Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 7, 2024
Nanozymes
with
peroxidase
(POD)-like
activity
have
garnered
significant
attention
due
to
their
exceptional
performance
in
colorimetric
assays.
However,
nanozymes
often
possess
oxidase
(OD)
and
POD-like
simultaneously,
which
affects
the
accuracy
sensitivity
of
detection
results.
To
address
this
issue,
inspired
by
catalytic
pocket
natural
POD,
a
single-atom
nanozyme
FeN5
configuration
is
designed,
exhibiting
enhanced
comparison
FeN4
configuration.
The
axial
N
atom
highly
mimics
amino
acid
residues
POD
optimize
electronic
structure
metal
active
center
Fe,
realizing
efficient
activation
H2O2.
In
addition,
presence
both
H2O2
O2,
enhances
H2O2,
effectively
avoiding
interference
dissolved
oxygen
sensing.
As
proof-of-concept
application,
platform
for
uranyl
ions
(UO22+)
seawater
successfully
constructed,
demonstrating
satisfactory
specificity.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 2533 - 2540
Published: Jan. 12, 2024
Nanozymes,
nanomaterials
exhibiting
enzyme-like
activities,
have
emerged
as
a
prominent
interdisciplinary
field
over
the
past
decade.
To
date,
1200
different
been
identified
nanozymes,
covering
four
catalytic
categories:
oxidoreductases,
hydrolases,
isomerases,
and
lyases.
Catalytic
activity
specificity
are
two
pivotal
benchmarks
for
evaluating
enzymatic
performance.
Despite
substantial
progress
being
made
in
quantifying
optimizing
of
there
is
still
lack
in-depth
research
on
preventing
formation
consensual
knowledge
impeding
more
refined
systematic
classification
nanozymes.
Recently,
debates
regarding
whether
nanozymes
could
possess
similar
to
that
enzymes.
This
Perspective
discusses
by
referring
enzymes,
highlights
gap
between
concludes
offering
our
perspective
future
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
53(1), P. 137 - 162
Published: Nov. 29, 2023
Natural
metalloenzymes
with
astonishing
reaction
activity
and
specificity
underpin
essential
life
transformations.
Nevertheless,
enzymes
only
operate
under
mild
conditions
to
keep
sophisticated
structures
active,
limiting
their
potential
applications.
Artificial
that
recapitulate
the
catalytic
of
can
not
circumvent
enzymatic
fragility
but
also
bring
versatile
functions
into
practice.
Among
them,
metal-organic
frameworks
(MOFs)
featuring
diverse
site-isolated
metal
sites
supramolecular
have
emerged
as
promising
candidates
for
move
toward
unparalleled
properties
behaviour
enzymes.
In
this
review,
we
systematically
summarize
significant
advances
in
MOF-based
metalloenzyme
mimics
a
special
emphasis
on
active
pocket
engineering
at
atomic
level,
including
primary
secondary
coordination
spheres.
Then,
deep
understanding
mechanisms
advanced
applications
are
discussed.
Finally,
perspective
emerging
frontier
research
is
provided
advance
bioinspired
catalysis.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(11), P. 5626 - 5676
Published: Jan. 1, 2024
Metalation
of
metal-organic
frameworks
(MOFs)
has
been
developed
as
a
prominent
strategy
for
materials
functionalization
pore
chemistry
modulation
and
property
optimization.
By
introducing
exotic
metal
ions/complexes/nanoparticles
onto/into
the
parent
framework,
many
metallized
MOFs
have
exhibited
significantly
improved
performance
in
wide
range
applications.
In
this
review,
we
focus
on
research
progress
metalation
during
last
five
years,
spanning
design
principles,
synthetic
strategies,
potential
Based
crystal
engineering
minor
change
MOF
composition
through
would
lead
to
leveraged
variation
properties.
This
review
starts
from
general
strategies
established
incorporation
species
within
MOFs,
followed
by
principles
graft
desired
functionality
while
maintaining
porosity
frameworks.
Facile
contributed
great
number
bespoke
with
excellent
performance,
summarize
their
applications
gas
adsorption
separation,
heterogeneous
catalysis,
detection
sensing,
energy
storage
conversion.
The
underlying
mechanisms
are
also
investigated
state-of-the-art
techniques
analyzed
gaining
insight
into
structure-property
relationships,
which
turn
facilitate
further
development
principles.
Finally,
current
challenges
opportunities
discussed,
promising
future
directions
customizing
next-generation
advanced
outlined
well.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Sept. 24, 2023
Copper
(Cu),
an
indispensable
trace
element
within
the
human
body,
serving
as
intrinsic
constituent
of
numerous
natural
enzymes,
carrying
out
vital
biological
functions.
Furthermore,
nanomaterials
exhibiting
enzyme-mimicking
properties,
commonly
known
nanozymes,
possess
distinct
advantages
over
their
enzyme
counterparts,
including
cost-effectiveness,
enhanced
stability,
and
adjustable
performance.
These
advantageous
attributes
have
captivated
attention
researchers,
inspiring
them
to
devise
various
Cu-based
nanomaterials,
such
copper
oxide,
Cu
metal-organic
framework,
CuS,
explore
potential
in
enzymatic
catalysis.
This
comprehensive
review
encapsulates
most
recent
advancements
illuminating
applications
realm
biochemistry.
Initially,
it
is
delved
into
emulation
typical
types
achieved
by
nanomaterials.
Subsequently,
latest
breakthroughs
concerning
nanozymes
biochemical
sensing,
bacterial
inhibition,
cancer
therapy,
neurodegenerative
diseases
treatment
discussed.
Within
this
segment,
also
explored
modulation
nanozyme
activity.
Finally,
a
visionary
outlook
for
future
development
presented.
iScience,
Journal Year:
2025,
Volume and Issue:
28(2), P. 111763 - 111763
Published: Jan. 7, 2025
Recent
years
have
witnessed
tremendous
advances
in
wearable
sensors,
which
play
an
essential
role
personalized
healthcare
for
their
ability
real-time
sensing
and
detection
of
human
health
information.
Nanozymes,
capable
mimicking
the
functions
natural
enzymes
addressing
limitations,
possess
unique
advantages
such
as
structural
stability,
low
cost,
ease
mass
production,
making
them
particularly
beneficial
constructing
recognition
units
biosensors.
In
this
review,
we
aim
to
delineate
latest
advancements
nanozymes
development
biosensors,
focusing
on
key
developments
nanozyme
immobilization
strategies,
technologies,
biomedical
applications.
The
review
also
highlights
current
challenges
future
perspectives.
Ultimately,
it
aims
provide
insights
research
endeavors
rapidly
evolving
area.
