Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113612 - 113612
Published: March 10, 2025
Language: Английский
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)
Published: June 7, 2023
Abstract Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria‐infected open wounds with conventional measures is problematic. Here, photothermal cascade nano‐reactor (CPNC@GOx‐Fe 2+ ) constructed through supramolecular strategy hydrogen bonding coordination interactions between chitosan‐modified palladium nano‐cube (CPNC), glucose oxidase (GOx), ferrous iron (Fe ). CPNC@GOx‐Fe exhibits excellent effects powers GOx‐assisted reaction generate hydroxyl radicals, enabling chemodynamic combination therapy against biofilms. Further proteomics, metabolomics, all‐atom simulation results indicate that damage radical function structure cell membrane thermal enhance fluidity inhomogeneity bacterial membrane, resulting synergistic antibacterial effect. In biofilm‐associated tooth extraction wound model, generated from process can initiate polymerization form hydrogel situ protection. vivo experiments confirm protection accelerate healing infected tooth‐extraction without affecting oral commensal microbiota. This study provides way propose multifunctional system treatment infection.
Language: Английский
Citations
87
The Innovation, Journal Year: 2023, Volume and Issue: 4(6), P. 100503 - 100503
Published: Aug. 29, 2023
•Insights into the intricate facets of immune microenvironment hold key to pioneering clinical strategies in combatting bacterial infections.•The design principles for antimicrobial biomaterials vary depending on at different stages infection.•Immunomodulatory display robust efficacy and vaccine attributes animals trials, promising intractable infections. Bacterial infectious diseases are one leading causes death worldwide. Even with use multiple antibiotic treatment strategies, 4.95 million people died from drug-resistant infections 2019. By 2050, number deaths will reach 10 annually. The increasing mortality may be partly due heterogeneity infection microenvironment, such as bacteria, biofilms, persister cells, intracellular small colony variants. In addition, complexity makes direct activity unsatisfactory long-term chronic attributed failing modulate active action cells. Therefore, there is an urgent need effective alternatives treat Accordingly, development immunomodulatory has recently received considerable interest; however, a comprehensive review their research progress lacking. this review, we focus mainly future perspectives used infection. First, describe characteristics acute phases Then, highlight corresponding advantages disadvantages. Moreover, discuss biomaterial-mediated vaccines' potential applications challenges activating innate adaptive memory. This serve reference studies develop next-generation accelerate translation practice.
Language: Английский
Citations
70
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)
Published: April 27, 2024
Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.
Language: Английский
Citations
65
BMEMat, Journal Year: 2023, Volume and Issue: 1(3)
Published: July 19, 2023
Abstract Cell therapy has revolutionized the treatment of various diseases, such as cancers, genetic disorders, and autoimmune diseases. Currently, most cell products rely on ex vivo engineering, which requires sophisticated manufacturing processes poses safety concerns. The implementation in situ holds potential to overcome current limitations provides a broad range applications clinical feasibility future. A variety biomaterials have been developed improve function target delivery specific types due their excellent biocompatibility, tunable properties, other functionalities, provide reliable method achieve modulation reprogramming. In this article, we summarize recent advances for including T cells, macrophages, dendritic stem cells reprogramming leveraging lipid nanoparticles, polymers, inorganic materials, biomaterials. Finally, discuss challenges future perspectives therapy.
Language: Английский
Citations
47
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 167, P. 489 - 505
Published: June 25, 2023
Language: Английский
Citations
46
Composites Part B Engineering, Journal Year: 2022, Volume and Issue: 249, P. 110428 - 110428
Published: Nov. 17, 2022
Language: Английский
Citations
53
Nano Letters, Journal Year: 2022, Volume and Issue: 22(19), P. 7882 - 7891
Published: Sept. 28, 2022
Sepsis is a life-threatening disease caused by systemic bacterial infections, with high morbidity and mortality worldwide. As the standard treatment for sepsis, antibiotic therapy faces challenge of impaired macrophages drug-resistant bacteria. In this study, we developed membrane-camouflaged metal–organic framework (MOF) system plasmid DNA (pDNA) delivery to combat sepsis. The antimicrobial gene LL37 was efficiently encapsulated in pH-sensitive MOF, nanoparticles were decorated macrophage membranes compatible manner. Macrophage membrane coating allows targeted creates factories continuous generation peptides. Compared naked nanoparticles, primary bone marrow mesenchymal membrane-modified greatly improved survival rate immunodeficient septic mice through synergistic effect efficient inflammatory cytokine sequestration. This study demonstrates an effective biomimetic strategy delivering pDNA, offering excellent option overcoming
Language: Английский
Citations
45
Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 100, P. 106617 - 106617
Published: Sept. 23, 2023
The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.
Language: Английский
Citations
40
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(22)
Published: March 16, 2023
Abstract Sonodynamic therapy (SDT) is considered a reliable replacement to overcome the resistance antibiotics and limited tissue penetration of traditional photo‐induced therapy. Herein, ultrasmall platinum‐copper alloy nanoparticles (PtCu NPs) modified with poly (maleic anhydridealt‐1‐octadecene)‐polyethylene glycol (C 18 PMH‐PEG) high sonodynamic activity, strong catalytic ability, good glutathione (GSH) depletion performance are synthesized for highly efficient bacterial elimination. PtCu NPs obtained through thermal decomposition approach can generate toxic singlet oxygen ( 1 O 2 ) under ultrasound (US) irradiation, showing performance. Meanwhile, partial oxygenation formed on surface endows them Fenton‐like superior GSH‐depleting thus enhancing reactive species (ROS) generation. In vitro experiments confirm that PtCu‐ not only efficiently kill both gram‐positive gram‐negative bacteria but also eliminate staphylococcus aureus S. infection ROS generation then accelerate wound healing in ‐infected model. copper ions released from promote cell migration angiogenesis up‐regulation hypoxia inducible factor (HIF‐1α) platelet endothelial adhesion molecule (CD31). Finally, ‐induced deep‐seated osteomyelitis bone destruction were successfully inhibited by PtCu‐mediated combination Our work highlights novel SDT strategy enhanced elimination repair.
Language: Английский
Citations
39
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(28)
Published: April 18, 2023
Abstract Treating bacterial biofilm infections on implanted materials remains challenging in clinical practice, as bacteria can be resistant by weakening the host defense from immune cells like macrophages. Herein, a metal‐piezoelectric hetero‐nanostructure with mechanical energy‐driven antimicrobial property is situ constructed Ti implant. Under ultrasonic irradiation, formed piezotronic (piezoTi) promote generation of reactive oxygen species (ROS) facilitating local charge transfer at surface, thus leading to piezodynamic killing Staphylococcus aureus ( S. ) while downregulating biofilm‐forming genes. In addition, stimulated macrophages piezoTi display potent phagocytosis and anti‐bacterial activity through activation PI3K‐AKT MAPK pathway. As demonstration, one‐time ultrasound irradiation pillar an osteomyelitis model efficiently eliminates infection rescues implant enhanced osteointegration. By synergistic effect ultrasound‐driven therapy immuno‐regulation, proposed piezoelectric nanostructured surface endow implants highly efficient antibacterial performance antibiotic‐free, noninvasive, on‐demand manner.
Language: Английский
Citations
34