ-Rd-PN in vivo imaging peroxynitrite a was elaborately designed. The demonstrated increased emission response to vitro, which ensured that detects ONOO– cell and vivo. Cellular results disclosed competent detect adscititious level change HeLa cells, as well endogenous concentration lipopolysaccharides (LPS) IFN-γ-stimulated RAW 264.7 cells. Additionally, zebrafish revealed accumulated pancreas lightened up by addition ONOO–. Remarkably, can be harnessed image production profile xenograft 4T1 mice both one-photon fluorescence imaging. Benefiting excitable properties emissive properties, used onset tumors first time. This work provided efficient detection method tumor, would find more applications therapies.

Language: Английский

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Turning waste into wealth: facile and green synthesis of carbon nanodots from pollutants and applications to bioimaging

Chemical Science, Journal Year: 2021, Volume and Issue: 12(35), P. 11722 - 11729

Published: Jan. 1, 2021

The pollutant reactive red 2 was employed to synthesize fluorescent carbon nanodots allowing biological imaging in vitro and vivo .

Language: Английский

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Experimental Models of Hepatocellular Carcinoma—A Preclinical Perspective

Cancers, Journal Year: 2021, Volume and Issue: 13(15), P. 3651 - 3651

Published: July 21, 2021

Hepatocellular carcinoma (HCC), the most frequent form of primary liver carcinoma, is a heterogenous and complex tumor type with increased incidence, poor prognosis, high mortality. The actual therapeutic arsenal narrow poorly effective, rendering this disease global health concern. Although considerable progress has been made in terms understanding pathogenesis, molecular mechanisms, genetics, therapeutical approaches, several facets human HCC remain undiscovered. A valuable prompt approach to acquire further knowledge about unrevealed aspects novel candidates represented by application experimental models. Experimental models (in vivo vitro 2D 3D models) are considered reliable tools gather data for clinical usability. This review offers an overview currently available preclinical frequently applied study hepatocellular initiation, development, progression, as well discovery efficient treatments, highlighting advantages limitations each model. Furthermore, we also focus on role played computational studies silico artificial intelligence-based prediction promising cancer research.

Language: Английский

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Nanoparticle entry into cells; the cell biology weak link

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114403 - 114403

Published: June 29, 2022

Language: Английский

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Research in the Field of Drug Design and Development

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(9), P. 1283 - 1283

Published: Sept. 11, 2023

The processes used by academic and industrial scientists to discover new drugs have recently experienced a true renaissance, with many exciting techniques being developed over the past 5-10 years alone. Drug design discovery, search for safe well-tolerated compounds, as well ineffectiveness of existing therapies, society's insufficient knowledge concerning prophylactics pharmacotherapy most common diseases today, comprise serious challenge. This can influence not only quality human life, but also health whole societies, which became evident during COVID-19 pandemic. In general, process drug development consists three main stages: preclinical using cell-based animal models/tests, clinical trials on humans and, finally, forward moving toward step obtaining regulatory approval, in order market potential drug. this review, we will attempt outline first important consecutive phases development, based experience cooperating complementary centers Visegrád group; i.e., Medical University Lublin, Poland, Masaryk Brno, Czech Republic, Comenius Bratislava, Slovak Republic.

Language: Английский

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Unveiling the Impact of Dyes on Aquatic Ecosystems through Zebrafish – A Comprehensive Review

Environmental Research, Journal Year: 2024, Volume and Issue: 261, P. 119684 - 119684

Published: July 26, 2024

Language: Английский

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Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1926 - 1926

Published: Feb. 5, 2024

Nanomaterials are widely used in various fields, and ongoing research is focused on developing safe sustainable nanomaterials. Using zebrafish as a model organism for studying the potentially toxic effects of nanomaterials highlights importance Studies conducted their toxicity potential risks to human environmental health vital biomedical sciences. In present review, we discuss (inorganic organic) exposure based size, shape, concentration. The review further explores types impacts at different levels, indicating that can lead developmental defects, changes gene expressions, toxicities. also covers considering natural organic matter chorion membranes standardized nanotoxicity testing. While some biologically compatible, metal semiconductor enter water environment increase aquatic creatures accumulate body. Further investigations necessary assess safety health.

Language: Английский

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Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae

NanoImpact, Journal Year: 2025, Volume and Issue: unknown, P. 100549 - 100549

Published: Feb. 1, 2025

Language: Английский

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Generic physiologically-based toxicokinetic modelling for fish: Integration of environmental factors and species variability

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 651, P. 516 - 531

Published: Sept. 16, 2018

Language: Английский

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Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology

Journal of the Association for Research in Otolaryngology, Journal Year: 2019, Volume and Issue: 20(1), P. 1 - 19

Published: Jan. 11, 2019

Language: Английский

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