Small,
Journal Year:
2023,
Volume and Issue:
20(19)
Published: Dec. 6, 2023
Abstract
The
occurrence
of
osteoarthritis
(OA)
is
highly
associated
with
the
inflammatory
hypoxic
microenvironment.
Yet
currently
no
attention
has
been
paid
to
fabricating
hypoxia‐responsive
platforms
for
OA
treatment.
Herein,
an
injectable
hydrogel
microsphere
system
(HAM‐SA@HCQ)
focusing
on
inflamed
joint
prepared
methacrylate‐modified
sulfonated
azocalix[4]arene
(SAC4A‐MA),
methacrylated
hyaluronic
acid
(HA‐MA),
and
dithiol‐terminated
matrix
metalloproteinase
13
(MMP‐13)
sensitive
peptide
via
a
microfluidic
device
photo
crosslinking
technique,
followed
by
encapsulation
anti‐inflammatory
drug
hydroxychloroquine
(HCQ)
through
host–guest
interaction.
Owing
hydrophobic
deep
cavity,
phenolic
units,
azo
bonds
SAC4A‐MA,
microspheres
show
strong
loading
capacity,
prominent
reactive
oxygen
species
(ROS)
scavenging
capability,
specific
release
ability.
In
tissue
microenvironment,
undergo
degradation
excessive
MMP‐13
HCQ
under
hypoxia
condition,
which
synergizes
ROS‐scavenging
calixarene
inhibit
response
macrophages.
After
being
injected
into
OA‐inflamed
joint,
HAM‐SA@HCQ
can
significantly
attenuate
oxidative
stress,
downregulate
expression
hypoxia‐induced
factor‐1α
cytokines,
prevent
cartilage
from
destroyed.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(31), P. 20101 - 20110
Published: July 23, 2024
Osteoarthritis
(OA)
is
a
prevalent
degenerative
disease
that
afflicts
more
than
250
million
people
worldwide,
impairing
their
mobility
and
quality
of
life.
However,
conventional
drug
therapy
palliative.
Exosomes
(Exo),
although
with
the
potential
to
fundamentally
repair
cartilage,
face
challenges
in
efficient
enrichment
delivery.
In
this
study,
we
developed
magnetic
polysaccharide
hydrogel
particles
as
microcarriers
for
synergistic
OA.
The
were
composed
modified
natural
polysaccharides,
hyaluronic
acid
(HAMA),
chondroitin
sulfate
(CSMA),
generated
from
microfluidic
electrospray
combination
cryogelation
process.
Magnetic
nanoparticles
spiny
structures
capable
capturing
stem
cell
Exo
encapsulated
within
together
an
anti-inflammatory
diclofenac
sodium
(DS).
released
DS
had
effect
alleviating
OA
symptoms
promoting
cartilage
repair.
vitro
vivo
results
demonstrated
excellent
performance
microcarrier
treatment.
We
believe
work
has
other
related
diseases.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
18, P. 100530 - 100530
Published: Dec. 28, 2022
In
view
of
their
low
immunogenicity,
biomimetic
internal
environment,
tissue-
and
organ-like
physicochemical
properties,
functionalization
potential,
decellularized
extracellular
matrix
(dECM)
materials
attract
considerable
attention
are
widely
used
in
tissue
engineering.
This
review
describes
the
composition
matrices
role
stem-cell
differentiation,
discusses
advantages
disadvantages
existing
decellularization
techniques,
presents
methods
for
characterization
scaffolds.
addition,
we
discuss
progress
use
dECMs
cartilage,
skin,
nerve,
muscle
repair
transplantation
or
regeneration
different
whole
organs
(e.g.,
kidneys,
liver,
uterus,
lungs,
heart),
summarize
shortcomings
using
organ
after
refunctionalization,
examine
corresponding
future
prospects.
Thus,
present
helps
to
further
systematize
application
functionalized
tissue/organ
keep
researchers
up
date
on
recent
dECM
usage.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
16, P. 100394 - 100394
Published: Aug. 13, 2022
Sustained-release
drug-loaded
microspheres
provide
a
long-acting
sustained
release,
with
targeted
and
other
effects.
There
are
many
types
of
sustained-release
drug
various
preparation
methods,
they
easy
to
operate.
For
these
reasons,
have
attracted
widespread
interest
widely
used
in
tissue
engineering
fields.
In
this
paper,
we
systematic
review
the
application
engineering.
First,
introduce
new
type
delivery
system
(sustained-release
carriers),
describe
microspheres,
summarize
characteristics
different
microspheres.
Second,
methods
materials
required
for
preparing
Third,
applications
summarized.
Finally,
shortcomings
discuss
future
prospects
development
The
purpose
paper
was
further
understanding
personnel
engaged
related
fields
inspiration
ideas
studies
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
17, P. 81 - 108
Published: Jan. 25, 2022
Successful
regeneration
of
cartilage
tissue
at
a
clinical
scale
has
been
tremendous
challenge
in
the
past
decades.
Microcarriers
(MCs),
usually
used
for
cell
and
drug
delivery,
have
studied
broadly
across
wide
range
medical
fields,
especially
engineering
(TE).
Notably,
microcarrier
systems
provide
an
attractive
method
regulating
phenotype
microtissue
maturations,
they
also
serve
as
powerful
injectable
carriers
are
combined
with
new
technologies
regeneration.
In
this
review,
we
introduced
typical
methods
to
fabricate
various
types
microcarriers
discussed
appropriate
materials
microcarriers.
Furthermore,
highlighted
recent
progress
applications
general
design
principle
Finally,
summarized
current
challenges
promising
prospects
microcarrier-based
applications.
Overall,
review
provides
comprehensive
systematic
guidelines
rational
TE.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(41)
Published: Aug. 5, 2022
Abstract
In
recent
decades,
artificial
nerve
scaffolds
have
become
a
promising
substitute
for
peripheral
repair.
Considerable
efforts
been
devoted
to
improving
the
therapeutic
effectiveness
of
scaffolds.
Among
numerous
biomaterials
tissue
engineering
fabrication,
natural
polymers
are
considered
as
tremendous
candidates
because
their
excellent
biocompatibility,
low
toxicity,
high
cell
affinity,
wide
source,
and
environmental
protection.
With
development
technology,
variety
polymer‐derived
emerged,
which
endowed
with
biological
properties
appropriate
physicochemical
performances
gradually
adapt
needs
regeneration.
Significantly,
intergradation
exogenous
biomolecules
onto
is
able
avoid
stability,
rapid
degradation,
redistribution
direct
drugs
in
vivo,
thereby
enhancing
regeneration
functional
reconstruction.
Here,
derived
from
polymers,
applications
continuous
administration
comprehensively
carefully
reviewed,
providing
an
advanced
perspective
field.
