Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Language: Английский

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Review of Ti₃C₂T_x MXene Nanosheets and their Applications

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 9847 - 9867

Published: May 1, 2024

MXene Ti3C2Tx is a two-dimensional (2D) nanosheet material from the family formed by selective etching of aluminum atoms in ternary carbide Ti3AlC2 sheet. This process results 2D with titanium and fluorine on surface. has several attractive properties for various applications, such as excellent electrical conductivity mechanical good chemical stability. also large surface area can be easily functionalized introducing different groups onto its Some notable applications include supercapacitors batteries owing to high area. been explored catalyst reactions, including hydrogen evolution CO2 reduction. The main emphasis this review centered around exploring electrical, magnetic, optical characteristics MXenes. Additionally, it provides concise overview approaches used synthesizing these materials, specifically top-down bottom-up methods. Furthermore, thoroughly examines significant MXenes across multiple fields, encompassing biology, water remediation, sensors, catalysis, energy storage, membrane separation, wearable electronics. considers challenges that arise when working offers insights into potential future directions perspectives field. Overall, promising widespread application research ongoing.

Language: Английский

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A Multifunctional Bimetallic Nanoplatform for Synergic Local Hyperthermia and Chemotherapy Targeting HER2‐Positive Breast Cancer

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Anti-HER2 (human epidermal growth factor receptor 2) therapies significantly increase the overall survival of patients with HER2-positive breast cancer. Unfortunately, a large fraction may develop primary or acquired resistance. Further, multidrug combination used to prevent this in clinic places significant burden on patients. To address issue, work develops nanotherapeutic platform that incorporates bimetallic gold-silver hollow nanoshells (AuAg HNSs) exceptional near-infrared (NIR) absorption capability, small-molecule tyrosine kinase inhibitor pyrotinib (PYR), and Herceptin (HCT). This realizes targeted delivery multiple therapeutic effects, including chemo-and photothermal activities, oxidative stress, immune response. In vitro assays reveal HCT-modified nanoparticles exhibit specific recognition ability effective internalization by cells. The released PYR inhibit cell proliferation downregulating HER2 its associated pathways. NIR laser application induces effect tumor apoptosis, whereas an intracellular reactive oxygen species burst amplifies stress triggers cancer ferroptosis. Importantly, multimodal therapy also promotes upregulation genes related TNF NF-κB signaling pathways, enhancing activation immunogenic death. vivo studies confirm reduction volume after treatment, substantiating potential effectiveness these nanocarriers.

Language: Английский

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Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Biomaterials Science, Journal Year: 2022, Volume and Issue: 11(4), P. 1182 - 1214

Published: Dec. 20, 2022

A review of the recent progress ROS-upgrading nanosystems in oncotherapy is presented.

Language: Английский

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Advances of MXenes; Perspectives on Biomedical Research

Biosensors, Journal Year: 2022, Volume and Issue: 12(7), P. 454 - 454

Published: June 25, 2022

The last decade witnessed the emergence of a new family 2D transition metal carbides and nitrides named MXenes, which quickly gained momentum due to their exceptional electrical, mechanical, optical, tunable functionalities. These outstanding properties also rendered them attractive materials for biomedical biosensing applications, including drug delivery systems, antimicrobial tissue engineering, sensor probes, auxiliary agents photothermal therapy hyperthermia etc. hydrophilic nature MXenes with rich surface functional groups is advantageous applications over hydrophobic nanoparticles that may require complicated modifications. As an emerging material numerous phases endless possible combinations other materials, 1D nanoparticles, macromolecules, polymers, etc., opened vast

Language: Английский

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Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon–Electron Coupling Effect Using Two‐Dimensional Catalytic Planar Defects

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(9)

Published: Dec. 16, 2022

Conferring catalytic defects in sonosensitizers is of paramount importance reinforcing sonodynamic therapy. However, the formation such 0D governed by Schottky defect principle. Herein, 2D planar are designed within Ti3 C2 sheets to address this challenge. These specific slip dislocations with abundant Ti3+ species (Ti3 -SD(Ti3+ )) can yield surface-bound O due effective activation O2 , thus resulting a substantial amount 1 generation and 99.72% ± 0.03% bactericidal capability subject ultrasound (US) stimulation. It discovered that intervene electron transfer through phonon drag effect-a coupling effect between surface electrons US-triggered phonons-that simultaneously contributes dramatic decrease energy from 1.65 0.06 eV. This design has achieved qualitative leap which US site transformed 2D. Moreover, it revealed origin, transfer, visible pathway triggered be attributed phonon-electron effect. After coating neutrophil membrane (NM) proteins, NM-Ti3 ) further demonstrate 6-log10 reduction methicillin-resistant Staphylococcus aureus burden infected bony tissue.

Language: Английский

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MXene‐Based Functional Platforms for Tumor Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: May 5, 2023

Abstract Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly construction functional platforms for optimal antitumor therapy due to their high specific surface area, tunable performance, strong absorption near‐infrared light as well preferable plasmon resonance effect. In this review, progress MXene‐mediated is summarized after appropriate modifications or integration procedures. The enhanced treatments directly performed by MXenes, significant improving effect MXenes on different therapies, imaging‐guided strategies are discussed detail. Moreover, existing challenges future development directions presented.

Language: Английский

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Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(24), P. 24883 - 24900

Published: Oct. 26, 2023

Surgical resection is the first-line therapy for breast cancer. However, residual tumor cells and highly immunosuppressive microenvironment (TME) continue to have a serious impact on recurrence metastasis postresection. Implantation of an

Language: Английский

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