α-C–H Functionalization of Alcohols Delivers C6-Hydroxyalkylated Purines and Purine Nucleosides DOI
Paul Richardson, T. Patrick Montgomery

Synfacts, Journal Year: 2022, Volume and Issue: 18(10), P. 1072 - 1072

Published: Sept. 20, 2022

Key words hydroxyalkylation - alcohols nucleosides purines

Language: Английский

Synthesis of medium-sized benzo[b]azocines and benzo[b]azonines by photoinduced 8-/9-endo sulfonyl-cyclization DOI
Kai Sun, Dongyang Zhao, Quanxin Li

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(8), P. 2309 - 2316

Published: July 24, 2023

Language: Английский

Citations

40
Trifluoromethoxylation/trifluoromethylthiolation/trifluoro- methylselenolation strategy for the construction of heterocycles DOI
Xin Wang,

Zhichuan Wang,

Zhenjian Li

et al.

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(5), P. 108045 - 108045

Published: Dec. 8, 2022

Language: Английский

Citations

33
Chemoselective electrochemical seleno-cyclization of dienes to medium-sized benzo[b]azocines DOI

Zhichuan Wang,

Xin Wang, Q. Li

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(2), P. 109058 - 109058

Published: Sept. 10, 2023

Language: Английский

Citations

15
Metal-free β,γ-C(sp3)–H difunctionalization of propanols: DMP-initiated asymmetric spirocyclopropanation DOI

zheyao li,

Huiwen Zhang,

Lin Zhao

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(26), P. 3579 - 3582

Published: Jan. 1, 2024

This work reports a one-pot asymmetric synthesis of spirocyclopropyl propionaldehydes/propanols via β,γ-bifunctionalization propanols through the synergistic effect secondary amine catalyst and an oxidant.

Language: Английский

Citations

3
Regioselective Homolytic C2–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction DOI

Yangyan Li,

Yutong Zhou,

Dazhi Zhou

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(31), P. 21428 - 21441

Published: July 25, 2024

A Minisci-type borylation of unprotected adenosine, adenine nucleotide, and adenosine analogues was successfully achieved through photocatalysis or thermal activation. Despite the challenges posed by presence two potential reactive sites (C

Language: Английский

Citations

3
Photo/Electrochemical‐Mediated C(sp3)−H Bond Functionalization of (Thio)Ethers DOI

Lianglong Sun,

Dongyang Zhao, Kai Sun

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(17)

Published: March 11, 2024

Abstract Molecules containing ether skeletons are widely present in drugs, natural products, functional materials, and life science. Direct C(sp 3 )−H bond functionalization is considered a powerful strategy for the construction of novel derivatives. Photo‐/electro‐chemical technology relatively green sustainable synthesis method, which opens up broad application prospect field direct bonds. In recent years, photo‐/electro‐mediated alkylation, arylation, alkynylation, esterification, mercaptoylation, sulfidation, amination ethers have been extensively studied. this review, research progress compounds from 2014 to 2023 systematically reviewed, scope, limitations, mechanisms some reactions discussed.

Language: Английский

Citations

2
Photocatalyst-free visible-light-induced highly selective acylation of purine nucleosides at the C6 position DOI
Luohao Li,

Huiqin Zheng,

Feixiang Guo

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(26), P. 3910 - 3913

Published: Jan. 1, 2023

A protocol for visible-light-induced C-H acylation selectively at the C6 position of purine nucleosides with aldehydes under photocatalyst-free conditions was established herein. This allows green, mild, and efficient functionalization various a broad range alkyl aryl aldehydes.

Language: Английский

Citations

6
Synthesis of 3(2H)-furanone derivatives: p-TsOH/halotrimethylsilane promoted cycloketonization of γ-hydroxyl ynones DOI
Yi‐Feng Qiu,

Jian-He Cao,

Shutao Wang

et al.

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(43), P. 8744 - 8748

Published: Jan. 1, 2023

A halotrimethylsilane facilitated cycloketonization of γ -hydroxyl ynones is detailed for one-step synthesis polysubstituted 3(2 H )-furanone products.

Language: Английский

Citations

6
Photoinduced sulfonylation cyclization to medium-sized benzo[b]azocine and mechanistic insight DOI
Dongyang Zhao, Kai Sun, Miao Tian

et al.

Organic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(13), P. 3313 - 3320

Published: Jan. 1, 2023

A novel light induced 8-endo sulfonyl cyclization to medium-sized benzo[ b ]azocines is developed. DFT calculations rationalize the rate-determining step and chemoselectivity observed in this transformation.

Language: Английский

Citations

5
Regioselective Synthesis of Unsymmetrical Vicinal Diamines via Azidoimination of Alkenes with TMSN3 and Ketimines DOI

Yongzhuo Xu,

Boqiang Wang,

Jiajia Wang

et al.

Organic Letters, Journal Year: 2023, Volume and Issue: 25(48), P. 8716 - 8721

Published: Nov. 22, 2023

2-Azidoimines are versatile precursors to value-added vicinal unsymmetrical diamines, which among the most common motifs in biologically active compounds. Herein, we report their operationally simple synthesis through a highly regioselective intermolecular azidoamination of olefins under metal-free conditions. The approach proceeded azide and iminyl, two differentiated N-centered radicals. synthetic potential protocols was further established via condensation/amination sequential cascade chemoselective, orthogonal transformations access primary diamines.

Language: Английский

Citations

5