Green
chemistry
has
been
a
growing
multidisciplinary
field
in
recent
years
showing
great
promise
biomedical
applications,
especially
for
cancer
therapy.
Chitosan
(CS)
is
an
abundant
biopolymer
derived
from
chitin
and
present
insects
fungi.
This
polysaccharide
favorable
characteristics,
including
biocompatibility,
biodegradability,
ease
of
modification
by
enzymes
chemicals.
CS-based
nanoparticles
(CS-NPs)
have
shown
potential
the
treatment
other
diseases,
affording
targeted
delivery
overcoming
drug
resistance.
The
current
review
emphasizes
on
application
CS-NPs
chemotherapeutic
agent,
doxorubicin
(DOX),
therapy
as
they
promote
internalization
DOX
cells
prevent
activity
P-glycoprotein
(P-gp)
to
reverse
These
nanoarchitectures
can
provide
co-delivery
with
antitumor
agents
such
curcumin
cisplatin
induce
synergistic
Furthermore,
co-loading
siRNA,
shRNA,
miRNA
suppress
tumor
progression
chemosensitivity.
Various
nanostructures,
lipid-,
carbon-,
polymeric-
metal-based
nanoparticles,
are
modifiable
CS
delivery,
while
functionalization
ligands
hyaluronic
acid
promotes
selectivity
toward
prevents
demonstrate
high
encapsulation
efficiency
due
protonation
amine
groups
CS,
pH-sensitive
release
occur.
redox-
light-responsive
prepared
treatment.
Leveraging
these
characteristics
view
biocompatibility
CS-NPs,
we
expect
soon
see
significant
progress
towards
clinical
translation.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 9, 2023
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Chemical Society Reviews,
Journal Year:
2020,
Volume and Issue:
50(3), P. 1480 - 1494
Published: Dec. 21, 2020
A
tutorial
review
showcasing
how
peptide–drug
conjugates
can
offer
the
versatility
needed
for
a
successful
drug
discovery
approach,
their
problems
and
future
opportunities.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(3), P. 4162 - 4174
Published: March 1, 2022
Tumor
hypoxia
seriously
impairs
the
therapeutic
outcomes
of
type
II
photodynamic
therapy
(PDT),
which
is
highly
dependent
upon
tissue
oxygen
concentration.
Herein,
a
facile
strategy
acceptor
planarization
and
donor
rotation
proposed
to
design
I
photosensitizers
(PSs)
photothermal
reagents.
Acceptor
can
not
only
enforce
intramolecular
charge
transfer
redshift
NIR
absorption
but
also
PSs
from
photochemical
pathways.
Donor
optimizes
conversion
efficiency
(PCE).
Accordingly,
three
3,6-divinyl-substituted
diketopyrrolopyrrole
(DPP)
derivatives,
2TPAVDPP,
TPATPEVDPP,
2TPEVDPP,
with
different
number
rotors
were
prepared.
Experimental
results
showed
that
compounds
excellent
PSs,
corresponding
2TPEVDPP
nanoparticles
(NPs)
most
possessed
highest
PCE.
The
photophysical
properties
NPs
are
particularly
suitable
for
in
vivo
fluorescence
imaging-guided
synergistic
PDT/PTT
therapy.
helpful
exploiting
phototherapeutic
reagents
high
efficacy
PDT
PTT.
Nano Convergence,
Journal Year:
2021,
Volume and Issue:
8(1)
Published: Nov. 2, 2021
Modern
medicine
has
been
waging
a
war
on
cancer
for
nearly
century
with
no
tangible
end
in
sight.
Cancer
treatments
have
significantly
progressed,
but
the
need
to
increase
specificity
and
decrease
systemic
toxicities
remains.
Early
diagnosis
holds
key
improving
prognostic
outlook
patient
quality
of
life,
diagnostic
tools
are
cusp
technological
revolution.
Nanotechnology
steadily
expanded
into
reaches
chemotherapy,
radiotherapy,
diagnostics,
imaging,
demonstrating
capacity
augment
each
advance
care.
Nanomaterials
provide
an
abundance
versatility,
functionality,
applications
engineer
specifically
targeted
medicine,
accurate
early-detection
devices,
robust
imaging
modalities,
enhanced
radiotherapy
adjuvants.
This
review
provides
insights
current
clinical
pre-clinical
nanotechnological
drug
therapy,
radiation
therapy.
