Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

---

Immunogenic Cell Death Augmented by Manganese Zinc Sulfide Nanoparticles for Metastatic Melanoma Immunotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(9), P. 15471 - 15483

Published: Aug. 18, 2022

Both T-cell deprivation and insufficient tumor immunogenicity seriously hinder the efficacy of immune-mediated destruction in melanoma. In this work, an amphiphilic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane) copolymer with a thermally sensitive flowable core (mPEG-b-PHEP) was chosen to incorporate IR780 dye manganese zinc sulfide nanoparticles (ZMS) form polymer micelles (denoted PPIR780-ZMS), which precisely controlled release ZMS after being triggered by near-infrared light (NIR). Mn2+-mediated chemodynamic therapy (CDT) photothermal trigger boosted generation reactive oxygen species (ROS), making PPIR780-ZMS smart bomblets vivo. It demonstrated that could maximize immunogenic cell death (ICD) cancer, is characterized abundant damage-associated molecular pattern (DAMP) exposure. As result, cytotoxic T cells (CD8+) helper (CD4+) expanded infiltrated neoplastic foci, further reprogrammed suppressive microenvironment (TME) against primary pulmonary metastases safe systemic cytokine expression. addition, cGAS-STING signaling pathway activation enhanced antitumor immunity nanocomposite, providing practical strategy for expanding use Mn-based nanostructures.

Language: Английский

---

Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

---

Copper-doped MOF-based nanocomposite for GSH depleted chemo/photothermal/chemodynamic combination therapy

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 438, P. 135567 - 135567

Published: March 1, 2022

Language: Английский

---

Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

Exploration, Journal Year: 2023, Volume and Issue: 3(2)

Published: April 1, 2023

Abstract Functional subcellular organelle mitochondria are emerging as a crucial player and driver of cancer. For maintaining the sites cellular respiration, experience production, accumulation reactive oxygen species (ROS) underlying oxidative damage in electron transport chain carriers. Precision medicine targeting can change nutrient availability redox homeostasis cancer cells, which might represent promising strategy for suppressing tumor growth. Herein, this review highlights how modification capable manipulating nanomaterials ROS generation strategies influence or compensate state mitochondrial homeostasis. We propose foresight to guide research innovation with an overview seminal work discuss future challenges our perspective on commercialization novel mitochondria‐targeting agents.

Language: Английский

---

Tumor Microenvironment-Activable Manganese-Boosted Catalytic Immunotherapy Combined with PD-1 Checkpoint Blockade

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 20400 - 20418

Published: Nov. 28, 2022

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer treatment. Due to the low immunogenicity and immune suppression state tumor microenvironment (TME), therapeutic effects are only moderate. Herein, a TME-activable manganese-boosted catalytic immunotherapy is designed for synergism with ICB kill tumors efficiently. The cell membrane (CM)-wrapping multienzyme-mimic manganese oxide (MnOx) nanozyme termed CM@Mn showed intrinsic peroxidase oxidase-like activities an acidic TME. These can generate toxic hydroxyl (•OH) superoxide radicals (•O2-) killing evoking immunogenic death (ICD). Furthermore, TME-responsive release of Mn2+ directly promotes dendritic maturation macrophage M1 repolarization, resulting reversal immunosuppressive TME into immune-activating environment. Additionally, hypoxia relief caused by catalase-like activity also contributes process reversal. Finally, robust tumor-specific T cell-mediated antitumor response occurs support PD-1 blockade. proliferation primary metastatic was inhibited, long-term memory effect induced. strategy outlined here may serve as promising candidate tumor-integrated

Language: Английский

---

Reactive oxygen species-powered cancer immunotherapy: Current status and challenges

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 623 - 648

Published: March 21, 2023

Language: Английский

---

Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 488, P. 215153 - 215153

Published: April 27, 2023

Language: Английский

---

Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 480, P. 215027 - 215027

Published: Jan. 16, 2023

Language: Английский

---

Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Nano Letters, Journal Year: 2024, Volume and Issue: 24(4), P. 1284 - 1293

Published: Jan. 17, 2024

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded sorafenib (SRF). The spatial isolation Fe3O4@DMS PDA@MnO2-SRF subunits enhances synergistic effect between GSH-scavengers ferroptosis-related components. First, increased exposure subunit Fenton reaction, leading to production reactive oxygen species. Furthermore, effectively depletes GSH, thereby inducing inactivation glutathione-dependent peroxidases 4. Moreover, SRF blocks Xc– transport augmenting GSH depletion capabilities. dual Fe3O4@DMS&PDA@MnO2-SRF significantly weakens antioxidative system, boosting chemodynamic performance cells.

Language: Английский

---