Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Copper
plays
a
pivotal
role
in
human
physiology,
particularly
oncology,
acting
both
as
facilitator
of
progression
and
also
potential
avenue
for
advanced
therapeutic
approaches.
Maintaining
copper
homeostasis
is
crucial.
The
dysregulation
implicated
tumor
growth
through
its
involvement
critical
processes
angiogenesis,
proliferation,
metastasis.
elevation
level
the
microenvironment
(TME)
activates
oncogenic
pathways
to
drive
neovascularization
sustained
malignancies.
However,
same
reliance
on
offers
unique
weakness
that
can
be
leveraged
innovative
interventions.
recent
advances
nanomedicine
enable
synthesis
nanostructures
help
modulate
with
precision
offering
multifaceted
approaches
copper‐based
cancer
therapy
controlled
release
mechanism,
optimized
structures
induce
cuproptosis,
selective
eradication
cells
minimum
systemic
toxicity.
This
review
explores
dual
biology,
emphasizing
contribution
tumors
emerging
application
targeted
therapy.
highlights
harnessing
therapies
their
transformative
from
bench
bed
side
novel,
highly
effective,
clinical
safety.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(8)
Published: Oct. 11, 2023
Abstract
Activating
the
strong
immune
system
is
a
key
initiative
to
counteract
dormant
tumors
and
prevent
recurrence.
Herein,
self‐destructive
multienzymatically
active
copper‐quinone‐GOx
nanoparticles
(abbreviated
as
CQG
NPs)
have
been
designed
induce
harmonious
balanced
pyroptosis
cuproptosis
using
“Tai
Chi
mindset”
awaken
response
for
suppressing
recurrent
tumors.
This
cleverly
material
can
disrupt
antioxidant
defense
mechanism
of
tumor
cells
by
inhibiting
nuclear
factor‐erythroid
2‐related
factor
2
(NRF2)‐quinone
oxidoreductase
1
(NQO1)
signaling
pathway.
Furthermore,
combined
with
its
excellent
multienzyme
activity,
it
activates
NOD‐like
receptor
protein
3
(NLRP3)‐mediated
pyroptosis.
Meanwhile,
be
triggered
copper
ions
released
from
disintegration
NPs
sensitivity
cancer
enhanced
through
depletion
endogenous
chelators
via
Michael
addition
reaction
between
glutathione
(GSH)
quinone
ligand,
oxygen
production
catalase‐like
reaction,
starvation‐induced
glucose
deficiency.
More
importantly,
NPs‐induced
promote
immunosuppressive
microenvironment
(TME)
remodeling,
enhance
infiltration
into
tumor,
activate
robust
systemic
immunity.
Collectively,
this
study
provides
new
strategy
resist
dormancy,
recurrence,
improve
clinical
prognosis
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(20), P. 19581 - 19599
Published: Oct. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(23)
Published: April 6, 2024
Abstract
Cuproptosis
is
a
newly
discovered
form
of
programmed
cell
death
significantly
depending
on
the
transport
efficacy
copper
(Cu)
ionophores.
However,
existing
Cu
ionophores,
primarily
small
molecules
with
short
blood
half‐life,
face
challenges
in
transporting
enough
amounts
ions
into
tumor
cells.
This
work
describes
construction
carrier‐free
nanoparticles
(Ce6@Cu
NPs),
which
self‐assembled
by
coordination
2+
sonosensitizer
chlorin
e6
(Ce6),
facilitating
sonodynamic‐triggered
combination
cuproptosis
and
ferroptosis.
Ce6@Cu
NPs
internalized
U87MG
cells
induce
sonodynamic
effect
glutathione
(GSH)
depletion
capability,
promoting
lipid
peroxidation
eventually
inducing
Furthermore,
+
concentration
increases
as
reacts
reductive
GSH,
resulting
downregulation
ferredoxin‐1
lipoyl
synthase.
induces
oligomerization
lipoylated
dihydrolipoamide
S‐acetyltransferase,
causing
proteotoxic
stress
irreversible
cuproptosis.
possess
satisfactory
ability
to
penetrate
blood‐brain
barrier,
significant
accumulation
orthotopic
U87MG‐Luc
glioblastoma.
The
ferroptosis
evidenced
both
vitro
vivo
minimal
side
effects.
represents
promising
therapeutic
strategy
combining
cuproptosis,
potentially
inspiring
further
research
developing
logical
effective
cancer
therapies
based
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: Feb. 23, 2024
Abstract
Autophagy,
a
lysosome‐involved
degradation
pathway,
as
self‐protective
cellular
process,
always
weakens
the
efficiency
of
tumor
therapies.
Herein,
for
first
time,
biodegradable
copper
(Cu)
ions
doped
layered
double
hydroxide
(Cu‐LDH)
nanoparticles
are
reported
cancer
immunotherapy
via
lysosomal
rupture‐mediated
“Broken
Window
Effect”.
Only
injection
Cu‐LDH
single
therapeutic
agent
achieves
various
organelles
destruction
after
rupture,
well
abnormal
aggregation
Cu
in
cells
cuproptosis
and
pyroptosis.
