Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 48(7), P. 2053 - 2108

Published: Sept. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Language: Английский

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Nanotechnology for Multimodal Synergistic Cancer Therapy

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(22), P. 13566 - 13638

Published: Oct. 19, 2017

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential treatment. Therefore, current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, cooperative enhancement interactions between several types contribute naissance multimodal synergistic therapy, which results remarkable superadditive (namely "1 + 1 > 2") effects, stronger than any single or their theoretical combination. In this review, state-of-the-art studies concerning recent advances nanotechnology-mediated will be systematically discussed, with an emphasis construction multifunctional nanomaterials realizing bimodal trimodal as well intensive exploration underlying mechanisms explaining significant improvements outcome. Furthermore, featured applications overcoming tumor multidrug resistance, hypoxia, metastasis also discussed detail, may provide new ways efficient regression even elimination drug resistant, hypoxic solid, distant metastatic tumors. Finally, some design tips outlook future development provided, highlighting key scientific issues technical challenges requiring remediation accelerate translation.

Language: Английский

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Electrochemical sensor and biosensor platforms based on advanced nanomaterials for biological and biomedical applications

Biosensors and Bioelectronics, Journal Year: 2017, Volume and Issue: 103, P. 113 - 129

Published: Dec. 22, 2017

Language: Английский

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Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Chemical Society Reviews, Journal Year: 2018, Volume and Issue: 47(8), P. 2873 - 2920

Published: Jan. 1, 2018

Exploring and understanding biological pathological changes are of great significance for early diagnosis therapy diseases. Optical sensing imaging approaches have experienced major progress in this field. Particularly, an emergence various functional optical nanoprobes has provided enhanced sensitivity, specificity, targeting ability, as well multiplexing multimodal capabilities due to improvements their intrinsic physicochemical properties. However, one the biggest challenges conventional is absolute intensity-dependent signal readout, which causes inaccurate results presence analyte-independent factors that can cause fluctuations intensity. Ratiometric measurements provide built-in self-calibration correction, enabling more sensitive reliable detection. Optimizing nanoprobe designs with ratiometric strategies surmount many limitations encountered by traditional nanoprobes. This review first elaborates upon existing exploit improved imaging, including fluorescence, surface Raman scattering (SERS), photoacoustic Next, a thorough discussion on design these nanoprobes, potential biomedical applications specific biomolecule populations (e.g. cancer biomarkers small molecules physiological relevance), tumor microenvironment pH, reactive oxygen species, hypoxia, enzyme metal ions), intraoperative image guidance tumor-resection procedures.

Language: Английский

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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment

Chemical Reviews, Journal Year: 2017, Volume and Issue: 117(20), P. 12764 - 12850

Published: Oct. 9, 2017

The cell microenvironment has emerged as a key determinant of behavior and function in development, physiology, pathophysiology. extracellular matrix (ECM) within the serves not only structural foundation for cells but also source three-dimensional (3D) biochemical biophysical cues that trigger regulate behaviors. Increasing evidence suggests 3D character is required development many critical responses observed vivo, fueling surge functional biomimetic materials engineering microenvironment. Progress design such improved control behaviors advanced fields tissue regeneration, vitro models, large-scale differentiation, immunotherapy, gene therapy. However, field still its infancy, discoveries about nature cell–microenvironment interactions continue to overturn much early progress field. Key challenges be dissecting roles chemistry, structure, mechanics, electrophysiology microenvironment, understanding harnessing periodicity drift these factors. This review encapsulates where recent advances appear leave ever-shifting state art, it highlights areas which substantial potential uncertainty remain.

Language: Английский

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Persistent luminescence instead of phosphorescence: History, mechanism, and perspective

Journal of Luminescence, Journal Year: 2018, Volume and Issue: 205, P. 581 - 620

Published: Sept. 28, 2018

Language: Английский

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Recent progress of nanomaterials for microwave absorption

Journal of Materiomics, Journal Year: 2019, Volume and Issue: 5(4), P. 503 - 541

Published: July 15, 2019

Microwave absorbing materials have received considerable interest over the years for their applications in stealth, communications, and information processing technologies. These often require functionalization at nanoscale so to achieve desirable dielectric magnetic properties which induce interaction with incident electromagnetic radiation. This article presents a comprehensive review on recent research progress of nanomaterials microwave absorption, including basic mechanism absorption (e.g., loss, dielectric/magnetic loss coupling), measurement principle fundamentals analysis, performance evaluation, common pathways: Debye relaxation, Eddy current natural resonance, size shape factors), advances bandwidth, reflection values, peak position) using various nanomaterials, such as carbon nanotubes, fibers, graphenes, oxides, sulfides, phosphides, carbides, polymers metal organic frameworks. Overall, this not only provides an introduction research, but also timely update nanomaterials.

