Analysis, environmental occurrence, fate and potential toxicity of tire wear compounds 6PPD and 6PPD-quinone

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131245 - 131245

Published: March 21, 2023

Language: Английский

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Widespread Occurrence and Transport of p-Phenylenediamines and Their Quinones in Sediments across Urban Rivers, Estuaries, Coasts, and Deep-Sea Regions

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(6), P. 2393 - 2403

Published: Jan. 31, 2023

p-Phenylenediamines (PPDs) are widely used as antioxidants in tire rubber, and their derived quinone transformation products (PPD-Qs) may pose a threat to marine ecosystems. A compelling example is N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD)-derived quinone, called 6PPD-Q, the causal toxicant for stormwater-linked acute mortality toward coho salmon. However, knowledge of co-occurrences PPDs PPD-Qs transport from freshwater oceanic waterbodies on large geographical scale remains unknown. Herein, we performed first large-scale survey these chemicals sediments across urban rivers, estuaries, coasts, deep-sea regions. Our results demonstrated that seven four ubiquitously present riverine, estuarine, coastal sediments, most them also occur sediments. The dominant concern were identified 6PPD 6PPD-Q. Total sedimentary concentrations presented clear spatial trend with decreasing levels rivers (medians: 39.7 15.2 ng/g) estuaries (14.0 5.85 then coasts (9.47 2.97 regions (5.24 3.96 ng/g). Interestingly, variation ratios 6PPD-Q (R6PPD/6PPD-Q) trend. field measurements implied riverine outflows be an important route rubber-derived open oceans.

Language: Английский

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Screening p-Phenylenediamine Antioxidants, Their Transformation Products, and Industrial Chemical Additives in Crumb Rubber and Elastomeric Consumer Products

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(7), P. 2779 - 2791

Published: Feb. 9, 2023

Recently, roadway releases of

Language: Английский

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Environmental Occurrence and Toxicity of 6PPD Quinone, an Emerging Tire Rubber-Derived Chemical: A Review

Environmental Science & Technology Letters, Journal Year: 2023, Volume and Issue: 10(10), P. 815 - 823

Published: Sept. 1, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a chemical added to tires prevent their oxidative degradation. 6PPD highly reactive with ozone and oxygen, leading the formation of transformation products such as quinone (6PPDQ) on tire surfaces and, subsequently, in road wear particles. 6PPDQ toxicant that has been found roadway runoff receiving water systems. Its presence municipal stormwater led acute mortality coho salmon during migration urban creeks reproduce, generating global interest studying its occurrence toxicity environment. This review aims provide critical overview current state knowledge 6PPDQ, assisting researchers policymakers understanding potential impacts this emerging environment human health. As there are many unanswered questions surrounding further research needed. highlights importance including regulations for 6PPD, well all synthetic chemicals concern.

Language: Английский

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Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 894, P. 164842 - 164842

Published: June 17, 2023

Language: Английский

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Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(36), P. 13429 - 13438

Published: Aug. 29, 2023

The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity 6PPDQ are unknown. Here, we treated C57Bl/6 mice with 4 mg/kg or investigate urine excretion transfer. Female male exhibited sex difference profiles 6PPDQ. Urine concentrations were one order magnitude lower than those 6PPD, suggesting higher bioaccumulation In from embryonic day 11.5 15.5, showed ∼1.5–8 times placenta, embryo body, brain, Using vitro dual-luciferase reporter assays, revealed that activated human retinoic acid receptor α (RARα) retinoid X (RXRα) at as low 0.3 μM, which was ∼10-fold detected urines. RXRα 1.2 μM. These results demonstrate exposure risks during pregnancy emphasize need for further toxicological epidemiological investigations.

Language: Английский

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Where the rubber meets the road: Emerging environmental impacts of tire wear particles and their chemical cocktails

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 171153 - 171153

Published: March 7, 2024

About 3 billion new tires are produced each year and about 800 million become waste annually. Global dependence upon from natural rubber petroleum-based compounds represents a persistent complex environmental problem with only partial often-times, ineffective solutions. Tire emissions may be in the form of whole tires, tire particles, chemical compounds, which is transported through various atmospheric, terrestrial, aquatic routes built environments. Production use generates multiple heavy metals, plastics, PAH's, other that can toxic alone or as cocktails. Used require storage space, energy intensive to recycle, generally have few post-wear uses not also potential sources pollutants (e.g., crumb rubber, pavements, burning). particles emitted during major component microplastics urban runoff source unique highly potent substances. Thus, represent ubiquitous pollutant requires comprehensive examination develop effective management remediation. We approach issue pollution holistically by examining life cycle across production, emissions, recycling, disposal. In this paper, we synthesize recent research data human health risks associated use, disposal discuss gaps our knowledge fate transport, well toxicology leachates. examine remediation approaches for addressing exposure tires. consider three levels: their state, particulates, mixture Finally, information understanding outline key questions improve ability manage remediate pollution.

Language: Английский

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Amino antioxidants: A review of their environmental behavior, human exposure, and aquatic toxicity

Chemosphere, Journal Year: 2023, Volume and Issue: 317, P. 137913 - 137913

Published: Jan. 20, 2023

Language: Английский

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Synthetic Antioxidants as Contaminants of Emerging Concern in Indoor Environments: Knowns and Unknowns

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(51), P. 21550 - 21557

Published: Dec. 12, 2023

Synthetic antioxidants, including synthetic phenolic antioxidants (SPAs), amine (AAs), and organophosphite (OPAs), are essential additives for preventing oxidative aging in various industrial consumer products. Increasing attention has been paid to the environmental contamination caused by these chemicals, but our understanding of is generally limited compared other emerging contaminants such as plasticizers flame retardants. Many people spend a significant portion (normally greater than 80%) their time indoors, meaning that they experience widespread persistent exposure indoor contaminants. Thus, this Perspective focuses on problem The wide application commercial products demonstrated toxicity make them an important family concern. However, knowledge gaps still need be bridged: novel related transformation identified environments, different dust sampling strategies should employed evaluate human contaminants, geographic scope research broadened, partition coefficients among media investigated.

Language: Английский

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Chemical characteristics, leaching, and stability of the ubiquitous tire rubber-derived toxicant 6PPD-quinone

Environmental Science Processes & Impacts, Journal Year: 2023, Volume and Issue: 25(5), P. 901 - 911

Published: Jan. 1, 2023

We here report chemical characteristics relevant to the fate and transport of recently discovered environmental toxicant 6PPD-quinone (2-((4-methylpentan-2-yl)amino)-5-(phenylamino)cyclohexa-2,5-diene-1,4-dione or “6PPDQ”).

Language: Английский

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