Smart stimuli-responsive injectable gels and hydrogels for drug delivery and tissue engineering applications: A review DOI Creative Commons

Saba Salehi,

Seyed Morteza Naghib, Hamid Reza Garshasbi

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 22, 2023

Hydrogels are widely used biomaterials in the delivery of therapeutic agents, including drugs, genes, proteins, etc., as well tissue engineering, due to obvious properties such biocompatibility and their similarity natural body tissues. Some these substances have feature injectability, which means that substance is injected into desired place solution state then turns gel, makes it possible administer them from a way with minimal amount invasion eliminate need for surgery implant pre-formed materials. Gelation can be caused by stimulus and/or spontaneously. Suppose this induces effect one or many stimuli. In case, material question called stimuli-responsive because responds surrounding conditions. context, we introduce different stimuli cause gelation investigate mechanisms transformation gel them. Also, study special structures, nano gels nanocomposite gels.

Language: Английский

Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering DOI Creative Commons
Xue Xu, Yan Hu, Sicheng Wang

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 12, P. 327 - 339

Published: Oct. 26, 2021

Bone tissue engineering has emerged as a significant research area that provides promising novel tools for the preparation of biomimetic hydrogels applied in bone-related diseases (e.g., bone defects, cartilage damage, osteoarthritis, etc.). Herein, thermal sensitive polymers PNIPAAm, Soluplus, etc.) were introduced into main chains to fabricate with injectability and compatibility those defect need minimally invasive surgery. Mineral ions calcium, copper, zinc, magnesium), an indispensable role maintaining balance organism, linked polymer form functional accelerating regeneration. In chemically triggered hydrogel section, advanced crosslinked by different molecular agents genipin, dopamine, caffeic acid, tannic acid) possess many advantages, including extensive selectivity, rapid gel-forming capacity tunable mechanical property. Additionally, photo crosslinking response mild condition can be photoinitiators I2959, LAP, eosin Y, riboflavin, under specific wavelength light. Moreover, enzyme also utilized regeneration due its excellent biocompatibility. Particularly, some key factors determine therapy effect mentioned. Finally, brief summaries remaining issues on how properly design clinical-oriented provided this review.

Language: Английский

Citations

340
Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications DOI Creative Commons

Hussein M. El‐Husseiny,

Eman A. Mady, Lina Hamabe

et al.

Materials Today Bio, Journal Year: 2021, Volume and Issue: 13, P. 100186 - 100186

Published: Dec. 9, 2021

Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left door open for further improvement their applications to revitalize impaired tissues. Hence, restoring functions. The implementation therapeutic protocols merge biomimetic scaffolds, bioactive molecules, cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended engineering other biomedical purposes. They can simulate physicochemical, mechanical, biological characters innate Also, they provide aqueous conditions cell growth, support 3D conformation, mechanical stability cells, serve potent delivery matrices molecules. Many natural artificial polymers were broadly utilized design these intelligent platforms with novel advanced characteristics tailored functionalities fit such applications. In present review, we highlighted different types smart/stimuli-responsive emphasis on synthesis scheme. Besides, mechanisms responsiveness stimuli elaborated. Their potential was discussed. Furthermore, exploitation targeted drug delivery, smart biosensors, actuators, 4D printing, culture outlined. addition, threw light self-healing biomedicine. Eventually, presented future perceptions Conclusively, current progress enhances prospective function intelligent, sophisticated systems

Language: Английский

Citations

331
Recent advances in polysaccharide-based self-healing hydrogels for biomedical applications DOI

Yongyan Yang,

Lifeng Xu,

Jingfei Wang

et al.

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 283, P. 119161 - 119161

Published: Jan. 25, 2022

Language: Английский

Citations

210
Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment DOI Creative Commons
Xiaoyu Xu, Chang Liu, Yonghui Wang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 176, P. 113891 - 113891

Published: July 26, 2021

CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-associated protein 9) is a potent technology for gene-editing. Owing to its high specificity and efficiency, extensity used human diseases treatment, especially cancer, which involves multiple genetic alterations. Different concepts of cancer treatment by are established. However, significant challenges remain clinical applications. The greatest challenge therapy how safely efficiently deliver it target sites in vivo. Nanotechnology has greatly contributed drug delivery. Here, we present the action mechanisms CRISPR/Cas9, application focus on nanotechnology-based delivery gene editing immunotherapy pave way translation. We detail difficult barriers CRISIR/Cas9 vivo discuss relative solutions encapsulation, delivery, controlled release, cellular internalization, endosomal escape.

Language: Английский

Citations

181
Recent advances in the synthesis of smart hydrogels DOI Creative Commons
Partha Sikdar, Md Mazbah Uddin, Tanvir Mahady Dip

et al.

