Genome mining of nonenzymatic ortho-quinone methide-based pseudonatural products from ascidian-derived fungus Diaporthe sp.SYSU-MS4722 DOI

Shuya Ren,

Yan Yan, Yongli Zhou

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108081 - 108081

Published: Dec. 23, 2024

Language: Английский

Phytochemicals in Drug Discovery—A Confluence of Tradition and Innovation DOI Open Access

Patience Chihomvu,

A. Ganesan, Simon Gibbons

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8792 - 8792

Published: Aug. 13, 2024

Phytochemicals have a long and successful history in drug discovery. With recent advancements analytical techniques methodologies, discovering bioactive leads from natural compounds has become easier. Computational like molecular docking, QSAR modelling machine learning, network pharmacology are among the most promising new tools that allow researchers to make predictions concerning products’ potential targets, thereby guiding experimental validation efforts. Additionally, approaches LC-MS or LC-NMR speed up compound identification by streamlining processes. Integrating structural computational biology aids lead identification, thus providing invaluable information understand how phytochemicals interact with targets body. An emerging approach is learning involving deep neural networks interrelate phytochemical properties diverse physiological activities such as antimicrobial anticancer effects.

Language: Английский

Citations

13

Sterpiperazines A and B, steroid-indole alkaloids with Tdp1 inhibitory and chemotherapy sensitizing activities from marine fungus Aspergillus sp. EGF 15-0-3 DOI
Wei Xia,

Zheng-Wu Luo,

Guoqiang Zhang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111048 - 111048

Published: March 1, 2025

Language: Английский

Citations

1

Advances in triterpene drug discovery DOI Creative Commons
Zoë Goddard, Mark Searcey, Anne Osbourn

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(11), P. 964 - 968

Published: Oct. 31, 2024

Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery optimisation of a new generation leads.

Language: Английский

Citations

6

In vivo wound healing activity of electrospun nanofibers embedding natural products DOI Creative Commons

Breno de Almeida Bertassoni,

Denise de Abreu Garófalo, Mariana Sato de Souza de Bustamante Monteiro

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106019 - 106019

Published: Oct. 15, 2024

Language: Английский

Citations

3

Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin DOI Creative Commons

Liliane Patrícia Gonçalves Tenório,

Felipe Henrique da Cunha Xavier,

Mônica Silveira Wagner

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells change into mesenchymal with fibroblast-like characteristics. EMT plays crucial role the progression of fibrosis. Classical inducers associated maintenance EMT, such as TGF-β1, have become targets several anti-EMT therapeutic strategies. Natural products from pentacyclic triterpene class emerged promising elements inhibiting EMT. Uvaol found olive trees (Olea europaea L.) known for its anti-inflammatory, antioxidant, and antiproliferative properties. Yet, effect on TGF-β1-induced alveolar unknown. present study aimed to investigate impact uvaol upon cultured A549 human cell line, classic vitro model studies Changes shape were measured using phase-contrast confocal microscopy, whereas protein expression levels immunofluorescence, flow cytometry, Western blotting. We also performed wound scratch experiments explore effects migration. had no significant cytotoxic cells. By contrast, changes morphology consistent largely suppressed by treatment uvaol. In addition, increased contents markers, namely, vimentin, N-cadherin, fibronectin cells, downregulated treatment. Furthermore, migration was significantly Mechanistically, prevented nuclear translocation β-catenin reduced ZEB1 These results provide compelling evidence that inhibits regulating proteins related profile likely modulating levels.

Language: Английский

Citations

0

Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist DOI
Lu Wang, Yan Geng, Lifang Liu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117461 - 117461

Published: Feb. 28, 2025

Language: Английский

Citations

0

Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells DOI

Ting-Lei Gu,

Raju R. Raval, Zachary Bashkin

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 121, P. 130163 - 130163

Published: March 3, 2025

Language: Английский

Citations

0

Identification of SRC, AKT1 and MAPK3 as Therapeutic Targets of Apigenin and Luteolin in Colorectal and Colon Carcinoma through Network Pharmacology DOI Creative Commons
Kha Wai Hon, Sagnik Nag,

B. Stany

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106313 - 106313

Published: March 1, 2025

Language: Английский

Citations

0

Structurally diverse sesquiterpenes with anti-leukemia activity from the rare medicinal plant Liriodendron chinense DOI

Yu‐Hang He,

Hong Xiang,

Zi‐Jie Long

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 158, P. 108341 - 108341

Published: March 8, 2025

Language: Английский

Citations

0

Privileged natural product compound classes for anti-inflammatory drug development DOI Creative Commons
Malcolm Z. Y. Choo, J. Chua, S. Lee

et al.

Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights six privileged classes of natural products – coumarins, polyphenols, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids—for potential anti-inflammatory drug development.

Language: Английский

Citations

0