Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair

Bioactive Materials, Journal Year: 2023, Volume and Issue: 24, P. 477 - 496

Published: Jan. 9, 2023

Large bone defects resulting from fractures and disease are a major clinical challenge, being often unable to heal spontaneously by the body's repair mechanisms. Lines of evidence have shown that hypoxia-induced overproduction ROS in defect region has impact on delaying regeneration. However, replenishing excess oxygen short time cause high tension affect activity osteoblast precursor cells. Therefore, reasonably restoring hypoxic condition microenvironment is essential for facilitating repair. Herein, we designed scavenging responsive prolonged oxygen-generating hydrogels (CPP-L/GelMA) as "bone regulative hydrogel" reverse region. CPP-L/GelMA comprises an antioxidant enzyme catalase (CAT) ROS-responsive oxygen-releasing nanoparticles (PFC@PLGA/PPS) co-loaded liposome (CCP-L) GelMA hydrogels. Under condition, can release CAT degrading hydrogen peroxide generate be triggered superfluous continuously more than 2 weeks. The enriched generated hydrogel significantly enhanced angiogenesis osteogenesis while inhibited osteoclastogenesis. Finally, showed excellent regeneration effect mice skull model through Nrf2-BMAL1-autophagy pathway. Hence, CPP-L/GelMA, tissue respiration, effectively scavenge provide supply according demand region, possessing great therapeutic potential.

Language: Английский

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Probiotic‐Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(3)

Published: Nov. 7, 2022

Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane (EM) as surface biodegradable diselenide-bridged mesoporous silica nanoparticles (SeM) core. When orally administered, probiotic-inspired nanomedicine (SeM@EM) adheres strongly mucus layer restored balance regulation homeostasis a murine model acute induced dextran sodium sulfate. In addition, respective properties EM SeM synergistically alter microbiome favorable state increasing diversity shifting profile anti-inflammatory phenotype. This work suggests safe effective that can IBDs therapy.

Language: Английский

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Selective degradation of organic micropollutants by activation of peroxymonosulfate by Se@NC: Role of Se doping and nonradical pathway mechanism

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 452, P. 131202 - 131202

Published: March 15, 2023

Language: Английский

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Glycopeptide‐Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(29)

Published: April 23, 2023

Abstract Excessive inflammation, bacterial infection, and blocked angiogenesis make diabetic wound healing challenging. Multifunctional dressings have several advantages in healing. In addition, the pH regulation of microenvironment is shown to be a key factor that promotes skin regeneration through cellular immune regulation. However, few reports focused on development functional with ability regulate promote This study presents novel approach for regulating sites using glycopeptide‐based hydrogel consisting modified hyaluronic acid poly(6‐aminocaproic acid). forms network Schiff base interactions metal complexation, which suppresses inflammation accelerates during Hydrogels not only adequate mechanical properties self‐healing but can also support tissue adhesion. They secretion inducible cAMP early repressor, polarization macrophages toward M2 type. The vivo results confirm repair by exerting rapid anti‐inflammatory effects promoting angiogenesis. Therefore, this system represents an effective strategy treating wounds.

Language: Английский

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Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 354, P. 1 - 18

Published: Dec. 27, 2022

Language: Английский

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Nanozymes for nanohealthcare

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: May 30, 2024

Language: Английский

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An Orally-Administered Nanotherapeutics with Carbon Monoxide Supplying for Inflammatory Bowel Disease Therapy by Scavenging Oxidative Stress and Restoring Gut Immune Homeostasis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 21116 - 21133

Published: Oct. 16, 2023

Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant limitations due to their potential off-target systemic side-effects. Currently, there is a lack of understanding on how effectively address excessive oxidative stress, dysregulated immune homeostasis, and microbiota dysbiosis within the IBD microenvironment. Herein, we introduce nanotherapeutic approach, named LBL-CO@MPDA, treatment. LBL-CO@MPDA an orally administered formulation that supplies carbon monoxide (CO) therapeutic purposes. To create nanocomposite, developed layer by (LBL) self-assembly strategy where coated chitosan/alginate polyelectrolytes onto surface CO prodrug-loaded mesoporous polydopamine nanoparticles (CO@MPDA). Benefiting from negatively charged LBL coating, it allows targeted accumulation specifically positively inflamed colon lesions through electrostatic interactions. Furthermore, in microenvironment colon, system releases responsive manner. Interestingly, CO@MPDA ameliorates conditions MPDA-mediated ROS-scavenging CO-mediated immunomodulation. CO-supplying activates heme oxygenase-1, leading macrophage M2 polarization via Notch/Hes1/Stat3 signaling pathway, while suppressing response down-regulating p38 MAPK NF-κB (p50/p65) pathways. In mice model dextran sulfate sodium (DSS)-induced IBD, reverses pro-inflammatory restores gut barrier functions multiple mechanisms, including scavenging restoring modulating microbiota. Collectively, our findings highlight promising this innovative treatment IBD.

Language: Английский

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Efficient Therapy of Inflammatory Bowel Disease (IBD) with Highly Specific and Durable Targeted Ta₂C Modified with Chondroitin Sulfate (TACS)

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(36)

Published: May 24, 2023

Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in treatment different diseases because its excellent physicochemical properties but is far from being explored IBD. Here, Ta2 C modified with chondroitin sulfate (CS) (TACS) evaluated highly nanomedicine Specifically, TACS dual targeting CS functions due to IBD lesion-specific positive charges high expression CD44 receptors. Thanks acid stability, sensitive CT imaging function, strong reactive oxygen species (ROS) elimination ability, oral can accurately locate delineate through non-invasive imaging, specifically treat effectively levels ROS central factor progression As expected, much better therapeutic effects than clinical contrast agent first-line drug 5-aminosalicylic acid, respectively. The mechanism mainly involves protection mitochondria, oxidative stress, inhibiting macrophage M1 polarization, intestinal barrier, restoration flora balance. Collectively, this work provides unprecedented opportunities nanomedicines

Language: Английский

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An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 229 - 244

Published: Dec. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Language: Английский

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Nanogels: Synthesis, properties, and recent biomedical applications

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 139, P. 101167 - 101167

Published: July 26, 2023

Language: Английский

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