Materials Advances, Journal Year: 2021, Volume and Issue: 2(14), P. 4532 - 4573

Published: Jan. 1, 2021

Understanding the surrounding atmosphere and reacting accordingly with a precise action are always fascinating features of material.

Language: Английский

Citations

160
Wood-Derived Hydrogels as a Platform for Drug-Release Systems DOI Creative Commons
Mario Culebras,

Anthony P. Barrett,

Mahboubeh Pishnamazi

et al.

ACS Sustainable Chemistry & Engineering, Journal Year: 2021, Volume and Issue: 9(6), P. 2515 - 2522

Published: Jan. 22, 2021

Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic cross-linking behaviors of precursor solutions tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range 100–160 μm obtained. Varying lignin molecular structure played a key role tailoring swelling mechanical performance these gels with organosolv-type showing optimum properties due its propensity intermolecular cross-linking, achieving compressive modulus around 11 kPa. Paracetamol was selected standard drug release tests rate improved presence (50% more compared pure cellulose hydrogels). This attributed reduction interactions between paracetamol cellulose. These results highlight potential valorization platform

Language: Английский

Citations

151
Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering DOI
Yidong Zou, Biaotong Huang, Liehu Cao

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(2)

Published: Nov. 30, 2020

Abstract Infectious or immune diseases have caused serious threat to human health due their complexity and specificity, emerging drug delivery systems (DDSs) evolved into the most promising therapeutic strategy for drug‐targeted therapy. Various mesoporous biomaterials are exploited applied as efficient nanocarriers loading drugs by virtue of large surface area, high porosity, prominent biocompatibility. Nanosized show great potential in biomedical research, it has become research hotspot interdisciplinary field. Herein, recent progress assembly mechanisms on inorganic (e.g., silica, carbon, metal oxide) summarized systematically, typical functionalization methods (i.e., hybridization, polymerization, doping) also discussed depth. Particularly, structure–activity relationship effect physicochemical parameters biomaterials, including morphologies hollow, core–shell), pore textures size, volume), features roughness hydrophilic/hydrophobic) DDS application overviewed elucidated detail. As one important development directions, advanced stimuli‐responsive DDSs pH, temperature, redox, ultrasound, light, magnetic field) highlighted. Finally, prospect disease therapeutics is stated, will open a new spring nanocarriers.

Language: Английский

Citations

146
Recent developments in chitosan hydrogels carrying natural bioactive compounds DOI
Nga H. N.,

Quyen T. Truong,

Phung K. Le

et al.

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 294, P. 119726 - 119726

Published: June 14, 2022

Language: Английский

Citations

138
Poly(vinyl alcohol) Hydrogels: The Old and New Functional Materials DOI Creative Commons
Menghan Wang,

Jianzhong Bai,

Kan Shao

et al.

International Journal of Polymer Science, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 16

Published: Nov. 30, 2021

Hydrogels have three-dimensional network structures, high water content, good flexibility, biocompatibility, and stimulation response, which provided a unique role in many fields such as industry, agriculture, medical treatment. Poly(vinyl alcohol) PVA hydrogel is one of the oldest composite hydrogels. It has been extensively explored due to its chemical stability, nontoxic, biological aging resistance, water-absorbing capacity, easy processing. PVA-based hydrogels widely investigated drug carriers, articular cartilage, wound dressings, tissue engineering, other intelligent materials, self-healing shape-memory supercapacitors, sensors, fields. In this paper, discovery, development, preparation, modification methods, applications functionalized are reviewed, their potential future research trends also prospected.

Language: Английский

Citations

128
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches DOI Creative Commons
Milad Ashrafizadeh, Masoud Delfi, Ali Zarrabi

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 50 - 80

Published: Sept. 20, 2022

The site-specific delivery of antitumor agents is importance for providing effective cancer suppression. Poor bioavailability anticancer compounds and the presence biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. challenges chemotherapy stimuli-responsive nanocarriers are first described current review. Then, liposomes including pH-, redox-, enzyme-, light-, thermo- magneto-sensitive nanoparticles discussed potential drugs emphasized. pH- or redox-sensitive based on internal stimulus release drug response to a mildly acidic pH GSH, respectively. pH-sensitive mediate endosomal escape via proton sponge. multifunctional responsive both redox have more capacity at site compared alone. magnetic field NIR irradiation exploited external stimulation liposomes. light-responsive when they exposed irradiation; thermosensitive-liposomes temperature >40 °C there hyperthermia; magneto-responsive field. smart nanoliposomes also co-delivery genes synergistic therapy. Due lack long-term toxicity liposomes, utilized near future treatment patients.

Language: Английский

Citations

124