Small,
Journal Year:
2022,
Volume and Issue:
18(16)
Published: Jan. 27, 2022
Abstract
Ultrasmall
nanoparticles
are
often
grouped
under
the
broad
umbrella
term
of
“nanoparticles”
when
reported
in
literature.
However,
for
biomedical
applications,
their
small
sizes
give
them
intimate
interactions
with
biological
species
and
endow
unique
functional
physiochemical
properties.
Carbon
quantum
dots
(CQDs)
an
emerging
class
ultrasmall
which
have
demonstrated
considerable
biocompatibility
been
employed
as
potent
theragnostic
platforms.
These
particles
find
application
increasing
drug
solubility
targeting,
along
facilitating
passage
drugs
across
impermeable
membranes
(i.e.,
blood
brain
barrier).
Further
functionality
can
be
triggered
by
various
environmental
conditions
or
external
stimuli
pH,
temperature,
near
Infrared
(NIR)
light,
ultrasound),
intrinsic
fluorescence
is
valuable
diagnostic
applications.
The
focus
this
review
to
shed
light
on
therapeutic
potential
CQDs
identify
how
they
travel
through
body,
reach
site
action,
administer
effect,
excreted.
Investigation
into
toxicity
compatibility
larger
nanoparticle
carriers
also
examined.
future
applications
promising
due
multifunctional
attributes
documented
biocompatibility.
As
nanomaterial
platforms
become
more
commonplace
clinical
treatments,
commercialization
CQD
therapeutics
anticipated.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(11), P. 4799 - 4809
Published: Feb. 22, 2022
Chemodrug
resistance
is
a
major
reason
accounting
for
tumor
recurrence.
Given
the
mechanistic
complexity
of
chemodrug
resistance,
molecular
inhibitors
and
targeting
drugs
often
fail
to
eliminate
drug-resistant
cancer
cells,
sometimes
even
promote
chemoresistance
by
activating
alternative
pathways.
Here,
exploiting
biochemical
fragility
high-level
but
dynamically
balanced
cellular
redox
homeostasis
in
we
design
nanosized
copper/catechol-based
metal-organic
framework
(CuHPT)
that
effectively
disturbs
this
tilting
balance
toward
oxidative
stress.
Within
CuHPT
starts
disassembly
triggered
persistent
consumption
glutathione
(GSH).
simultaneously
releases
two
structural
elements:
catechol
ligands
reductive
copper
ions
(Cu+).
Both
them
cooperatively
function
amplify
production
intracellular
radical
species
(ROS)
via
auto-oxidation
Fenton-like
reactions
through
exhausting
GSH.
By
drastically
heightening
stress,
exhibits
selective
potent
cytotoxicity
multiple
cells.
Importantly,
inhibits
vivo
growth
doubles
survival
time
tumor-bearing
mice.
Thus,
along
with
CuHPT's
good
biocompatibility,
our
biochemical,
cell
biological,
preclinical
animal
model
data
provide
compelling
evidence
supporting
notion
copper-based
MOF
predesigned
smart
therapeutic
against
cancers
precisely
deconstructing
their
homeostasis.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(6), P. 2031 - 2081
Published: Jan. 1, 2023
Bioactive
materials
are
a
special
class
of
biomaterials
that
can
react
in
vivo
to
induce
biological
response
or
regulate
functions,
thus
achieving
better
curative
effect
than
traditional
inert
biomaterials.
For
cancer
theranostics,
compared
with
organic
polymer
nanomaterials,
inorganic
nanomaterials
possess
unique
physical
and
chemical
properties,
have
stronger
mechanical
stability
on
the
basis
maintaining
certain
bioactivity,
easy
be
compounded
various
carriers
(polymer
carriers,
etc.),
so
as
achieve
specific
antitumor
efficacy.
After
entering
nanoscale,
due
nano-size
effect,
high
surface
area
nanostructures,
exhibit
effects,
which
significantly
influence
interaction
organisms.
Therefore,
research
applications
bioactive
theranostics
attracted
wide
attention.
In
this
review,
we
mainly
summarize
recent
progress
also
introduce
definition,
synthesis
modification
strategies
nanomaterials.
Thereafter,
tumor
imaging
therapy,
including
microenvironment
(TME)
regulation,
catalytic
gas
regulatory
cell
death
immunotherapy,
discussed.
Finally,
biosafety
challenges
mentioned,
their
future
development
opportunities
prospected.
This
review
highlights
bioapplication
