ACS Biomaterials Science & Engineering,
Journal Year:
2023,
Volume and Issue:
9(2), P. 821 - 830
Published: Feb. 1, 2023
Despite
its
promising
potential
in
cancer
treatment,
synergistic
photothermal/chemodynamic
therapy
remains
underdeveloped
with
regard
to
the
utilization
of
metal-organic
materials
under
second
near-infrared
(NIR-II)
laser
excitation.
Herein,
we
report
a
three-dimensional
network
constructed
via
metal
coordination
between
catechol-functionalized
aza-boron
dipyrromethenes
and
iron
ions
(ABFe),
which
was
further
encapsulated
by
F127
obtain
ABFe
nanoparticles
(NPs)
for
combined
therapy.
NPs
exhibited
intense
absorption
NIR-II
range
negligible
fluorescence.
Upon
1064
nm
irradiation,
showed
high
photothermal
conversion
efficiency
(PCE
=
55.0%)
excellent
stability.
The
results
electron
spin
resonance
spectra
o-phenylenediamine
chromaticity
spectrophotometry
proved
that
were
capable
generating
harmful
reactive
oxygen
species
from
hydrogen
peroxide
chemodynamic
therapy,
promoted
performance.
Notably,
vitro
vivo
experiments
demonstrated
great
photoacoustic
imaging
photothermal-enhanced
irradiation.
Therefore,
current
work
presents
prospective
excitation
therapeutic
nanomedicine
combination
offering
novel
strategy
simultaneously
achieving
extended
NIR
aza-BODIPY
enhanced
materials.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: March 7, 2022
Chemodynamic
therapy
(CDT)
has
emerged
to
be
a
frontrunner
amongst
reactive
oxygen
species-based
cancer
treatment
modalities.
CDT
utilizes
endogenous
H
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(9), P. 15471 - 15483
Published: Aug. 18, 2022
Both
T-cell
deprivation
and
insufficient
tumor
immunogenicity
seriously
hinder
the
efficacy
of
immune-mediated
destruction
in
melanoma.
In
this
work,
an
amphiphilic
polyethylene
glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
copolymer
with
a
thermally
sensitive
flowable
core
(mPEG-b-PHEP)
was
chosen
to
incorporate
IR780
dye
manganese
zinc
sulfide
nanoparticles
(ZMS)
form
polymer
micelles
(denoted
PPIR780-ZMS),
which
precisely
controlled
release
ZMS
after
being
triggered
by
near-infrared
light
(NIR).
Mn2+-mediated
chemodynamic
therapy
(CDT)
photothermal
trigger
boosted
generation
reactive
oxygen
species
(ROS),
making
PPIR780-ZMS
smart
bomblets
vivo.
It
demonstrated
that
could
maximize
immunogenic
cell
death
(ICD)
cancer,
is
characterized
abundant
damage-associated
molecular
pattern
(DAMP)
exposure.
As
result,
cytotoxic
T
cells
(CD8+)
helper
(CD4+)
expanded
infiltrated
neoplastic
foci,
further
reprogrammed
suppressive
microenvironment
(TME)
against
primary
pulmonary
metastases
safe
systemic
cytokine
expression.
addition,
cGAS-STING
signaling
pathway
activation
enhanced
antitumor
immunity
nanocomposite,
providing
practical
strategy
for
expanding
use
Mn-based
nanostructures.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(2)
Published: April 1, 2023
Abstract
Functional
subcellular
organelle
mitochondria
are
emerging
as
a
crucial
player
and
driver
of
cancer.
For
maintaining
the
sites
cellular
respiration,
experience
production,
accumulation
reactive
oxygen
species
(ROS)
underlying
oxidative
damage
in
electron
transport
chain
carriers.
Precision
medicine
targeting
can
change
nutrient
availability
redox
homeostasis
cancer
cells,
which
might
represent
promising
strategy
for
suppressing
tumor
growth.
Herein,
this
review
highlights
how
modification
capable
manipulating
nanomaterials
ROS
generation
strategies
influence
or
compensate
state
mitochondrial
homeostasis.
We
propose
foresight
to
guide
research
innovation
with
an
overview
seminal
work
discuss
future
challenges
our
perspective
on
commercialization
novel
mitochondria‐targeting
agents.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(12), P. 20400 - 20418
Published: Nov. 28, 2022
Immune
checkpoint
blockade
(ICB)
therapy
has
attracted
widespread
attention
in
cancer
treatment.
Due
to
the
low
immunogenicity
and
immune
suppression
state
tumor
microenvironment
(TME),
therapeutic
effects
are
only
moderate.
Herein,
a
TME-activable
manganese-boosted
catalytic
immunotherapy
is
designed
for
synergism
with
ICB
kill
tumors
efficiently.
The
cell
membrane
(CM)-wrapping
multienzyme-mimic
manganese
oxide
(MnOx)
nanozyme
termed
CM@Mn
showed
intrinsic
peroxidase
oxidase-like
activities
an
acidic
TME.
These
can
generate
toxic
hydroxyl
(•OH)
superoxide
radicals
(•O2-)
killing
evoking
immunogenic
death
(ICD).
Furthermore,
TME-responsive
release
of
Mn2+
directly
promotes
dendritic
maturation
macrophage
M1
repolarization,
resulting
reversal
immunosuppressive
TME
into
immune-activating
environment.
Additionally,
hypoxia
relief
caused
by
catalase-like
activity
also
contributes
process
reversal.
Finally,
robust
tumor-specific
T
cell-mediated
antitumor
response
occurs
support
PD-1
blockade.
proliferation
primary
metastatic
was
inhibited,
long-term
memory
effect
induced.
strategy
outlined
here
may
serve
as
promising
candidate
tumor-integrated
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(4), P. 1284 - 1293
Published: Jan. 17, 2024
Despite
its
effectiveness
in
eliminating
cancer
cells,
ferroptosis
is
hindered
by
the
high
natural
antioxidant
glutathione
(GSH)
levels
tumor
microenvironment.
Herein,
we
developed
a
spatially
asymmetric
nanoparticle,
Fe3O4@DMS&PDA@MnO2-SRF,
for
enhanced
ferroptosis.
It
consists
of
two
subunits:
Fe3O4
nanoparticles
coated
with
dendritic
mesoporous
silica
(DMS)
and
PDA@MnO2
(PDA:
polydopamine)
loaded
sorafenib
(SRF).
The
spatial
isolation
Fe3O4@DMS
PDA@MnO2-SRF
subunits
enhances
synergistic
effect
between
GSH-scavengers
ferroptosis-related
components.
First,
increased
exposure
subunit
Fenton
reaction,
leading
to
production
reactive
oxygen
species.
Furthermore,
effectively
depletes
GSH,
thereby
inducing
inactivation
glutathione-dependent
peroxidases
4.
Moreover,
SRF
blocks
Xc–
transport
augmenting
GSH
depletion
capabilities.
dual
Fe3O4@DMS&PDA@MnO2-SRF
significantly
weakens
antioxidative
system,
boosting
chemodynamic
performance
cells.
