Molecular complexes of triterpene glycosides with 5-fluorouracil sodium salt: spectral characterization and cytotoxic activity DOI
Natalya N. Gibadullina, L. A. Yakovishin, V. I. Grishkovets

et al.

Russian Chemical Bulletin, Journal Year: 2024, Volume and Issue: 73(1), P. 179 - 188

Published: Jan. 1, 2024

Language: Английский

Simultaneous Activation of Immunogenic Cell Death and cGAS-STING Pathway by Liver- and Mitochondria-Targeted Gold(I) Complexes for Chemoimmunotherapy of Hepatocellular Carcinoma DOI
Fuwei Li,

Zhenfan Wen,

Chuanxing Wu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(3), P. 1982 - 2003

Published: Jan. 23, 2024

Induction of immunogenic cell death (ICD) and activation the cyclic GMP-AMP synthase stimulator interferon gene (cGAS-STING) pathway are two potent anticancer immunotherapeutic strategies in hepatocellular carcinoma (HCC). Herein, 12 liver- mitochondria-targeting gold(I) complexes (

Language: Английский

Citations

24
Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

Citations

7
An analytical review of the therapeutic application of recent trends in MIL-based delivery systems in cancer therapy DOI
Mohammad Beiranvand, Gholamreza Dehghan

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 16, 2025

Language: Английский

Citations

2
Review targeted drug delivery systems for norcantharidin in cancer therapy DOI Creative Commons

Bingtao Zhai,

Jing Sun, Yajun Shi

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Dec. 3, 2022

Abstract Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD), the main anticancer active ingredient isolated from traditional Chinese medicine Mylabris. NCTD has been approved by State Food and Drug Administration for treatment various solid tumors, especially liver cancer. Although greatly reduces toxicity CTD, there still certain degree urinary organ toxicity, poor solubility, short half-life, fast metabolism, as well high venous irritation weak tumor targeting ability limit its widespread application in clinic. To reduce improve efficacy, design targeted drug delivery systems based on biomaterials nanomaterials one most feasible strategies. Therefore, this review focused studies combined with recent years, including passive systems, physicochemical improving bioavailability enhancing increasing reducing adverse effects. Graphical

Language: Английский

Citations

39
BioMOF-Based Anti-Cancer Drug Delivery Systems DOI Creative Commons
Sandy Elmehrath, Ha L. Nguyen, Sherif M. Karam

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(5), P. 953 - 953

Published: March 6, 2023

A variety of nanomaterials have been developed specifically for biomedical applications, such as drug delivery in cancer treatment. These materials involve both synthetic and natural nanoparticles nanofibers varying dimensions. The efficacy a system (DDS) depends on its biocompatibility, intrinsic high surface area, interconnected porosity, chemical functionality. Recent advances metal-organic framework (MOF) nanostructures led to the achievement these desirable features. MOFs consist metal ions organic linkers that are assembled different geometries can be produced 0, 1, 2, or 3 defining features their outstanding variable functionality, which enable an endless range modalities loading drugs into hierarchical structures. MOFs, coupled with biocompatibility requisites, now regarded highly successful DDSs treatment diverse diseases. This review aims present development applications based chemically-functionalized MOF context concise overview structure, synthesis, mode action MOF-DDS is provided.

Language: Английский

Citations

34
18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control DOI
Junze Jiang,

Xintong Zhou,

Hao Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134319 - 134319

Published: April 21, 2024

Language: Английский

Citations

12
A review of typical biological activities of glycyrrhetinic acid and its derivatives DOI Creative Commons
Liang Chen, Jingwen Gong, Xu Yong

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(10), P. 6557 - 6597

Published: Jan. 1, 2024

Glycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, as well its derivatives produced through structural modification, exhibit noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial, antiviral, and antioxidant effects.

Language: Английский

Citations

10
Mechanisms of Targeted Drug Delivery for Liver Cancer: Active, Passive, and Subcellular Strategies DOI Open Access
Tian Yang, Yu-Sheng Shi

Journal of Biosciences and Medicines, Journal Year: 2025, Volume and Issue: 13(02), P. 369 - 384

Published: Jan. 1, 2025

Language: Английский

Citations

1
Comprehensive insights of etiological drivers of hepatocellular carcinoma: Fostering targeted nano delivery to anti-cancer regimes DOI
Dipanjan Ghosh, Aharna Guin, Ashok Kumar

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189318 - 189318

Published: April 1, 2025

Language: Английский

Citations

1
Dextran-doxorubicin prodrug nanoparticles conjugated with CD147 monoclonal antibody for targeted drug delivery in hepatoma therapy DOI
Hongrui Tian,

Yu Liang,

Mingzu Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 228, P. 113400 - 113400

Published: June 11, 2023

Language: Английский

Citations

18