Engineering Antimicrobial Metal–Phenolic Network Nanoparticles with High Biocompatibility for Wound Healing

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Nov. 24, 2023

Antibiotic-resistant bacteria pose a global health threat by causing persistent and recurrent microbial infections. To address this issue, antimicrobial nanoparticles (NPs) with low drug resistance but potent bactericidal effects have been developed. However, many of the developed NPs display poor biosafety their synthesis often involves complex procedures modes action are unclear. Herein, simple strategy is reported for designing metal-phenolic network (am-MPN) through one-step assembly seeding agent (diethyldithiocarbamate), natural polyphenols, metal ions (e.g., Cu

Language: Английский

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

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Multifunctional Dual Network Hydrogel Loaded with Novel Tea Polyphenol Magnesium Nanoparticles Accelerates Wound Repair of MRSA Infected Diabetes

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 6, 2024

Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infection, caused by impaired glucose metabolism in diabetic foot patients, poses a significant obstacle to the healing process and carries high risk of being life‐threatening. Due microvascular occlusion entrenchment MRSA biofilms foot, controlling effectively treating infection remains challenging. Traditional hydrogels suffer from swelling‐related mechanical issues inadequate drug release control, limiting their applications as biomimetic extracellular matrices for wound healing. Herein, double‐network hydrogel composed polyvinyl alcohol, sodium alginate, gelatin (PSG) loaded with tea polyphenol self‐assembled magnesium nanoparticles (TP‐Mg NPs) antibacterial angiogenic properties MRSA‐infected wounds under hyperglycemic conditions is constructed. TP‐Mg@PSG exhibits enhanced strength toughness attachment recovery movement torsion. In acidic microenvironment representative wounds, degrades TP‐Mg NPs, showing excellent anti‐MRSA effect biocompatibility. Such localized controlled enhances inhibition reduces inflammatory response rats, promoting cell proliferation rapid repair. Therefore, this study presents multifunctional biomaterial system managing conditions, highlighting its potential clinical applications.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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3D‐Printed Tissue‐Specific Nanospike‐Based Adhesive Materials for Time‐Regulated Synergistic Tumor Therapy and Tissue Regeneration In Vivo

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: June 26, 2024

Abstract The growing concerns regarding cancer recurrence, unpredictable bone deficiencies, and postoperative bacterial infections subsequent to the surgical removal of tumors have highlighted need for multifaceted scaffolds that afford tumor therapy, effective vascularized reconstruction. However, challenging trilemma has emerged in realm balance between achieving appropriate mechanical strength, ensuring biocompatibility, optimizing a degradation rate aligns with bone‐regenerative rate. Considering these challenges, innovative theragenerative platform is developed by utilizing 3D printing‐based nanospikes first time. This comprises tissue‐specific nanospiked hydroxyapatite decorated magnesium (nMg) adhesive DNA (aDNA). incorporation nMg within polylactic acid (PLA) matrix confers photothermal capabilities helps modulate properties improve biocompatibility platform. Simultaneously, immobilized aDNA contributed enhancement healing. These 3D‐printed tissue‐adhesive platforms exhibit superior offer controlled degradability. Moreover, they enable eradication bacteria osteosarcoma through hyperthermia promote angiogenesis osteogenesis, both vitro vivo. groundbreaking approach poised pave way fabrication design novel implantable biomaterials integrate therapeutic regenerative functions.

Language: Английский

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Nanozybiotics: Advancing Antimicrobial Strategies Through Biomimetic Mechanisms

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)

Published: June 14, 2024

Infectious diseases caused by bacterial, viral, and fungal pathogens present significant global health challenges. The rapid emergence of antimicrobial resistance exacerbates this issue, leading to a scenario where effective antibiotics are increasingly scarce. Traditional antibiotic development strategies proving inadequate against the swift evolution microbial resistance. Therefore, there is an urgent need develop novel with mechanisms distinct from those existing antibiotics. Nanozybiotics, which nanozyme-based antimicrobials, mimic catalytic action lysosomal enzymes in innate immune cells kill infectious pathogens. This review reinforces concept nanozymes provides comprehensive summary recent research advancements on potential candidates. Initially, nanozybiotics categorized based their activities, mimicking either oxidoreductase-like or hydrolase-like functions, thereby highlighting superior combating then discusses progress treating infections, confirming as translational nanozybiotic-based products, including hydrogels, nanorobots, sprays, bandages, masks, protective clothing, also considered. Finally, current challenges future prospects nanozybiotic-related products explored, emphasizing design capabilities for applications.

Language: Английский

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Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 100, P. 106617 - 106617

Published: Sept. 23, 2023

The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.

Language: Английский

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Surface-Confined Piezocatalysis Inspired by ROS Generation of Mitochondria Respiratory Chain for Ultrasound-Driven Noninvasive Elimination of Implant Infection

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9415 - 9428

Published: May 3, 2023

Implant-associated infections (IAI) are great challenges to medical healthcare and human wellness, yet current clinical treatments limited the use of antibiotics physical removal infected tissue or implant. Inspired by protein/membrane complex structure its generation reactive oxygen species in mitochondria respiration process immune cells during bacteria invasion, we herein propose a metal/piezoelectric nanostructure embedded on polymer implant surface achieve efficient piezocatalysis for combating IAI. The piezoelectricity-enabled local electron discharge induced oxidative stress generated at implant–bacteria interface can efficiently inhibit activity attachedStaphylococcus aureusby cell membrane disruption sugar energy exhaustion, possess high biocompatibility, eliminate subcutaneous infection simply applying ultrasound stimulation. For further demonstration, treatment root canal reinfection with simplified procedures has been achieved using piezoelectric gutta-percha implanted ex vivo teeth. This surface-confined antibacterial strategy, which takes advantage interspace, easiness processing, noninvasiveness sonodynamic therapy, potential applications IAI treatment.

Language: Английский

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Antibacterial and Angiogenic (2A) Bio‐Heterojunctions Facilitate Infectious Ischemic Wound Regeneration via an Endogenous–Exogenous Bistimulatory Strategy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Oct. 18, 2023

Abstract In infectious ischemic wounds, a lack of blood perfusion significantly worsens microbe‐associated infection symptoms and frequently complicates healing. To overcome this daunting issue, antibacterial angiogenic (2A) bio‐heterojunctions (bio‐HJs) consisting CuS/MXene heterojunctions vascular endothelial growth factor (VEGF)‐mimicking peptide (VMP) are devised developed to accelerate cutaneous regeneration by boosting angiogenesis via an endogenous–exogenous bistimulatory (EEB) strategy. Assisted near‐infrared irradiation, the bio‐HJ platform exhibits versatile synergistic photothermal, photodynamic, chemodynamic effects for robust efficacy. addition, copper ions liberated from 2A bio‐HJs elevate VEGF secretion fibroblasts, which provokes receptors (VEGFR) activation through endogenous pathway, whereas VMP itself promotes exogenous pathway facilitate cell multiplication tube formation directly activating VEGFR signaling pathway. Moreover, employing in vivo model it is confirmed that EEB strategy can considerably boost pathogen elimination, promotion, collagen deposition. As envisaged, work leads development powerful serve as effective remedy bacterial invasion‐induced wounds

Language: Английский

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Antibacterial black phosphorus nanosheets for biomedical applications

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(30), P. 7069 - 7093

Published: Jan. 1, 2023

This review highlights the potential of black phosphorus nanosheets (BPNs) in treating bacterial infections, addressing their unique properties as well challenges and prospects antibacterial applications biomedicine.

Language: Английский

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