More
importantly,
autophagy
inhibition
caused
by
rupture
improves
overload‐mediated
pyroptosis
blocking
lysosome‐mediated
bulk
leading
to
good
anti‐tumor
immune
responses
ultimately
high‐efficiency
growth
inhibition.
This
Effect”
provides
new
paradigm
enhanced
therapy.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: Aug. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 1, 2024
Copper
plays
vital
roles
in
numerous
cellular
processes
and
its
imbalance
can
lead
to
oxidative
stress
dysfunction.
Recent
research
has
unveiled
a
unique
form
of
copper-induced
cell
death,
termed
cuproptosis,
which
differs
from
known
death
mechanisms.
This
process
involves
the
interaction
copper
with
lipoylated
tricarboxylic
acid
cycle
enzymes,
causing
protein
aggregation
death.
Recently,
growing
number
studies
have
explored
link
between
cuproptosis
cancer
development.
review
comprehensively
examines
systemic
metabolism
copper,
including
tumor-related
signaling
pathways
influenced
by
copper.
It
delves
into
discovery
mechanisms
connection
various
cancers.
Additionally,
suggests
potential
treatments
using
ionophores
that
induce
combination
small
molecule
drugs,
for
precision
therapy
specific
types.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(45)
Published: Sept. 17, 2024
Abstract
The
overexpression
of
polyamines
in
tumor
cells
contributes
to
the
establishment
immunosuppressive
microenvironment
and
facilitates
growth.
Here,
it
have
ingeniously
designed
multifunctional
copper‐piceatannol/HA
nanopills
(Cu‐Pic/HA
NPs)
that
effectively
cause
total
intracellular
depletion
by
inhibiting
synthesis,
depleting
polyamines,
impairing
uptake,
resulting
enhanced
pyroptosis
cuproptosis,
thus
activating
a
powerful
immune
response
achieve
anti‐tumor
therapy.
Mitochondrial
dysfunction
from
overall
not
only
leads
surge
copper
ions
mitochondria,
thereby
causing
aggregation
toxic
proteins
induce
but
also
triggers
accumulation
reactive
oxygen
species
(ROS)
within
which
further
upregulates
expression
zDHHC5
zDHHC9
promote
palmitoylation
gasdermin
D
(GSDMD)
GSDMD‐N,
ultimately
inducing
pyroptosis.
Then
occurrence
cuproptosis
is
conductive
remodel
microenvironment,
responses
growth
metastasis.
This
therapeutic
strategy
through
comprehensive
provides
novel
template
for
cancer
immunotherapy.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Oxygen
(O
2
)
tension
within
a
tumor
is
considered
hallmark
of
sonodynamic
therapy
(SDT).
Herein,
multifunctional
nanoregulators,
CMCS‐Au‐SrS
(CAS),
are
reported,
which
assembled
by
carboxymethyl
chitosan(CMCS)
tethered
gold
nanoclusters
(Au
NCs)
as
sonosensitizers
and
sulfurate
donors
strontium
sulfide
nanoparticles
(SrS
NPs),
to
evoke
selective
SDT
in
hypoxic
tumors.
CAS
possess
tumor‐acidity
responsiveness
form
large‐size
aggregated
Au
NCs
with
shortened
bandgap
so
that
effectively
induce
powerful
reactive
oxygen
species
generation.
On
the
other
hand,
acidity
triggers
degradation
SrS
NPs
release
hydrogen
(H
S),
evoking
oxygenation
overcome
hypoxia.
This
junction
accelerated
sonosensiting
ability
boosts
amplified
efficacy.
More
importantly,
specific
glycolysis
induced
acidification
leads
selectively
accumulated
cancer
cells,
further
guaranteeing
execution
advanced
therapeutic
manners.
Additionally,
doping
Nd
3+
endows
second
near‐infrared
fluorescence
facilitate
vivo
tracing
property
good
tissue
penetration
(up
6
mm).
strategy
may
play
pioneering
role
develop
theranostic
reagents
improved
enrichment
capacity
enhanced
hypoxia
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101583 - 101583
Published: Feb. 16, 2025
The
application
of
Nanocarriers
(NCs)
provides
a
promising
strategy
to
solve
the
problems
faced
by
traditional
chemotherapy
drugs,
like
imprecise
delivery,
poor
bioavailability,
high
dose
requirement,
and
tendency
develop
multidrug
resistance.
With
protection
NCs,
drugs
can
reach
lesion
site
then
release
accurately
completely.
Although
some
reviews
have
summarized
biological
applications
little
attention
has
been
given
advantages
disadvantages
analyzing
organic,
inorganic,
hybrid
NCs
separately
for
targeted
therapy
identifying
means
further
improve
targeting
ability.
First,
in
this
review,
we
emphasize
three
factors
that
marked
impact
on
therapy:
tumor
microenvironment
(TME),
different
administration
modalities
(intravenous,
oral,
intracavitary
administration),
pathways
(passive
active).
Second,
systematic
examination
polymeric
dendrimers,
micelles,
liposomes,
mesoporous
silica
gold
quantum
dots,
nano
clay,
core-shell
MOFs
are
reviewed.
Further,
propose
ways
efficiency
therapy,
including
regulating
size,
shape,
surface
properties
NCs.