Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108081 - 108081
Published: Dec. 23, 2024
Language: Английский
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108081 - 108081
Published: Dec. 23, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8792 - 8792
Published: Aug. 13, 2024
Phytochemicals have a long and successful history in drug discovery. With recent advancements analytical techniques methodologies, discovering bioactive leads from natural compounds has become easier. Computational like molecular docking, QSAR modelling machine learning, network pharmacology are among the most promising new tools that allow researchers to make predictions concerning products’ potential targets, thereby guiding experimental validation efforts. Additionally, approaches LC-MS or LC-NMR speed up compound identification by streamlining processes. Integrating structural computational biology aids lead identification, thus providing invaluable information understand how phytochemicals interact with targets body. An emerging approach is learning involving deep neural networks interrelate phytochemical properties diverse physiological activities such as antimicrobial anticancer effects.
Language: Английский
Citations
13Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111048 - 111048
Published: March 1, 2025
Language: Английский
Citations
1Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(11), P. 964 - 968
Published: Oct. 31, 2024
Triterpenes are structurally complex natural products with promising therapeutic properties. Recalcitrance to chemical synthesis has hindered their use in drug development. Recent advances now make it possible access and harness triterpene structural diversity using engineering biology approaches, enabling the discovery optimisation of a new generation leads.
Language: Английский
Citations
6Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(12), P. 106019 - 106019
Published: Oct. 15, 2024
Language: Английский
Citations
3Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
The epithelial-mesenchymal transition (EMT) is a biological process in which epithelial cells change into mesenchymal with fibroblast-like characteristics. EMT plays crucial role the progression of fibrosis. Classical inducers associated maintenance EMT, such as TGF-β1, have become targets several anti-EMT therapeutic strategies. Natural products from pentacyclic triterpene class emerged promising elements inhibiting EMT. Uvaol found olive trees (Olea europaea L.) known for its anti-inflammatory, antioxidant, and antiproliferative properties. Yet, effect on TGF-β1-induced alveolar unknown. present study aimed to investigate impact uvaol upon cultured A549 human cell line, classic vitro model studies Changes shape were measured using phase-contrast confocal microscopy, whereas protein expression levels immunofluorescence, flow cytometry, Western blotting. We also performed wound scratch experiments explore effects migration. had no significant cytotoxic cells. By contrast, changes morphology consistent largely suppressed by treatment uvaol. In addition, increased contents markers, namely, vimentin, N-cadherin, fibronectin cells, downregulated treatment. Furthermore, migration was significantly Mechanistically, prevented nuclear translocation β-catenin reduced ZEB1 These results provide compelling evidence that inhibits regulating proteins related profile likely modulating levels.
Language: Английский
Citations
0European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117461 - 117461
Published: Feb. 28, 2025
Language: Английский
Citations
0Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: 121, P. 130163 - 130163
Published: March 3, 2025
Language: Английский
Citations
0Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106313 - 106313
Published: March 1, 2025
Language: Английский
Citations
0Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 158, P. 108341 - 108341
Published: March 8, 2025
Language: Английский
Citations
0Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review highlights six privileged classes of natural products – coumarins, polyphenols, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids—for potential anti-inflammatory drug development.
Language: Английский
Citations
0