Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

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Multifunctional nanoparticle for cancer therapy

MedComm, Journal Year: 2023, Volume and Issue: 4(1)

Published: Jan. 11, 2023

Cancer is a complex disease associated with combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment diagnosis for cancer, current strategies simultaneously focus on various tumor targets. Based the rapid development nanotechnology, nanocarriers have been shown to exhibit excellent potential cancer therapy. Compared nanoparticles single functions, multifunctional are believed be more aggressive potent context targeting. However, not simply an upgraded version original function, but involves sophisticated system proper backbone, optimized modification sites, simple preparation method, efficient function integration. Despite this, many well-designed promising therapeutic emerged recently. Here, give detailed understanding analyzation currently developed nanoparticles, their platform structures organic or inorganic backbones were systemically generalized. We emphasized functionalization strategies, which additional functions nanoparticle. also discussed application that involved nanoformulations functional crosstalk. This review thus provides overview construction advances nanoparticles.

Language: Английский

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A Strategy of Fenton Reaction Cycloacceleration for High‐Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 9, 2023

Abstract The emerging tumor ferroptosis therapy confronts impediments of the microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H 2 O , and a powerful intracellular redox balance system that eliminates toxic reactive oxygen species (ROS). Herein, strategy Fenton reaction cycloacceleration initiated by remodeling TME for magnetic resonance imaging (MRI)‐guided high‐performance tumors is proposed. synthesized nanocomplex exhibits enhanced accumulation at carbonic anhydrase IX (CAIX)‐positive based on CAIX‐mediated active targeting, increased acidification via inhibition CAIX 4‐(2‐aminoethyl) benzene sulfonamide (ABS) (remodeling TME). This accumulated + abundant glutathione in synergistically trigger biodegradation to release loaded cuprous oxide nanodots (CON), β ‐lapachon (LAP), Fe 3+ gallic acid‐ferric ions coordination networks (GF). Fenton‐like reactions are cycloaccelerated catalytic loop Fe‐Cu, LAP‐triggered nicotinamide adenine dinucleotide phosphate quinone oxidoreductase1‐mediated cycle, generating robust ROS plenitudinous lipid peroxides cells. detached GF network has improved relaxivities response TME. Therefore, promising MRI‐guided tumors.

Language: Английский

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Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO₂ Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12544 - 12562

Published: June 24, 2023

To achieve the maximum therapeutic effects and minimize adverse of trimodal synergistic tumor therapies, a cost-effective programmed photothermal (PTT)-chemodynamic (CDT)-coordinated dual drug chemotherapy (CT) therapy strategy in chronological order is proposed. According to status or volumes tumors, intensity time each modality are optimized, three modalities combined programmatically work order. The optimal begins with high-intensity PTT for 10 min ablate larger followed by medium-intensity CDT several hours eliminate medium-sized then low-intensity coordinated drugs CT lasts over 48 h clear smaller residual tumors. Composite nanoparticles, made Fe-coordinated polydopamine mixed copper peroxide as cores their surface dotted lots doxorubicin-Fe(III)-gossypol infinite coordination polymers (ICPs), have been developed implement strategy. These composite nanoparticles show excellent minimum dose agents result nearly 100% inhibition mice bearing PC-3 tumors no observed recurrence within 60 days treatment. ratios different can be adjusted accommodate types this

Language: Английский

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Cellular Trojan Horse initiates bimetallic Fe-Cu MOF-mediated synergistic cuproptosis and ferroptosis against malignancies

Science Advances, Journal Year: 2024, Volume and Issue: 10(15)

Published: April 10, 2024

Disruptions in metal balance can trigger a synergistic interplay of cuproptosis and ferroptosis, offering promising solutions to enduring challenges oncology. Here, we have engineered Cellular Trojan Horse, named MetaCell, which uses live neutrophils stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs (Lip@Fe-Cu-MOFs). MetaCell instigate thereby enhancing treatment efficacy. Mirroring the characteristics neutrophils, evade immune system not only infiltrate tumors but also respond inflammation by releasing therapeutic components, surmounting traditional barriers. Notably, Lip@Fe-Cu-MOFs demonstrate notable photothermal effects, inciting targeted release Fe-Cu-MOFs within cancer cells amplifying action ferroptosis. has demonstrated outcomes tumor-bearing mice, effectively eliminating solid forestalling recurrence, leading extended survival. This research provides great insights into complex between copper iron homeostasis malignancies, potentially paving way for innovative approaches treatment.

Language: Английский

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Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(4)

Published: April 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Language: Английский

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An Intelligent Cupreous Nanoplatform with Self-Supplied H₂O₂ and Cu²⁺/Cu⁺ Conversion to Boost Cuproptosis and Chemodynamic Combined Therapy

Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(2), P. 815 - 828

Published: Jan. 11, 2024

Cuproptosis is a newly identified copper-dependent cell death and holds great promise for cancer therapy. However, transporting enough copper into cells challenge. Herein, an intelligent cupreous nanoplatform (denoted as CuO2-MSN@TA-Cu2+), consisting of in situ formation CuO2 within mesoporous silica nanoparticles (MSN) then deposition with tannic acid (TA)-Cu2+ complex, designed developed to realize on-demand delivery cuproptosis-based combination CuO2-MSN@TA-Cu2+ exhibits tumor microenvironment-triggered therapeutic activity, wherein the outer TA-Cu2+ complex readily disassembled release Cu2+ liberate internal produce H2O2. The overloaded can not only directly convert endogenous H2O2 self-supplied highly toxic hydroxyl radicals chemodynamic therapy (CDT) via Cu-based Fenton-like reaction but also undergo glutathione-mediated reduction Cu+ species induce potent cellular cuproptosis enhance CDT. experimental results indicate that produces remarkable cytotoxicity against significantly suppresses growth by 93.42% mice-bearing 4T1 breast tumors. This work provides new paradigm boost cuproptosis-related may inspire design advanced nanoplatforms.

Language: Английский

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Dendrimer/metal-phenolic nanocomplexes encapsulating CuO2 for targeted magnetic resonance imaging and enhanced ferroptosis/cuproptosis/chemodynamic therapy by regulating the tumor microenvironment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 183, P. 252 - 263

Published: May 25, 2024

Language: Английский

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Graphene quantum dots as metal-free nanozymes for chemodynamic therapy of cancer

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 977 - 990

Published: Jan. 10, 2024

Language: Английский

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