Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 339 - 353

Published: Feb. 1, 2024

Language: Английский

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Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics

Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2490 - 2525

Published: Jan. 1, 2024

Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.

Language: Английский

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Recent progress on engineered micro/nanomaterials mediated modulation of gut microbiota for treating inflammatory bowel disease

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 43 - 65

Published: April 17, 2024

Language: Английский

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Biocompatible hydrophobic cross-linked cyclodextrin-based metal-organic framework as quercetin nanocarrier for enhancing stability and controlled release

Food Chemistry, Journal Year: 2024, Volume and Issue: 448, P. 139167 - 139167

Published: March 29, 2024

Language: Английский

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Engineering Nanoplatforms for Theranostics of Atherosclerotic Plaques

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: April 2, 2024

Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis

Language: Английский

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Stimulus-Responsive Drug Delivery Nanoplatforms for Inflammatory Bowel Disease Therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Alleviative effects of exopolysaccharides from Limosilactobacillus mucosae CCFM1273 against ulcerative colitis via modulation of gut microbiota and inhibition of Fas/Fasl and TLR4/NF-κB pathways

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129346 - 129346

Published: Jan. 21, 2024

Language: Английский

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Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin

Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 731 - 731

Published: Feb. 5, 2024

The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver targeting drug delivery carrier for oridonin (ORI) in treatment hepatocellular carcinoma (HCC). ASP was reacted with deoxycholic acid (DOCA) via esterification reaction form ASP-DOCA conjugate. ORI-loaded nanoparticles (ORI/ASP-DOCA NPs) were prepared by thin-film water method, and their size about 195 nm aqueous solution. ORI/ASP-DOCA NPs had a loading capacity up 9.2%. release ORI pH-dependent, resulting rapid decomposition accelerated at acidic pH. significantly enhanced accumulation tumors through ASGPR-mediated endocytosis. In vitro results showed that increased cell uptake apoptosis HepG2 cells, vivo caused effective tumor suppression H22 tumor-bearing mice compared free ORI. short, might be simple, feasible, safe nano-drug system could used targeted tumors.

Language: Английский

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Orally administered metal–organic framework nanocubes for sequence-targeted quercetin delivery in colitis alleviation

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160373 - 160373

Published: Feb. 1, 2025

Language: Английский

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Layer-by-layer oral-deliverable nanoparticles targeted microfold cells to promote lutein absorption in alleviating dry eye disease

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147590 - 147590

Published: Nov. 22, 2023

Language: Английский

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