Language: Английский

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Nanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery

Chemical Reviews, Journal Year: 2019, Volume and Issue: 119(16), P. 9559 - 9656

Published: July 9, 2019

Nanocarbons with different dimensions (e.g., 0D fullerenes and carbon nanodots, 1D nanotubes graphene nanoribbons, 2D oxides, 3D nanodiamonds) have attracted enormous interest for applications ranging from electronics, optoelectronics, photovoltaics to sensing, bioimaging, therapeutics due their unique physical chemical properties. Among them, nanocarbon-based theranostics (i.e., diagnostics) is one of the most intensively studied applications, as these nanocarbon materials serve excellent biosensors, versatile drug/gene carriers specific targeting in vivo, effective photothermal nanoagents cancer therapy, promising fluorescent nanolabels cell tissue imaging. This review provides a systematic overview latest theranostic comprehensive comparison characteristics influences on applications. We first introduce allotropes that can be used respective preparation surface functionalization approaches well Theranostic are described separately both vitro vivo systems by highlighting protocols biosystems, followed toxicity biodegradability implications. Finally, this outlines design considerations key unifying themes will foundational principle researchers study, investigate, generate effective, biocompatible, nontoxic materials-based models we summarize an outlook challenges novel using hard-to-treat cancers other diseases. intends present guideline nanotechnology biomedicine selection strategy according requirements.

Language: Английский

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Multimodal Biophotonics of Semiconducting Polymer Nanoparticles

Accounts of Chemical Research, Journal Year: 2018, Volume and Issue: 51(8), P. 1840 - 1849

Published: Aug. 3, 2018

ConspectusBiophotonics as an interdisciplinary frontier plays increasingly important role in modern biomedical science. Optical agents are generally involved biophotonics to interpret biomolecular events into readable optical signals for imaging and diagnosis or convert photons other forms of energy (such heat, mechanical force, chemical radicals) therapeutic intervention biological stimulation. Development new including metallic nanoparticles, quantum dots, up-conversion carbon silica nanoparticles has contributed the advancement this field. However, most these have their own merits demerits, making them less effective multimodal biophotonic platforms.In Account, we summarize our recent work on development near-infrared (NIR) semiconducting polymer (SPNs) light converters advanced biophotonics. SPNs composed π-electron delocalized polymers (SPs) often possess advantages good biocompatibility, high photostability, large absorption coefficients. Because photophysical properties mainly determined by molecular structures precursor polymers, engineering allows us fine tune processes obtain different responses, even second NIR window (1000–1700 nm). Meanwhile, facile nanoformulation methods enable alteration outer inner diverse interactions.The unique brought about ultrasensitive deep-tissue imaging. NIR-absorbing with strong charge-transfer backbones can photoenergy acoustic waves, permitting photoacoustic that bypasses issue scattering reaches centimeter tissue penetration depth. Differently, phenylenevinylene-containing store photon via defects emit long-NIR afterglow luminescence a half-life ∼6 min after cessation excitation. Such process avoids autofluorescence, giving rise ultrahigh signal-to-background ratios. So far, SPN-based probes been developed image disease tissues (tumors), biomarkers (biothiols reactive oxygen species), physiological indexes (pH temperature) preclinical animal models.The synthetic flexibility further permits light-modulated interventions. Till now, photothermal conversion efficiencies shaped transducers remotely regulate protein ion channels, enzymatic activity, gene expression. In conjunction desired biodistribution tumor-homing ability, doped coated inorganic amplified self-regulated photodynamic cancer therapy.This Account thus demonstrates serve nanoplatform provide unprecedented opportunities imaging, noninvasive bioactivation, therapy.

Language: Английский

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Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(23), P. 7438 - 7468

Published: Jan. 1, 2017

This review focuses on the design principles of inorganic nanoparticles to engineer high-performance contrast agents for magnetic resonance imaging.

Language: Английский

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