MOFs and MOF-Derived Materials for Antibacterial Application

Journal of Functional Biomaterials, Journal Year: 2022, Volume and Issue: 13(4), P. 215 - 215

Published: Nov. 3, 2022

Bacterial infections pose a serious threat to people’s health. Efforts are being made develop antibacterial agents that can inhibit bacterial growth, prevent biofilm formation, and kill bacteria. In recent years, materials based on metal organic frameworks (MOFs) have attracted significant attention for various applications due their high specific surface area, enzyme-like activity, continuous release of ions. This paper reviews the progress MOFs as agents, focusing preparation methods, fundamental mechanisms, strategies enhance effects. Finally, several prospects related application proposed, aiming provide possible research directions in this field.

Language: Английский

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Stimuli responsive nanosonosensitizers for sonodynamic therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 547 - 567

Published: Aug. 15, 2023

Language: Английский

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Guanidinium‐Decorated Nanostructure for Precision Sonodynamic‐Catalytic Therapy of MRSA‐Infected Osteomyelitis

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(50)

Published: Oct. 17, 2022

Osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection is difficult to eradicate and can even be life-threatening. Given that the persistent deep-seated in bone tissue, controlled efficient treatment of osteomyelitis remains challenging. Herein, an activatable nanostructure (Au/TNT@PG) presented for synergistic sonodynamic-catalytic therapy MRSA-infected osteomyelitis. The Au/TNT@PG backbone obtained conjugating a guanidinium-rich polymer (PG), component penetrates matrix, onto ultrasound (US)-absorbing gold-doped titanate nanotubes (Au/TNTs). Under deep-penetrating US irradiation, nanocomposite generates 1 O2 sonodynamic catalyzes decomposition endogenous H2 into toxic •OH acidic microenvironment catalytic therapy, leading bacterial cell death. Its robust antibacterial effectiveness attributable its bacteria-capturing ability, penetrability positively charged guanidinium, subsequent effect action Au/TNT. Such remotely approach potentiates polarization macrophages M2-type while suppressing M1-type, topical inflammation resolution enhanced osteoblast proliferation differentiation inhibit loss. Therefore, this study provides generic nanotherapeutic with respect

Language: Английский

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Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity

Small, Journal Year: 2023, Volume and Issue: 19(42)

Published: June 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Language: Английский

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Single Atom‐Doped Nanosonosensitizers for Mutually Optimized Sono/Chemo‐Nanodynamic Therapy of Triple Negative Breast Cancer

Advanced Science, Journal Year: 2023, Volume and Issue: 10(6)

Published: Jan. 16, 2023

Sonodynamic therapy (SDT) represents a promising therapeutic modality for treating breast cancer, which relies on the generation of abundant reactive oxygen species (ROS) to induce oxidative stress damage. However, mutant cancers, especially triple-negative cancer (TNBC), have evolved acquire specific antioxidant defense functions, significantly limiting killing efficiency SDT. Herein, authors engineered distinct single copper atom-doped titanium dioxide (Cu/TiO2 ) nanosonosensitizer with highly catalytic and sonosensitive activities synergistic chemodynamic sonodynamic treatment TNBC. The single-atom Cu is anchored most stable Ti vacancies hollow TiO2 sonosensitizers, not only substantially improved activity Cu-mediated Fenton-like reaction, but also considerably augmented by facilitating separation electrons (e- holes (h+ ). Both in vitro vivo studies demonstrate that nanosonosensitizers effectively achieved inhibitory effect TNBC, providing paradigm non-invasive safe tumor elimination through mutual process sono/chemo-nanodynamic based multifunctional nanosonosensitizers.

Language: Английский

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Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: April 18, 2023

As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because its ability to penetrate deep tissue with few side effects. key factor SDT, it is meaningful design and synthesize efficient sonosensitizers. Compared organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, stable properties, good dispersion, long blood circulation time, have great development potential SDT. This review summarizes possible mechanisms SDT (sonoexcitation ultrasonic cavitation) detail. Based on these mechanisms, synthesis nanosonosensitizers divided into three categories: traditional semiconductor enhanced cavitation-enhanced Subsequently, current construction methods are summarized including accelerated charge separation production reactive oxygen species through cavitation. Furthermore, advantages disadvantages different detailed strategies systematically discussed how enhance Hopefully, this could provide new insights nano-sonosensitizers for

Language: Английский

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Alternative Copper-Based Single-Atom Nanozyme with Superior Multienzyme Activities and NIR-II Responsiveness to Fight against Deep Tissue Infections

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Nanozymes are considered to represent a new era of antibacterial agents, while their efficiency is limited by the increasing tissue depth infection. To address this issue, here, we report copper and silk fibroin (Cu-SF) complex strategy synthesize alternative single-atom nanozymes (SAzymes) with atomically dispersed sites anchored on ultrathin 2D porous N-doped carbon nanosheets (CuN x -CNS) tunable N coordination numbers in CuN (x = 2 or 4). The -CNS SAzymes inherently possess triple peroxidase (POD)-, catalase (CAT)-, oxidase (OXD)-like activities, facilitating conversion H2O2 O2 into reactive oxygen species (ROS) through parallel POD- OXD-like cascaded CAT- reactions. Compared CuN2-CNS, tailoring number from 4 endows SAzyme (CuN4-CNS) higher multienzyme activities due its superior electron structure lower energy barrier. Meanwhile, display strong absorption second near-infrared (NIR-II) biowindow deeper penetration, offering NIR-II-responsive enhanced ROS generation photothermal treatment deep tissues. vitro vivo results demonstrate that optimal CuN4-CNS can effectively inhibit multidrug-resistant bacteria eliminate stubborn biofilms, thus exhibiting high therapeutic efficacy both superficial skin wound implant-related biofilm infections.

Language: Английский

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Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 10, 2023

The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small-molecule photosensitizers. Herein, we report that the reticular chemistry-based synthesis from two inert monomers yields a COF-based sonosensitizer (TPE-NN) inherent activity. Subsequently, nanoscale COF TPE-NN fabricated and embedded copper (Cu)-coordinated sites to obtain TPE-NN-Cu. Results show Cu coordination can enhance effect TPE-NN, whereas ultrasound (US) irradiation for therapy augment chemodynamic efficacy Consequently, TPE-NN-Cu upon US shows high-performance anticancer based on mutually reinforced sono-/chemo-nanodynamic therapy. This study reveals backbone-originated activity proposes paradigm nanodynamic

Language: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100559 - 100559

Published: Jan. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Language: Английский

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Smart stimuli-responsive strategies for titanium implant functionalization in bone regeneration and therapeutics

Materials Horizons, Journal Year: 2023, Volume and Issue: 11(1), P. 12 - 36

Published: Oct. 4, 2023

With the increasing and aging of global population, there is a dramatic rise in demand for implants or substitutes to rehabilitate bone-related disorders which can considerably decrease quality life even endanger lives. Though titanium its alloys have been applied as mainstream material fabricate load-bearing bone defect restoration temporary internal fixation devices fractures, it far from rare encounter failed cases clinical practice, particularly with pathological factors involved. In recent years, smart stimuli-responsive (SSR) strategies conducted functionalize improve regeneration conditions, such bacterial infection, chronic inflammation, tumor diabetes mellitus,

Language: Английский

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